Results 231 to 240 of about 625,167 (353)

Mechanistic intracellular PK/PD modeling to inform development strategies for small interfering RNA therapeutics. [PDF]

Mol Ther Nucleic Acids
Chen L, Bosmajian C, Woo S.
europepmc   +1 more source

Conventional Vasopressor and Vasopressor-Sparing Strategies to Counteract the Blood Pressure-Lowering Effect of Small Interfering RNA Targeting Angiotensinogen. [PDF]

J Am Heart Assoc, 2022
Uijl E, Ye D, Ren L, Mirabito Colafella KM, van Veghel R, Garrelds IM, Lu HS, Daugherty A, Hoorn EJ, Nioi P, Foster D, Danser AHJ.   +11 more
europepmc   +1 more source

Prophylactic and Therapeutic Effects of Small Interfering Rna Targeting Sars-Coronavirus [PDF]

, 2004
Bo‐Jian Zheng, Yi Guan, Qingquan Tang, Du Cheng, Frank Xie, Ming‐Liang He, Kwok-Wah Chan, Kin‐Ling Wong, Eric Lader, Martin C. Woodle, Patrick Lu, Baojian Li, Nanshan Zhong   +12 more
openalex   +1 more source

Developing Quorum Sensing‐Based Collaborative Dynamic Control System in Halomonas TD01

Advanced Science, EarlyView.
A standardized and streamlined inducer‐free quorum sensing (QS)‐based collaborative dynamic control pattern is developed for sufficient gene expression control in Halomonas TD by mixing two engineered cells, cells A and B. Proof‐of‐concept studies are designed to test the dynamic control performance in mixed cultures in fed‐batch conditions.
Yi‐Na Lin, Yu‐Xi Li, Ye Zheng, Yi‐Hao Deng, Kai‐Xuan Liu, Yue Gan, Hao Li, Jun Wang, Jia‐Wen Peng, Rui‐Zhe Deng, Huai‐Ming Wang, Hui Wang, Jian‐Wen Ye   +12 more
wiley   +1 more source

The N-Acetylgalactosamine-conjugated small interfering RNA inclisiran can be coadministered safely with atorvastatin in cynomolgus monkeys resulting in additive low-density lipoprotein cholesterol reductions. [PDF]

Pharmacol Res Perspect, 2023
Lehoux D, Kallend D, Wijngaard PLJ, Brown AP, Zerler B.   +4 more
europepmc   +1 more source

GRP78 Nanobody‐Directed Immunotoxin Activates Innate Immunity Through STING Pathway to Synergize Tumor Immunotherapy

Advanced Science, EarlyView.
A GRP78 nanobody‐directed immunotoxin suppresses cancer progression and metastasis by enhancing antitumor immunity via STING pathway activation, offering a pan‐cancer‐targeted approach and immunotherapy combination strategy. Abstract The lack of targetable antigens poses a significant challenge in developing effective cancer‐targeted therapies.
Huifang Wang, Runhua Zhou, Chengchao Xu, Lingyun Dai, Rui Hou, Liuhai Zheng, Chunjin Fu, Guangwei Shi, Jingwei Wang, Yang Li, Jinpeng Cen, Xiaolong Xu, Le Yu, Yilei Li, Jigang Wang, Qingfeng Du, Zhijie Li   +16 more
wiley   +1 more source

Small Interfering RNA Knockdown of Calcium-independent Phospholipases A2 β or γ Inhibits the Hormone-induced Differentiation of 3T3-L1 Preadipocytes [PDF]

, 2004
Xiong Su, David J. Mancuso, Perry E. Bickel, Christopher M. Jenkins, Richard W. Gross   +4 more
openalex   +1 more source

Ultralow‐Dimensionality Reduction for Identifying Critical Transitions by Spatial‐Temporal PCA

Advanced Science, EarlyView.
The proposed spatial‐temporal principal component analysis (stPCA) method analytically reduces high‐dimensional time‐series data to a single latent variable by transforming spatial information into temporal dynamics. By preserving the temporal properties of the original data, stPCA effectively identifies critical transitions and tipping points.
Pei Chen, Yaofang Suo, Kazuyuki Aihara, Ye Li, Dan Wu, Rui Liu, Luonan Chen   +6 more
wiley   +1 more source

Counteracting Angiotensinogen Small-Interfering RNA-Mediated Antihypertensive Effects With REVERSIR. [PDF]

Hypertension
Ye D, Cruz-López EO, Veghel RV, Garrelds IM, Kasper A, Wassarman K, Tu HC, Zlatev I, Danser AHJ.   +8 more
europepmc   +1 more source

Stable expression of small interfering RNA sensitizes TEL-PDGFβR to inhibition with imatinib or rapamycin [PDF]

, 2004
Jing Chen, Nathan R. Wall, Kerry Kocher, Nicole Duclos, Doriano Fabbro, Donna Neuberg, James D. Griffin, Yang Shi, D. Gary Gilliland   +8 more
openalex   +1 more source