Results 211 to 220 of about 81,731 (259)

Resistance‐exercise‐induced stress intervenes in TGF‐β signaling by cooperatively downregulating nuclear αB‐crystallin and SMAD4 in human skeletal muscle fibers

The FEBS Journal, Volume 293, Issue 15, Page 4624-4644, August 2026.
Alpha‐crystallin B chain (CRYAB) has been reported to stabilize mothers against decapentaplegic homolog 4 (SMAD4) in transforming growth factor‐β (TGF‐β) signaling, enabling target gene transcription. We show nuclear CRYAB–SMAD4 interaction for the first time in human skeletal muscle fibers and its regulation by exercise.
Kirill Schaaf, Cassandra Duda, Tihomir Kostov, Patrick Diel, Käthe Bersiner, Wilhelm Bloch, Sebastian Gehlert, Daniel Jacko   +7 more
wiley   +1 more source

Antagonistic SMAD2/3 control of TIMP-1, VEGF-A, and hypoxia signaling in myofibroblasts shapes histotype-specific angiogenesis in lung cancer. [PDF]

Cell Death Dis
Díaz-Valdivia N, Duch P, Ikemori R, Parker AL, Arshakyan M, Llorente A, Bernardo A, Rodríguez-Rojas J, Carrasco JL, Park D, Sahai E, Fillat C, Juan M, Nadal E, Reguart N, Radisky DC, Casanovas O, Alcaraz J.   +17 more
europepmc   +1 more source

Mechanisms and Research Progress of Leech in Diabetic Ulcer Fibrosis

International Wound Journal, Volume 23, Issue 8, August 2026.
ABSTRACT Delayed wound healing is a major complication of diabetes, with its core pathological process being pathological fibrosis driven by persistent inflammation, metabolic disorders and vascular dysfunction under hyperglycemia. This process involves pathological retention of inflammatory cells, abnormal expression of pro‐fibrotic factors, and ...
Yanchun Wang, Xianglong Zheng, Huafa Que, Zhangren Yan   +3 more
wiley   +1 more source

Activin A-Endothelin-1 Axis Governs Pulmonary Vascular Remodeling: Mechanistic Basis for Emerging Therapies in PAH. [PDF]

Arterioscler Thromb Vasc Biol
Faizah NN, Ryanto GRT, Kencana SMS, Suzuki Y, Hara T, Otake H, Emoto N.   +6 more
europepmc   +1 more source

miR‐640 Enhances Abemaciclib Sensitivity by Suppressing CDK Inhibitor Resistance‐Associated Genes in Breast Cancer Cells

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT We investigated the potential of miR‐640 to downregulate CDK4/6 inhibitor resistance‐associated genes and evaluated its apoptotic, anti‐metastatic and anti‐proliferative effects, both alone and in combination with abemaciclib in breast cancer cells. miR‐640 was identified via GSE126125 dataset analysis.
Ismail Mert Alkac, Cigir Biray Avci
wiley   +1 more source

IGF2BP3 promotes progression of head and neck cancers through the circHECTD2/hsa_miR_4310/7157-5p/Smad2 signaling axis in an m⁶A modification-dependent manner. [PDF]

Mol Cancer
Wu K, Chang F, Peng T, Wang S, Sun X, Wang Y, Li Z, Duan C, Li J, Zhang Y, Su T, Li W, Wei D, Cao S, Liu J, Fang J, Chen L, Li G, Gross N, Zhao J, Lei D.   +20 more
europepmc   +1 more source

Mechanotransduction of Collagen Biostimulators: Comparative Signaling and Implications for GLP‐1 RA–Associated Facial Aging

Journal of Cosmetic Dermatology, Volume 25, Issue 8, August 2026.
ABSTRACT Background GLP‐1 receptor agonists (GLP‐1 RAs) can induce rapid weight reduction, often associated with facial volume loss. However, optimal regenerative strategies remain unclear. Aims To compare the mechanotransduction profiles of the major injectable collagen biostimulator classes in GLP‐1 RA–induced facial aging.
Chang‐Hwan Cho, Atsuko Yanagawa, Beomjoon Kim   +2 more
wiley   +1 more source

Efficient Inhibition of TGF-β Signaling via Cytosolic Delivery of a Smad2/3-Binding Peptide Using the Cell-Penetrating PG-Surfactant <b>DKDKC</b>_<b>12</b><b>-K</b>_<b>5</b> to Block Smad2/3 Nuclear Translocation. [PDF]

Bioconjug Chem
Suzuki R, Kono N, Kawasaki R, Inoue Y, Yamada M, Imai T, Umezawa N, Ikeda A, Tsukiji S, Mizuno T.   +9 more
europepmc   +1 more source

Dichotomous SMAD2/3 regulation and selective antihypertrophic activity of heparin during in vitro chondrogenesis of mesenchymal stromal cells. [PDF]

Cell Mol Biol Lett
Schmidt S, Chasan S, Dietmar HF, Klampfleuthner FAM, Hesse E, Walker T, Freudenberg U, Richter W, Diederichs S.   +8 more
europepmc   +1 more source

TGF-β1 induces epithelial-mesenchymal transition and fibrosis of ureteral epithelial cells via targeting RACK1 in ureteropelvic junction obstruction. [PDF]

Transl Pediatr
Chen W, Ye F, Lin X, Chen J, Yang F, Wang Y, Lin S, Huang W, Jian Z, Zhou C.   +9 more
europepmc   +1 more source