Results 1 to 10 of about 118,693 (302)
Conformational landscape of multidomain SMAD proteins [PDF]
Computational and Structural Biotechnology Journal, 2021 SMAD transcription factors, the main effectors of the TGFβ (transforming growth factor β) network, have a mixed architecture of globular domains and flexible linkers.
Tiago Gomes +5 more
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SMAD Proteins in TGF-β Signalling Pathway in Cancer: Regulatory Mechanisms and Clinical Applications [PDF]
Diagnostics, 2023 Suppressor of mother against decapentaplegic (SMAD) family proteins are central to one of the most versatile cytokine signalling pathways in metazoan biology, the transforming growth factor-β (TGF-β) pathway.
Qi Wang +8 more
doaj +2 more sources
The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion [PDF]
Cell Communication and Signaling, 2023 Background Long non-coding RNAs (lncRNAs) regulate cellular processes by interacting with RNAs or proteins. Transforming growth factor β (TGFβ) signaling via Smad proteins regulates gene networks that control diverse biological processes, including ...
Caroline Gélabert +7 more
doaj +2 more sources
SMAD proteins: Mediators of diverse outcomes during infection
European Journal of Cell Biology, 2022 Understanding the relationship between host and pathogen is key to combatting disease. SMAD transcription factors, which transmit TGF-β superfamily signalling, mediate an array of outcomes during embryogenesis, inflammation, cancer, and immunity ...
Lachlan Yuek Shun Lai +4 more
doaj +3 more sources
miRNAs in Signal Transduction of SMAD Proteins in Breast Cancer. [PDF]
Int J Mol SciThe aim of this study was to identify miRNAs that could potentially influence the activity of SMAD proteins involved in TGFβ signal transduction in five types of breast cancer in Polish women. Patients with five breast cancer subtypes were included in the study: luminal A (n = 130), luminal B HER2− (n = 100), luminal B HER2+ (n = 96), non-luminal HER2+
Sirek T +14 more
europepmc +3 more sources
Deep learning for de-convolution of Smad2 versus Smad3 binding sites
BMC Genomics, 2022 Background The transforming growth factor beta-1 (TGF β-1) cytokine exerts both pro-tumor and anti-tumor effects in carcinogenesis. An increasing body of literature suggests that TGF β-1 signaling outcome is partially dependent on the regulatory targets ...
Jeremy W.K. Ng +3 more
doaj +1 more source
The Smad Dependent TGF-β and BMP Signaling Pathway in Bone Remodeling and Therapies
Frontiers in Molecular Biosciences, 2021 Bone remodeling is a continuous process that maintains the homeostasis of the skeletal system, and it depends on the homeostasis between bone-forming osteoblasts and bone-absorbing osteoclasts.
Ming-Li Zou +17 more
doaj +1 more source
Smad Proteins Physically Interact with Calmodulin [PDF]
Journal of Biological Chemistry, 1998 The Smad family of intracellular proteins mediates signals generated by activin and other transforming growth factor beta-related proteins via specific heteromeric complexes of transmembrane receptor serine kinases (1, 2). xSmad2 has been implicated as an activin signal mediator that may participate in transcriptional regulation (3, 4).
C M, Zimmerman +2 more
openaire +2 more sources
Non-coding RNA Research, 2021 One of the complex themes in recent years has been the multi-layered regulation of TGFβ signaling in cancer cells. TGFβ/SMAD signaling pathway is a highly complicated web of proteins which work spatio-temporally to regulate multiple steps of ...
Aima Adylova +4 more
doaj +1 more source
CHIP Mediates Degradation of Smad Proteins and Potentially Regulates Smad-Induced Transcription [PDF]
Molecular and Cellular Biology, 2004 Transforming growth factor beta (TGF-beta)/bone morphogenetic protein (BMP) family ligands interact with specific membrane receptor complexes that have serine/threonine kinase activities. The receptor phosphorylation and activation induced by the ligands leads to phosphorylation of the Smad proteins, which translocate to the nucleus, controlling gene ...
Linyu, Li +8 more
openaire +2 more sources