Results 1 to 10 of about 231,241 (299)

U8 variants on the brain: a small nucleolar RNA and human disease. [PDF]

RNA Biol, 2022
Small nucleolar RNAs (snoRNAs) are non-coding RNAs vital for ribosomal RNA (rRNA) maturation. The U8 snoRNA, encoded by the SNORD118 gene in humans, is an atypical C/D box snoRNA as it promotes rRNA cleavage rather than 2′–O–methylation and is unique to ...
McFadden EJ, Baserga SJ.
europepmc   +3 more sources

Are Small Nucleolar RNAs “CRISPRable”? A Report on Box C/D Small Nucleolar RNA Editing in Human Cells [PDF]

Frontiers in Pharmacology, 2019
CRISPR technologies are nowadays widely used for targeted knockout of numerous protein-coding genes and for the study of various processes and metabolic pathways in human cells. Most attention in the genome editing field is now focused on the cleavage of
J. Filippova, Anastasiya M Matveeva, E. Zhuravlev, E. Balakhonova, D. Prokhorova, Sergey Malanin, R. Shah Mahmud, T. V. Grigoryeva, Ksenia S. Anufrieva, D. Semenov, V. Vlassov, G. Stepanov   +11 more
semanticscholar   +7 more sources

Systematic pan-cancer analysis on the expression and role of regulator of chromatin condensation 1/small nucleolar RNA host gene 3/small nucleolar RNA host gene 12. [PDF]

Front Mol Biosci, 2022
Regulator of chromatin condensation 1 (RCC1) is the major guanine nucleotide exchange factor of RAN GTPase, which plays a key role in various biological processes such as cell cycle and DNA damage repair. Small nucleolar RNA host gene 3 (SNHG3) and small
Hu K, Yu H, Liu S, Liao D, Zhang Y.
europepmc   +2 more sources

Characterization of small nucleolar RNA retaining transcripts in human normal and cancer cells. [PDF]

Noncoding RNA Res
Small nucleolar RNAs are non-coding RNAs typically encoded within the introns of both protein-coding and non-coding genes. Interestingly, a significant fraction of snoRNA sequences is found as retained introns of specific mRNA isoforms expressed from ...
Rambaldelli G, Asghar S, Venturi G, Zacchini F, Serra M, Giovannini C, Gramantieri L, Bernini M, Inga A, Dassi E, Montanaro L.   +10 more
europepmc   +2 more sources

Small but strong: the emerging role of small nucleolar RNA in cardiovascular diseases. [PDF]

Front Cell Dev Biol, 2023
Cardiovascular diseases (CVDs) are the leading cause of mortality and disability worldwide. Numerous studies have demonstrated that non-coding RNAs (ncRNAs) play a primary role in CVD development.
Sun X, Wang G, Luo W, Gu H, Ma W, Wei X, Liu D, Jia S, Cao S, Wang Y, Yuan Z.   +10 more
europepmc   +2 more sources

Oncogenic Roles of Small Nucleolar RNA Host Gene 7 (SNHG7) Long Noncoding RNA in Human Cancers and Potentials. [PDF]

Front Cell Dev Biol, 2021
Long noncoding RNAs (lncRNAs) are a class of noncoding transcripts characterized with more than 200 nucleotides of length. Unlike their names, some short open reading frames are recognized for them encoding small proteins.
Najafi S, Ghafouri-Fard S, Hussen BM, Jamal HH, Taheri M, Hallajnejad M.   +5 more
europepmc   +2 more sources

Small Nucleolar RNA from <i>S. cerevisiae</i> Binds to Phosphatidylinositol 4,5-Bisphosphate. [PDF]

Noncoding RNA
Background: snoRNAs have traditionally been known for their role as guides in post-transcriptional rRNA modifications. Previously, our research group identified several RNAs that may bind to PIP2 with LIPRNA-seq.
Jiménez-Ramírez IA, Uc-Chuc MA, Zapata LCR, Castaño E.   +3 more
europepmc   +2 more sources

Long non‐coding small nucleolar RNA host genes in digestive cancers

Cancer Medicine, 2019
Although long noncoding RNAs (lncRNAs) do not have protein coding capacities, they are involved in the pathogenesis of many types of cancers, including hepatocellular carcinoma, cervical cancer, and gastric cancer. Notably, the roles of lncRNAs are vital
Huan Yang, Zheng Jiang, Shuang Wang, Yongbing Zhao, Xiaomei Song, Yufeng Xiao, Shiming Yang   +6 more
semanticscholar   +2 more sources

Enabling factor for cancer hallmark acquisition: Small nucleolar RNA host gene 17. [PDF]

Front Oncol, 2022
The role of long non-coding RNA (lncRNA) in human tumors has gradually received increasing attention in recent years. Particularly, the different functions of lncRNAs in different subcellular localizations have been widely investigated.
Zhang N, Sun Y, Wang T, Xu X, Cao M.
europepmc   +2 more sources

Long non-coding RNA small nucleolar RNA host gene 12 (SNHG12) promotes tumorigenesis and metastasis by targeting miR-199a/b-5p in hepatocellular carcinoma [PDF]

Journal of experimental & clinical cancer research : CR, 2017
Hepatocellular carcinoma (HCC) is third leading cause of cancer-related death globally. Evidence suggest that long non-coding RNAs (lncRNAs) have emerged as key regulators of tumorigenesis and metastasis in HCC.
Tian Lan, Weijie Ma, Zhenfei Hong, Long Wu, Xi Chen, Yufeng Yuan   +5 more
openalex   +2 more sources