Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses [PDF]
, 2020 The signalling pathways initiated by members of the transforming growth factor-β (TGFβ) family of cytokines control many metazoan cellular processes, including proliferation and differentiation, epithelial-mesenchymal transition (EMT) and apoptosis. TGFβ
A Rojas-Fernandez +63 more
core +2 more sources
Conformational landscape of full-length Smad proteins [PDF]
, 2021 AbstractSmad transcription factors, the main effectors of the TGFβ (transforming growth factor β) network, have been shaped along the evolution of multicellular animals to regulate essential processes. Smad proteins have a mixed architecture of globular domains and flexible linkers and adopt distinct quaternary structures depending on their activation ...
Tiago Gomes +5 more
openaire +1 more source
ZC4H2 stabilizes Smads to enhance BMP signalling, which is involved in neural development in Xenopus [PDF]
Open Biology, 2017 Bone morphogenetic proteins (BMPs) play vital roles in regulating stem cell maintenance, differentiation and embryonic development. Intracellularly, BMP signalling is mediated by Smad proteins, which are regulated post-transcriptionally through ...
Pengcheng Ma +7 more
doaj +1 more source
TGF-β/Smad Signaling Pathway in Tubulointerstitial Fibrosis
Frontiers in Pharmacology, 2022 Chronic kidney disease (CKD) was a major public health problem worldwide. Renal fibrosis, especially tubulointerstitial fibrosis, is final manifestation of CKD.
Xiao-Yong Yu +4 more
doaj +1 more source
Pin1 Protein Regulates Smad Protein Signaling and Pulmonary Fibrosis [PDF]
Journal of Biological Chemistry, 2012 Interstitial pulmonary fibrosis is caused by the excess production of extracellular matrix (ECM) by Fb in response to TGF-β1. Here, we show that the peptidyl-prolyl isomerase Pin1 modulates the production of many pro- and antifibrogenic cytokines and ECM.
Zhong-Jian, Shen +10 more
openaire +2 more sources
Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling [PDF]
, 2014 Bone morphogenetic proteins (BMPs) control multiple cellular processes in embryos and adult tissues. BMPs signal through the activation of type I BMP receptor kinases, which then phosphorylate SMADs 1/5/8.
Campbell, David +7 more
core +3 more sources
Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination
Cells, 2014 TGF-β(transforming growth factor-β) superfamily signaling mediators are important regulators of diverse physiological and pathological events. TGF-β signals are transduced by transmembrane type I and type II serine/threonine kinase receptors and their ...
Feng Xie +4 more
doaj +1 more source
HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes [PDF]
, 2010 Histone deacetylases (HDACs) regulate the acetylation of histones in the control of gene expression. Many non-histone proteins are also targeted for acetylation, including TGF-ß signalling pathway components such as Smad2, Smad3 and Smad7. Our studies in
Andrew D. Rowan +54 more
core +1 more source
Resveratrol treatment ameliorates hepatic damage via the TGF-β/SMAD signaling pathway in a phenobarbital/CCl4-induced hepatic fibrosis model [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Liver fibrosis is a wound healing response characterized by excessive accumulation of extracellular matrix proteins. This study aimed to investigate the effects of resveratrol treatment on the TGF-β/SMAD signaling pathway and related ...
Merve Aykaç +3 more
doaj +1 more source
GABARAPL1 Inhibits EMT Signaling through SMAD-Tageted Negative Feedback
Biology, 2021 The pathway of selective autophagy, leading to a targeted elimination of specific intracellular components, is mediated by the ATG8 proteins, and has been previously suggested to be involved in the regulation of the Epithelial–mesenchymal transition (EMT)
Marine Jacquet +13 more
doaj +1 more source