Results 31 to 40 of about 411,003 (327)
Carbon Dots for Efficient Small Interfering RNA Delivery and Gene Silencing in Plants[OPEN]
Plant Physiology, 2020 The development of a formulation for siRNA delivery enables post-transcriptional gene silencing in plants with a simple spray application. The initiation of RNA interference (RNAi) by topically applied small interfering RNA has potential applications for
Steven H. Schwartz +4 more
semanticscholar +1 more source
Endogenous small interfering RNAs in animals [PDF]
Nature Reviews Molecular Cell Biology, 2008 Until recently, only nematodes among animals had a well-defined endogenous small interfering RNA (endo-siRNA) pathway. This has changed dramatically with the recent discovery of diverse intramolecular and intermolecular substrates that generate endo-siRNAs in Drosophila melanogaster and mice.
Eric C. Lai, Katsutomo Okamura
openaire +3 more sources
Medicinal Chemistry of Oligonucleotide Drugs - Milestones of the Past and Visions for the Future
CHIMIA, 2022 The oligonucleotide therapeutics field has blossomed in recent years, with thirteen approved drugs today and the promise of accelerated growth in coming years.
Jonathan Hall +7 more
doaj +1 more source
Therapeutic potential of small interfering RNAs/micro interfering RNA in hepatocellular carcinoma [PDF]
World Journal of Gastroenterology, 2015 Hepatocellular carcinoma (HCC) is the predominant form of primary liver cancer and represents the third leading cause of cancer-related death worldwide. Current available therapeutic approaches are poorly effective, especially for the advanced forms of the disease.
FARRA, ROSSELLA +3 more
openaire +4 more sources
Small interfering RNA against BCR-ABL transcripts sensitize mutated T315I cells to nilotinib
Haematologica, 2010 Background Selective inhibition of the BCR-ABL tyrosine kinase by RNA interference has been demonstrated in leukemic cells. We, therefore, evaluated specific BCR-ABL small interfering RNA silencing in BCR-ABL-positive cell lines, including those ...
Michael Koldehoff +3 more
doaj +1 more source
Computational Identification of Small Interfering RNA Targets in SARS-CoV-2
Virologica Sinica, 2020 With the epidemic of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) worldwide and in the absence of any effective vaccine, there is an urgent need to find a specific anti- SARS-CoV-2 agent.
Wei Chen +4 more
semanticscholar +1 more source
Heliyon, 2023 Objective: Colorectal cancer remains a significant challenge with high mortality rates. The aim of this study was to investigate the effect of targeting the microRNA-148a/WNT10b axis with the long non-coding RNA LINC00261 on the proliferation and ...
Juanli Xi +4 more
doaj
Short Hairpin RNAs for Strand-Specific Small Interfering RNA Production
Frontiers in Bioengineering and Biotechnology, 2020 RNA interference (RNAi) is an effective mechanism for inhibiting gene expression at the post-transcriptional level. Expression of a messenger RNA (mRNA) can be inhibited by a ∼22-nucleotide (nt) small interfering (si)RNA with the corresponding reverse ...
Peike Sheng +6 more
doaj +1 more source
The optimal concentration of siRNA for gene silencing in primary cultured astrocytes and microglial cells of rats [PDF]
Korean Journal of Anesthesiology, 2010 BackgroundSmall interfering RNAs (siRNAs) have been used to knockdown specific gene expression in various cells. Astrocytes and microglial cells play a key role in fundamental central nervous system functions and in chronic neuroinflammation. The aims of
Kyeong Ho Ki +5 more
doaj +1 more source
ACS Nano, 2019 The intracellular delivery of nucleic acids and proteins remains a key challenge in the development of biological therapeutics. In gene therapy, the inefficient delivery of small interfering RNA (siRNA) to the cytosol by lipoplexes or polyplexes is often
Marcin Wojnilowicz +4 more
semanticscholar +1 more source