Results 131 to 140 of about 40,465 (206)

Paraxanthine and azilsartan attenuate gentamicin-induced renal fibrosis via modulation of TGF-β1/Smad3/7 signaling and miRNA-21/miRNA-200b expression. [PDF]

J Transl Med
Rizk El-Adwy NS, El-Ashmawy NE, Al-Ashmawy GM, Khedr NF.   +3 more
europepmc   +1 more source

Sex‐Specific Anti‐Inflammatory Effects of Alternate Day Fasting via TLR4 and Leptin Signaling in Middle‐Aged Rats

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
ADF downregulates TLR4, reducing hypothalamic and hepatic inflammation, with stronger effects in females. ADF enhances leptin sensitivity in aging by reducing SOCS3 and upregulating ObRb, thereby improving metabolic function. ADF reduces retroperitoneal fat and glucose levels, with females experiencing greater fat loss.
Ozgen Kilic‐Erkek, Gulsah Gundogdu, Abdullah Coguplugil, Yavuz Dodurga   +3 more
wiley   +1 more source

BMAL1 regulates tubular epithelial-derived exosomal miR-27a-3p to inhibit macrophage-myofibroblast transition and alleviate ischemia/reperfusion-induced renal fibrosis. [PDF]

Theranostics
Chen W, Zhao S, Yang S, Yu W, Rao T, Zhou X, Ruan Y, Zou F, Cheng F, Li W.   +9 more
europepmc   +1 more source

4‐FPAC‐Modulated Tumor‐Associated Macrophage Conditioned Media Suppresses Malignant Phenotypes and Promotes Cell‐Cycle Arrest and Apoptosis in NSCLC

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
4‐FPAC‐modulated TAM conditioned media attenuated proliferation, EMT, angiogenesis, and stemness while inducing cell‐cycle arrest and apoptosis in NSCLC cells. These anti‐tumor effects were associated with disruption of the IL8–CD163 axis, supporting the potential of 4‐FPAC as a tumor microenvironment‐targeted therapeutic agent. ABSTRACT Non‐small cell
Anjali Singh, Dhanush Danes, Suresh Balakrishnan   +2 more
wiley   +1 more source

Ischemic stroke as an initial manifestation of Loeys-Dietz syndrome type 3 caused by the recurrent p.Arg287Trp variant in <i>SMAD3</i>: a case report with familial context. [PDF]

Front Genet
Chen CX, Zhou YY, Hong ZQ, Hong QL.
europepmc   +1 more source

The Impact of Ageing on Skeletal Muscle: Roles of Mitochondrial Dysregulation, Systemic Communication, and Exercise

Journal of Cellular Physiology, Volume 241, Issue 8, August 2026.
ABSTRACT Ageing is a major risk factor for degenerative diseases, including sarcopenia, which is characterized by a progressive loss of skeletal muscle mass and function, frailty, and is associated with increased mortality. Skeletal muscle regeneration relies on muscle stem cells and efficient communication with cellular microenvironment.
Juan Diego Hernández‐Camacho, Marielle Saclier   +1 more
wiley   +1 more source

Palmitoylation Induced Activation of SMAD3 Exacerbates Colitis by Promoting Tissue-resident Memory T Cells Differentiation. [PDF]

Inflammation
Xu Y, Ji S, Jiang P, Zhao Z, Zhou Q, Su D, Ullah S, Zhao Y, Zou X, Zhang M, Sun J, Xu G, Tang J.   +12 more
europepmc   +1 more source

Tumor Plasticity and Microenvironmental Crosstalk as Drivers of Metastasis and Therapy Resistance

MedComm, Volume 7, Issue 8, August 2026.
The graphical abstract is a schematic illustration of the bidirectional crosstalk between tumor plasticity and the tumor microenvironment (TME) in driving metastasis and therapy resistance. Tumor‐intrinsic factors such as genetic mutations and epigenetic reprogramming enable dynamic transitions between epithelial, mesenchymal, and cancer stem cell ...
Gunjan Dagar, Manisha Dagar, Ashna Gupta, Anju Surendranath, Suraja Kumar Das, Mohd Umar Rehmani, Mukesh Tanwar, Sameer Mirza, Muzafar A. Macha, Ammira S. Al‐Shabeeb Akil, Shahab Uddin, Mayank Singh, Ajaz A. Bhat   +12 more
wiley   +1 more source

VHL-recruiting PROTAC attenuates AKI-CKD transition via simultaneous degradation of Smad3 and stabilization of HIF-2α. [PDF]

Cell Death Dis
Ruan Y, Wang D, Xu Y, Yang J, Chen Y, Fan J, Tang SCW, Chen W, Wang X.   +8 more
europepmc   +1 more source

SIRT Family: Biological Functions and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang, Feng‐Li Jiang, Fang‐Yuan Zhang, Dong‐Hui Huang, Xiao‐Ying Li, Song Gao, Hua You, Qi‐Jun Wu, Huan‐Huan Chen, Ting‐Ting Gong   +9 more
wiley   +1 more source