Results 31 to 40 of about 34,836 (187)
Ribosomal RNA: Small nucleolar RNAs make their mark [PDF]
Current Biology, 1996 Small nucleolar RNAs direct the location of certain methylations in ribosomal RNA by direct base pairing; although evolutionarily conserved, the physiological significance of these modifications remains unclear.
Peculis, Brenda A., Mount, Stephen M.
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Glutamine deficiency in solid tumor cells confers resistance to ribosomal RNA synthesis inhibitors
Nature Communications, 2022 Small molecules that target RNA Polymerase I inhibit ribosome biogenesis to activate p53 through the nucleolar surveillance response pathway. Here, the authors show that p53 induction by ribosome stress is dependent on extracellular glutamine ...
Melvin Pan +17 more
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On the nucleolar size and density in human early granulocytic progenitors, myeloblasts
European Journal of Histochemistry, 2009 Human myeloblasts were studied in bone marrow of patients suffering from chronic phase of chronic myeloid leukaemia to provide more information on the nucleolar diameter in these early granulocytic progenitors. These cells are a convenient model for such
K Smetana +4 more
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Nucleolar localization signals of Box H/ACA small nucleolar RNAs [PDF]
The EMBO Journal, 1999 The two major families of small nucleolar RNAs (snoRNAs), Box C/D and Box H/ACA, are generated in the nucleoplasm and transported to the nucleolus where they function in rRNA processing and modification. We have investigated the sequences involved in the intranuclear transport of Box H/ACA snoRNAs by assaying the localization of injected fluorescent ...
A, Narayanan +6 more
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Jouvence a small nucleolar RNA required in the gut extends lifespan in Drosophila
Nature Communications, 2020 Small non-coding RNAs contribute to the regulation of aging. Here the authors identify a small nucleolar RNA, the snoRNA jouvence, which extends the lifespan of fruit flies through its function in the gut, and is conserved in humans.
Stéphanie Soulé +4 more
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Evolution of small nucleolar RNAs in nematodes [PDF]
Nucleic Acids Research, 2006 In contrast to mRNAs, which are templates for translating proteins, non-protein coding (npc) RNAs (also known as 'non-coding' RNA, ncRNA), exhibit various functions in different compartments and developmental stages of the cell. Small nucleolar RNAs (snoRNAs), one of the largest classes of npcRNAs, guide post-transcriptional modifications of other RNAs
Zemann, Anja +4 more
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Open Life Sciences, 2020 Osteosarcoma is a common primary malignant bone cancer. Long noncoding RNA small nucleolar RNA host gene 15 (SNHG15) has been reported to play an oncogenic role in many cancers.
Zhang Jinshan +5 more
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Small Nucleolar RNAs Tell a Different Tale [PDF]
Trends in Genetics, 2019 Transcribing RNA Polymerase II interacts with multiple factors that orchestrate maturation and stabilisation of messenger RNA. For the majority of noncoding RNAs, the polymerase complex employs entirely different strategies, which usually direct the nascent transcript to ribonucleolytic degradation.
Kufel, Joanna, Grzechnik, Pawel
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Human snoRNA-93 is processed into a microRNA-like RNA that promotes breast cancer cell invasion
npj Breast Cancer, 2017 RNA: Small nucleolar-derived RNA contributes to tumor invasiveness A short microRNA-like fragment excised from a small nucleolar RNA (called a snoRNA-derived RNA or sdRNA) contributes to the invasiveness of breast cancer cells.
Dillon G. Patterson +23 more
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Cell Reports, 2017 Non-coding RNA biogenesis in higher eukaryotes has not been fully characterized. Here, we studied the Drosophila melanogaster Rexo5 (CG8368) protein, a metazoan-specific member of the DEDDh 3′-5′ single-stranded RNA exonucleases, by genetic, biochemical,
Stefanie Gerstberger +8 more
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