Small interfering RNAs in the management of human osteoporosis
British Medical Bulletin, 2023 Abstract Background Osteoporosis results in reduced bone mass and consequent bone fragility. Small interfering RNAs (siRNAs) can be used for therapeutic purposes, as molecular targets or as useful markers to test new therapies. Sources of data
Giuseppe Gargano +4 more
openaire +3 more sources
Carbon Dots for Efficient Small Interfering RNA Delivery and Gene Silencing in Plants[OPEN]
Plant Physiology, 2020 The development of a formulation for siRNA delivery enables post-transcriptional gene silencing in plants with a simple spray application. The initiation of RNA interference (RNAi) by topically applied small interfering RNA has potential applications for
Steven H. Schwartz +4 more
semanticscholar +1 more source
Endogenous small interfering RNAs in animals [PDF]
Nature Reviews Molecular Cell Biology, 2008 Until recently, only nematodes among animals had a well-defined endogenous small interfering RNA (endo-siRNA) pathway. This has changed dramatically with the recent discovery of diverse intramolecular and intermolecular substrates that generate endo-siRNAs in Drosophila melanogaster and mice.
Eric C. Lai, Katsutomo Okamura
openaire +3 more sources
Medicinal Chemistry of Oligonucleotide Drugs - Milestones of the Past and Visions for the Future
CHIMIA, 2022 The oligonucleotide therapeutics field has blossomed in recent years, with thirteen approved drugs today and the promise of accelerated growth in coming years.
Jonathan Hall +7 more
doaj +1 more source
An influenza virus-inspired polymer system for the timed release of siRNA [PDF]
, 2013 Small interfering RNA silences specific genes by interfering with mRNA translation, and acts to modulate or inhibit specific biological pathways; a therapy that holds great promise in the cure of many diseases. However, the naked small interfering RNA is
A Fire +37 more
core +2 more sources
Recent studies on non-coding small RNAs in plants
浙江大学学报. 农业与生命科学版, 2014 There are many non-coding small RNAs in plants and animals, which regulate gene expression via direct cleavage of target mRNAs or via inhibition of translation at the post-transcriptional level.
Shen Enhui +3 more
doaj +1 more source
Traffic into silence: endomembranes and post-transcriptional RNA silencing. [PDF]
, 2014 microRNAs (miRNAs) and small interfering RNAs (siRNAs) are small RNAs that repress gene expression at the post-transcriptional level in plants and animals. Small RNAs guide Argonaute-containing RNA-induced silencing complexes to target RNAs in a sequence-
Chen, Xuemei +2 more
core +3 more sources
Small interfering RNA against BCR-ABL transcripts sensitize mutated T315I cells to nilotinib
Haematologica, 2010 Background Selective inhibition of the BCR-ABL tyrosine kinase by RNA interference has been demonstrated in leukemic cells. We, therefore, evaluated specific BCR-ABL small interfering RNA silencing in BCR-ABL-positive cell lines, including those ...
Michael Koldehoff +3 more
doaj +1 more source
A small RNA response at DNA ends in Drosophila [PDF]
, 2012 Small RNAs have been implicated in numerous cellular processes, including effects on chromatin structure and the repression of transposons. We describe the generation of a small RNA response at DNA ends in Drosophila that is analogous to the recently ...
Böttcher, Romy +2 more
core +1 more source
Global analyses of endonucleolytic cleavage in mammals reveal expanded repertoires of cleavage-inducing small RNAs and their targets. [PDF]
, 2016 In mammals, small RNAs are important players in post-transcriptional gene regulation. While their roles in mRNA destabilization and translational repression are well appreciated, their involvement in endonucleolytic cleavage of target RNAs is poorly ...
Bahn, Jae Hoon +7 more
core +2 more sources