Results 41 to 50 of about 417,785 (310)
Delivering Small Interfering RNA for Novel Therapeutics [PDF]
, 2008 The gene silencing capability of RNA interference (RNAi) is being used to study individual gene's biological function and role in biochemical pathways. However, the efficacy of RNAi depends upon efficient delivery of the intermediates of RNAi, small interfering RNA (siRNA) oligonucleotides.
Patrick Y. Lu, Martin C. Woodle
openaire +3 more sources
Clinical Advances of siRNA-Based Nanotherapeutics for Cancer Treatment
Pharmaceutics, 2021 Cancer is associated with single or multiple gene defects. Recently, much research has focused on incorporating genetic materials as one of the means to treat various types of carcinomas.
Dima Hattab +2 more
doaj +1 more source
The application of antisense technology for crop improvement: A review
Cogent Food & Agriculture, 2021 The global population is increasing alarmingly, which calls for efficient methods of food production. Since domestication, people have been working on improving food crops for production and productivity.
Tadesse Tilahun +3 more
doaj +1 more source
cd26 Knockdown Negatively Affects Porcine Parthenogenetic Preimplantation Embryo Development
Animals, 2022 cd26 is ubiquitously distributed in the body, particularly in the endothelial and epithelial cells, with the highest expression in the kidney, liver, and small intestine. In humans, cd26 serves as a marker for the embryo implantation phase.
In-Sul Hwang +4 more
doaj +1 more source
Screening Genome Sequences for Known RNA Genes and Motifs [PDF]
, 2015 This methods paper presents computational protocols for the identification of non-coding RNA genes or RNA motifs within genomic sequences. An application to bacterial small RNA is proposed.
arxiv +1 more source
Predicting RNA-small molecule binding sites by 3D structure [PDF]
arXiv, 2023 The prediction of RNA-small molecule binding sites is crucial for the discovery of effective drugs. Various computational methods have been developed to address this challenge, using information about the structure and sequence of RNA. In this study, we introduce CplxCavity, a combination of a new algorithm and a machine learning model specifically ...
arxiv
Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
FEBS Letters, EarlyView.The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher +6 more
wiley +1 more source
Unraveling siRNA Unzipping Kinetics with Graphene [PDF]
, 2012 Using all atom molecular dynamics simulations, we report spontaneous unzipping and strong binding of small interfering RNA (siRNA) on graphene. Our dispersion corrected density functional theory based calculations suggest that nucleosides of RNA have stronger attractive interactions with graphene as compared to DNA residues. These stronger interactions
arxiv +1 more source
Small interfering RNA: potential in real-world clinical practice
Реальная клиническая практика: данные и доказательстваThis review describes the basics of protein biosynthesis and RNA interference processes, discusses the useful and unique properties of siRNA therapy, its advantages and disadvantages in comparison with other gene silencing methods, provides a brief ...
A. S. Motrinchuk, A. R. Kasimova
doaj +1 more source
Журнал инфектологии, 2014 Respiratory syncytial virus (RSV) is a major cause of morbidity in infants, young children, and the elderly worldwide. Presently, there are no explicit recommendations for RSV treatment apart from supportive care.
V. V. Vysochinskayа +5 more
doaj +1 more source