Results 161 to 170 of about 40,465 (206)

Super-Enhancer-Driven SOX4/SMAD3 Mediate Membrane Remodeling by Regulating Phospholipid Metabolism to Accelerate Leukemia Progression. [PDF]

Adv Sci (Weinh)
Lou E, Lai P, Peng G, Lu B, Jiang L, Li X, Chen J, Mo L, Mao Q, Zhang H, Fang J, Meng Y, Liu A, Gao Y, Huang A, Lin W, Hu S, Guan Z, Ye X, Liu Z, Jiang L, Zheng Y, Shi X.   +22 more
europepmc   +1 more source

Resistance‐exercise‐induced stress intervenes in TGF‐β signaling by cooperatively downregulating nuclear αB‐crystallin and SMAD4 in human skeletal muscle fibers

The FEBS Journal, Volume 293, Issue 15, Page 4624-4644, August 2026.
Alpha‐crystallin B chain (CRYAB) has been reported to stabilize mothers against decapentaplegic homolog 4 (SMAD4) in transforming growth factor‐β (TGF‐β) signaling, enabling target gene transcription. We show nuclear CRYAB–SMAD4 interaction for the first time in human skeletal muscle fibers and its regulation by exercise.
Kirill Schaaf, Cassandra Duda, Tihomir Kostov, Patrick Diel, Käthe Bersiner, Wilhelm Bloch, Sebastian Gehlert, Daniel Jacko   +7 more
wiley   +1 more source

Erratum: [Corrigendum] Inhibition of microRNA-221-5p induces osteogenic differentiation by directly targeting smad3 in myeloma bone disease mesenchymal stem cells. [PDF]

Oncol Lett
Fan FY, Deng R, Lai SH, Wen Q, Zeng Y, Gao L, Liu Y, Kong P, Zhong J, Su Y, Zhang X.   +10 more
europepmc   +1 more source

Mechanisms and Research Progress of Leech in Diabetic Ulcer Fibrosis

International Wound Journal, Volume 23, Issue 8, August 2026.
ABSTRACT Delayed wound healing is a major complication of diabetes, with its core pathological process being pathological fibrosis driven by persistent inflammation, metabolic disorders and vascular dysfunction under hyperglycemia. This process involves pathological retention of inflammatory cells, abnormal expression of pro‐fibrotic factors, and ...
Yanchun Wang, Xianglong Zheng, Huafa Que, Zhangren Yan   +3 more
wiley   +1 more source

GA-binding protein alpha ensures proper blastocyst development by suppressing SMAD3-mediated transforming growth factor-beta signaling. [PDF]

Protein Cell
Liao J, Ma Y, Liu Y, Guo R, Yao H.
europepmc   +1 more source

Exosome‐Mediated Delivery of PROTACs for Targeted Protein Degradation in Cancer, Neurodegenerative, Infectious, and Inflammatory Diseases

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are heterobifunctional molecules that hijack the ubiquitin‐proteasome system to drive catalytic, sub‐stoichiometric degradation of disease‐associated proteins, offering a mechanistic advantage over occupancy‐driven inhibitors and access to ‘undruggable’ targets.
Sruti Bagchi Ghosh, Rumpa Banerjee, Hailah M. Almohaimeed, Amany I. Almars, Tahani Ahmad ALMatrafi, Fayez M. Saleh, Zuhair M. Mohammedsaleh, Kranti Kiran Reddy Ealla, Ajoy Kumer, Bikram Dhara   +9 more
wiley   +1 more source

SMYD3 synergises with RACK1 to promote colorectal cancer lung metastasis by recruiting SMAD3. [PDF]

Cell Commun Signal
Bai X, Han D, Chen J, Sheng S, Feng H, Wang H, Xu K, Huang Y, Huang M, Chu X, Chen Y, Lei Z.   +11 more
europepmc   +1 more source

miR‐640 Enhances Abemaciclib Sensitivity by Suppressing CDK Inhibitor Resistance‐Associated Genes in Breast Cancer Cells

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT We investigated the potential of miR‐640 to downregulate CDK4/6 inhibitor resistance‐associated genes and evaluated its apoptotic, anti‐metastatic and anti‐proliferative effects, both alone and in combination with abemaciclib in breast cancer cells. miR‐640 was identified via GSE126125 dataset analysis.
Ismail Mert Alkac, Cigir Biray Avci
wiley   +1 more source

Nur77 Regulates the Phosphorylation of Smad3, Thereby Influencing Skeletal Muscle Fibrosis Caused by Obesity. [PDF]

FASEB J
Li N, Tian T, Zhao Q, Wang D.
europepmc   +1 more source

Impact of Oral Herbal Supplementation on Human Skin Aging: A Systematic Review of Clinical Trials

Journal of Cosmetic Dermatology, Volume 25, Issue 8, August 2026.
ABSTRACT Background Skin aging, characterized by wrinkles, decreased elasticity, and dryness, is both a public health and esthetic issue, affecting most adults and leading to lowered quality of life and higher healthcare costs. While topical treatments are common, systemic approaches are gaining interest for their potential to enhance skin hydration ...
Gisela Meydilin Sanjaya, Brilian Veda Kartika Putri, Hany Anneke, Nayla Majeda Alfarafisa, Astrid Feinisa Khairani, Nur Atik   +5 more
wiley   +1 more source