Results 31 to 40 of about 417,785 (310)
Effect of silencing on proliferation and apoptosis of melanoma cells: An in vivo and in vitro study
Tumor Biology, 2017 This study aimed to investigate the effect of SOCS1 silencing on the proliferation and apoptosis of melanoma cells by in vivo and in vitro studies. Immunohistochemical staining was used to detect SOCS1 expression in melanoma tissues and pigmented nevi ...
Sheng-Jia Yu, Zi-Wen Long
doaj +1 more source
New Insight into Inter-kingdom Communication: Horizontal Transfer of Mobile Small RNAs
Frontiers in Microbiology, 2017 Small RNAs (sRNAs), including small interfering RNAs (siRNAs) and microRNAs (miRNAs), are conventionally regarded as critical molecular regulators of various intracellular processes.
Xi Chen, Geyu Zhou, Yu Zhou
doaj +1 more source
Characterization of the small RNA transcriptome of the diatom, Thalassiosira pseudonana. [PDF]
PLoS ONE, 2011 This study presents the first characterization of endogenous small RNAs in a diatom, Thalassiosira pseudonana. Small RNAs act as transcriptional and translational regulators, controlling specific target genes involved in various cellular functions ...
Trina M Norden-Krichmar +3 more
doaj +1 more source
Vascular endothelial‐cadherin as a marker of endothelial injury in preclinical Alzheimer disease
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1926-1940, December 2022., 2022 Abstract Objective Endothelial dysfunction is an early and prevalent pathology in Alzheimer disease (AD). We here investigate the value of vascular endothelial‐cadherin (VEC) as a cerebrospinal fluid (CSF) marker of endothelial injury in preclinical AD.
Rawan Tarawneh +5 more
wiley +1 more source
The specifics of small interfering RNA specificity [PDF]
Proceedings of the National Academy of Sciences, 2003 The discovery of transgene silencing in plants and double-stranded RNA (dsRNA) interference in the worm Caenorhabditis elegans has led to the latest revolution in molecular biology, RNA interference (RNAi). Over 10 years ago it was noted that several transgenic plant lines each containing the same ectopic transgene not only failed to be expressed but ...
openaire +3 more sources
Oligonucleotide Therapeutics: From Discovery and Development to Patentability
Pharmaceutics, 2022 Following the first proof of concept of using small nucleic acids to modulate gene expression, a long period of maturation led, at the end of the last century, to the first marketing authorization of an oligonucleotide-based therapy.
Lara Moumné +2 more
doaj +1 more source
Design of Small Interfering RNAs for Antiviral Applications [PDF]
, 2011 RNA interference (RNAi) is an evolutionarily conserved mechanism for sequence-specific target RNA degradation in animals and plants, which plays an essential role in gene regulation. In addition, it is believed to function as a defense against viruses and transposons. In recent years, RNAi has become a widely used approach for studying gene function by
Diana Rothe, Wade Erik, Jens Kurreck
openaire +3 more sources
Rotavirus gene silencing by small interfering RNAs [PDF]
EMBO reports, 2002 RNA interference is an evolutionarily conserved double‐stranded RNA‐triggered mechanism for suppressing gene expression. Rotaviruses, the leading cause of severe diarrhea in young children, are formed by three concentric layers of protein, from which the spike protein VP4 projects.
Susana López +3 more
openaire +3 more sources
Tumor Biology, 2017 Although gene therapy has brought new insights into the treatment of malignant melanoma, targeting delivery of nucleic acid which targets critical oncogene/anti-oncogene in vivo is still a bottleneck in the therapeutic application.
Hao Wang +7 more
doaj +1 more source
No two without three: Modelling dynamics of the trio RNA virus-defective interfering genomes-RNA satellite [PDF]
arXiv, 2023 Almost all viruses, regardless of their genomic material, produce defective viral genomes (DVG) as an unavoidable byproduct of their error-prone replication. Defective interfering (DI) elements are a subgroup of DVGs that have been shown to interfere with the replication of the wild-type (WT) virus.
arxiv