Lactylation: From Homeostasis to Pathological Implications and Therapeutic Strategies
MedComm, Volume 6, Issue 6, June 2025.Lactylation, a novel post‐translational modification derived from lactate metabolism, plays a critical role in cellular homeostasis and disease pathogenesis. Under physiological conditions, lactylation regulates gene expression, immune responses, and metabolic adaptation. However, dysregulated lactylation is implicated in various pathological processes,
Xi Chen +6 more
wiley +1 more source
Multiple conserved segments of E1 small nucleolar RNA are involved in the formation of a ribonucleoprotein particle in frog oocytes [PDF]
, 2000 Donald D. RUHL +2 more
openalex +1 more source
Phase Separation: A New Dimension to Understanding Tumor Biology and Therapy
MedComm – Oncology, Volume 4, Issue 2, June 2025.Liquid–liquid phase separation (LLPS) facilitates the assembly of biomolecular condensates by leveraging weak multivalent interactions. The low‐complexity domains, foldable domains of proteins, and nucleic acids provide multivalent interaction sites among different molecules and contribute to the formation of condensates.
Xingwen Wang +4 more
wiley +1 more source
A Novel Brain-specific Box C/D Small Nucleolar RNA Processed from Tandemly Repeated Introns of a Noncoding RNA Gene in Rats [PDF]
, 2001 Jérôme Cavaillé +4 more
openalex +1 more source
Defective Processing of Cytoplasmic and Chloroplast Ribosomal RNA in the Absence of Arabidopsis DXO1
Plant, Cell &Environment, Volume 48, Issue 6, Page 4227-4244, June 2025.ABSTRACT Decapping 5′‐3′ exoribonucleases from the DXO/Rai1 family are highly conserved among eukaryotes and exhibit diverse enzymatic activities depending on the organism. The biochemical and structural properties of the plant DXO1 differ from the yeast and animal counterparts, which is reflected in the in vivo functions of this enzyme.
Monika Zakrzewska‐Placzek +5 more
wiley +1 more source
Telomere protein complexes and their role in lymphoid malignancies [PDF]
, 2017 Telomeres are highly regulated and dynamic complexes that protect the genomic DNA and prevent the end of linear chromosomes from being misrecognized as a broken DNA.
Dos Santos, Patricia Carolina +2 more
core
Suppression of small nucleolar RNA host gene 8 (SNHG8) inhibits the progression of colorectal cancer cells. [PDF]
Noncoding RNA Res, 2023 Islam Khan MZ, Law HKW.
europepmc +1 more source
NEW EMBO MEMBER'S REVIEW: Small nucleolar RNA-guided post-transcriptional modification of cellular RNAs [PDF]
, 2001 Tamás Kiss
openalex +1 more source
Analysis of Nucleolar Protein Dynamics Reveals the Nuclear Degradation of Ribosomal Proteins [PDF]
, 2007 Abovich +38 more
core +3 more sources