Results 151 to 160 of about 40,465 (206)

A Novel Anti-Fibrotic Role of G-Protein-Coupled Receptor 119 in Hepatic Stellate Cells. [PDF]

Biomol Ther (Seoul)
Park J, Lee MH, Kim HY, Kim HS, Kim SK, Yang JW, Kang KW.   +6 more
europepmc   +1 more source

Conjunctival Sac‐Derived Lactobacillus mucosae MM‐1 Metabolite Indole‐3‐Lactic Acid Attenuates Lens‐Induced Myopia in Mice via AHR Activation and TGF‐β/Smad Inhibition

Microbial Biotechnology, Volume 19, Issue 8, August 2026.
This study proposes a ‘conjunctival sac microecology‐metabolite‐scleral remodelling’ regulatory axis, highlighting the potential role of conjunctival sac microbiota in maintaining ocular surface health and regulating lens‐induced myopia in mice, providing an important theoretical foundation for the development of microbiome‐based interventions for ...
Yanqing Li, Qiuyu Wu, Xilong Zhang, Luchuan Liu, Leiping Ding, Jingjing Xu, Chiwen Cheng, Yangyang Peng, Kang Yu, Wen Yao, Yijie Pi, Jiale Li, Di Wu, Jing Wei, Yifeng Yu, Tingtao Chen   +15 more
wiley   +1 more source

E3 ligase SMURF2 promotes adipogenesis and improves obesity complications by suppressing TGF-β signaling. [PDF]

J Lipid Res
Wu X, Wu M, Du S, Liu J, Wang R, Sun Y, Zheng Z, Yang J, Jia X, Wang L, Lu T, Yang C, Gao Y, Fang D.   +13 more
europepmc   +1 more source

Down‐Regulation of TFEB With Defective Autophagy in the Susceptibility of Aging Kidneys to Septic Acute Kidney Injury

Aging Cell, Volume 25, Issue 8, August 2026.
Aging is associated with impaired TFEB‐dependent autophagy in renal proximal tubular epithelial cells, leading to increased susceptibility to LPS‐induced injury and inflammation. Restoration of autophagy through TFEB activation or Tat–Beclin 1 treatment partially rescues autophagic function and confers protection against elderly sepsis‐associated acute
Yu Xiang, Ying Fu, Zhiwen Liu, Yu Han, Wenwen Wu, Juan Cai, Dongshan Zhang, Zheng Dong   +7 more
wiley   +1 more source

Macrophage NEDD4L restrains liver fibrosis by preventing scar-associated macrophage expansion via ubiquitination of phospho-SMAD3. [PDF]

Int J Biol Sci
He Y, Ge S, Ling S, Yang S, Yang F, Liu X, Dong S, Chen Y, Zhang Z, Zhou Y, Hwang S, Kim SJ, Wang P, He Y, Chen Y.   +14 more
europepmc   +1 more source

Application of Systems Genetics to Investigate Molecular Pathology of Early‐Onset Colorectal Cancer

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
Early‐onset colorectal cancer (EOCRC) presents a complex molecular landscape that requires integrated multi‐omics approaches. This article reviews current applications of systems genetics in EOCRC research and provides a step‐by‐step protocol for network‐based analyses featuring PIK3CA to demonstrate practical application for researchers of all levels.
Minjae J. Kim, Sydney L. Carr, Vishnutheertha Kulkarni, Mary‐Louise Manchadi   +3 more
wiley   +1 more source

Combining bioinformatics and machine learning to analyze and validate sepsis-related cell senescence genes and potential drugs. [PDF]

Ren Fail
Pei S, Li D, Yu X, Huang X, Liu J, Song Y, Zhu L, Cui J, Cui Y, Xie K.   +9 more
europepmc   +1 more source

Hepatocyte TrkB Acts as a Gatekeeper Against MASH‐Related Liver Fibrosis by Suppressing the TGFβ/CCL2 Axis and Macrophage Infiltration

Cell Proliferation, Volume 59, Issue 8, August 2026.
Hepatocyte TrkB is identified as a critical gatekeeper against MASH‐related fibrosis. Mechanistically, TrkB inhibits the TGFβ/SMAD3/FOS axis to suppress CCL2 secretion, thereby blocking pathogenic macrophage recruitment and ameliorating liver fibrosis.
Yueying Chen, Jiayi Wei, Shuxuan Li, Kefan Yin, Heming Wang, Yicheng Zhao, Shuqiang Weng, Xizhong Shen, Guangqi Song, Changfeng Zhu, Qunyan Yao, Ling Dong   +11 more
wiley   +1 more source

Ectopic CD11c Drives SMAD3-Mediated Aberrant Antigen Presentation and Epithelial-Mesenchymal Transition in Esophageal Squamous Cell Carcinoma. [PDF]

Cancer Commun (Lond)
Liao H, Zhao X, Chen L, Liu Q, Li C, Li K, Xi Y, Shen Y, Tan W, Wu C, Lin D.   +10 more
europepmc   +1 more source

Lysine l‐Lactylation: Bridging Metabolism, Chromatin and Disease

Cell Proliferation, Volume 59, Issue 8, August 2026.
Enzymatic regulation of KL‐la. The enzymatic regulation of KL‐la involves two distinct pathways for L‐lactate accumulation: intracellular production through glycolysis‐derived pyruvate conversion by lactate dehydrogenase (LDH) or direct cellular uptake via monocarboxylate transporters (MCTs). These L‐lactate pools fuel two distinct lactylation pathways—
Anoosha Malik, Muhammad Dilawar, Junguang Liao, Jie Zheng, Qitao Qian, Ming Xu, Sisi Lin, Xiaobo Zhu, Qiuwei Ge, Limin Jin, Guiqian Chen   +10 more
wiley   +1 more source