Results 121 to 130 of about 40,465 (206)

MMP9 regulates osteogenesis and MMP2 expression through the TGF-β1/SMAD2/3 signaling pathway in lipopolysaccharide-induced osteoblasts. [PDF]

Braz J Med Biol Res
Li L, Yang Y, Lu X, Li H.
europepmc   +1 more source

A Non‐Canonical Role of SMAD4 in Regulating 3D Genome Architecture to Inhibit Lung Squamous Cell Carcinoma Development

Advanced Science, Volume 13, Issue 47, 24 August 2026.
SMAD4 is identified as a guardian of 3D genome architecture in lung squamous cell carcinoma. Loss of SMAD4 unleashes EP300 at chromatin loop anchors, strengthening enhancer–promoter looping and H3K27ac at the SOX2 locus to drive aberrant SOX2 activation and tumor cell proliferation.
Qian Tang, Chen Lian, Xinyan Han, Xuhan Zhang, Zihan Wang, Boyu Wang, Taoyu Zhu, Xinrui Lin, Xiaolei Wang, Yaping Xu, Manyu Xiao, Zijin Wang, Junming Li, Silin Chen, Yunze Wang, Yufei Liu, Songsong Li, Zuolin Shen, Xi Lu, Xueqi Han, Yilu Zhou, Mingyang Xiao, Jiayi Ran, Xiaoran Cao, Xinyi Xu, Hugo Sámano‐Sánchez, Alfredo Rodríguez, Lian Wang, Shuifang Chen, Zhanyu Xu, Shirong Zhang, Nuo Yang, Yong Tang, Jian Liu   +33 more
wiley   +1 more source

Bone Marrow-Derived Macrophage NLRP3 Mediates Renal Fibrosis by triggering TGF-β/Smad3-mediated Macrophage-Myofibroblast Transition. [PDF]

Int J Biol Sci
Wang W, Li J, Zhong Y, Chen J, Wu L, Wan L, Huang XR, Ye Z, Yu X, Lan HY.   +9 more
europepmc   +1 more source

The Dynamic Alliance of p53 and Metabolism in the Tumor Microenvironment Shapes Tumor Evolution

BioEssays, Volume 48, Issue 8, August 2026.
p53 is an adaptive processor positioned at the interface between metabolism and the tumor microenvironment. By integrating nutrient, mechanical, inflammatory, and redox cues while reciprocally remodeling metabolism, stromal and immune compartments, and cancer cell plasticity, WT and mutant p53 orchestrate cell competition, tumor evolution, metastasis ...
Sebastien M. Joruiz, Francesco Napoletano, Rebecca Bertolio, Giannino Del Sal   +3 more
wiley   +1 more source

Antibody-conjugated SIS3-loaded PLGA@polydopamine nanoparticles alleviate cardiac fibrosis by modulating Smad3 signaling in myofibroblasts. [PDF]

J Nanobiotechnology
Chen C, Lu W, Pan Q, Cui C, Zhang Y, Wang H, Han J, Yuan S, Lin Z, Xie Y, Dou K, Hou J.   +11 more
europepmc   +1 more source

MicroRNAs in Spinal Cord Injury: Molecular and Translational Insights

Brain and Behavior, Volume 16, Issue 8, August 2026.
MicroRNAs (miRNAs) modulate secondary injury cascades following spinal cord injury (SCI), including inflammation, oxidative stress, apoptosis, and demyelination. Key miRNAs such as miR‐21, miR‐124, miR‐219, and miR‐223 exert neuroprotective effects by regulating astrocytic response, axon regeneration, and remyelination.
Seyyedeh Fahimeh Talebi, Hossein Kalarestaghi, Ehsan Sheikh Hesabi, Saeed Vafaei‐Nezhad   +3 more
wiley   +1 more source

Lumican-TLR4 interaction accelerates hepatic fibrosis by activating hepatic stellate cells. [PDF]

Hepatol Commun
Xiong Y, Zhang H, Wang A, Cui Y, Ye J, Jin L, Lin M, Zhang Q, Liang G, Luo W, Zhu W, Hu X.   +11 more
europepmc   +1 more source

From scarring to healing: Emerging regenerative therapies for pulmonary fibrosis using MSCs and exosomes

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
MSCs exert anti‐inflammatory, anti‐fibrotic and regenerative effects in pulmonary fibrosis. MSC‐derived exosomes reproduce many therapeutic benefits of parental MSCs. Preconditioning and genetic modification improve MSC therapeutic performance. Current preclinical and clinical evidence supports the translational potential of MSC‐based therapies ...
Hajar Nasiri, Farbod Khosravi, Fatemeh Eskandari, Tahereh Manoochehrabadi, Ali Samadikuchaksaraei, Ehsan Lotfi, Jila Majidi, Fatemeh Rafati, Zeynab Ghorbani   +8 more
wiley   +1 more source

Integrated Genomic and Single-Cell Analysis Identifies Notch1 as a Metastasis Suppressor in Nasopharyngeal Carcinoma Targeted by the AKT/Smad3 Axis. [PDF]

Biol Proced Online
Zuo J, Huang S, Dai M, Li F, Huang T, Wang L, Qi C, Tao Z, Ye L.   +8 more
europepmc   +1 more source

Effects of Naringenin on Diabetic Nephropathy: A Systematic Review and Meta‐Analysis of Rodent Studies

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Naringenin produces comprehensive renoprotective effects in rodent models of diabetic nephropathy. It mainly lowers blood sugar and alleviates renal dysfunction by reducing proteinuria, serum creatinine, and blood urea nitrogen. Meanwhile, naringenin improves antioxidant status by elevating glutathione and reducing malondialdehyde, and suppresses ...
Yuzhu Qu, Jie Chen, Ling Yue, Xinyue Zhang, Kongmei Ou, Yiting Wang, Runjia He, Benxiang He   +7 more
wiley   +1 more source