Results 31 to 40 of about 62,138 (272)

Expression profiling of snoRNAs in normal hematopoiesis and AML [PDF]

, 2018
Key Points A subset of snoRNAs is expressed in a developmental- and lineage-specific manner during human hematopoiesis. Neither host gene expression nor alternative splicing accounted for the observed differential expression of snoRNAs in ...
Helton, Nichole, Ley, Timothy J., Link, Daniel C., Spencer, David H., Trissal, Maria, Warner, Wayne A., White, Brian S.   +6 more
core   +2 more sources

Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration

Acta Neuropathologica Communications, 2017
An intronic GGGGCC expansion in C9orf72 is the most common known cause of both frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). The repeat expansion leads to the generation of sense and antisense repeat RNA aggregates and
Sarah Mizielinska, Charlotte E. Ridler, Rubika Balendra, Annora Thoeng, Nathan S. Woodling, Friedrich A. Grässer, Vincent Plagnol, Tammaryn Lashley, Linda Partridge, Adrian M. Isaacs   +9 more
doaj   +1 more source

Small RNA signatures of the anterior cruciate ligament from patients with knee joint osteoarthritis

Frontiers in Molecular Biosciences, 2023
Introduction: The anterior cruciate ligament (ACL) is susceptible to degeneration, resulting in joint pain, reduced mobility, and osteoarthritis development.
Yalda A. Kharaz, Danae E. Zamboulis, Yongxiang Fang, Tim J. M. Welting, Mandy J. Peffers, Eithne J. Comerford, Eithne J. Comerford   +6 more
doaj   +1 more source

Expression and Functional Studies on the Noncoding RNA, PRINS. [PDF]

, 2012
PRINS, a noncoding RNA identified earlier by our research group, contributes to psoriasis susceptibility and cellular stress response. We have now studied the cellular and histological distribution of PRINS by using in situ hybridization and demonstrated
Amin, Anikó Göblös, Attila Dobozy, Bata-Csorgo, Bata-Csorgo, Belso, Beylot-Barry, Borer, Bos, Bos, Bowcock, Bowcock, Carlen, Di Carlo, Duffy, Feuerstein, Feuerstein, Feuerstein, Feuerstein, Hernandez-Verdun, István Németh, Itahana, Krisztina Szegedi, Krueger, Kurki, Lajos Kemény, Lebwohl, Lee, Lindstrom, Livak, Mattick, Moll, Mária Antal, Márta Széll, Nomura, Palaniswamy, Papadopoulou, Peter, Pivarcsi, Pivarcsi, Polyanka, Rinn, Sarolta Bacsa, Sonkoly, Spector, Stoeckman, Szegedi, Szell, Szymanski, Takemura, Tarapore, Tiedge, Ting, Van Hooser, Wang, Wu, Yogev, Yusufzai, Zalfa, Zaric, Zhou, Zsuzsanna Bata-Csörgő   +61 more
core   +2 more sources

Small RNA expression and deep sequencing analyses of the nucleolus reveal the presence of nucleolus-associated microRNAs

FEBS Open Bio, 2014
Micro RNAs (miRNA) are non-coding RNAs expressed in the cytoplasm as their mature, 21–22-nucleotide short forms. More recently, mature miRNAs have also been detected in the nucleus, raising the possibility that their spatial distribution may be more ...
Baoyan Bai, Hester Liu, Marikki Laiho
doaj   +1 more source

Statement of Retraction: Knockdown of small nucleolar RNA host gene 10 (SNHG10) alleviates the injury of human neuroblastoma cells via the miR-1277-5p/insulin substrate receptor 2 axis. [PDF]

Bioengineered
europepmc   +3 more sources

Lithium alters expression of RNAs in a type-specific manner in differentiated human neuroblastoma neuronal cultures, including specific genes involved in Alzheimer's disease. [PDF]

, 2019
Lithium (Li) is a medication long-used to treat bipolar disorder. It is currently under investigation for multiple nervous system disorders, including Alzheimer's disease (AD).
Balaraman, Yokesh, Chopra, Nipun, Edenberg, Howard J, Kelsoe, John, Lahiri, Debomoy K, Liu, Yunlong, Maloney, Bryan, Nurnberger, John I   +7 more
core   +3 more sources

Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire [PDF]

, 2012
Idiosyncratic adverse drug reactions are unpredictable, dose independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve
A. Lucas, A. M. English, A. Sette, A. Wriston, B. J. Grant, B. Peters, C. A. F. de Oliveira, C. Oseroff, Cahalan, Chessman, Chung, D. A. Ostrov, D. F. Hunt, Day, E. Phillips, Faletto, Friesner, H. M. Grey, H. Mei, Harndahl, J. Jakoncic, J. Shabanowitz, J. Sidney, Ko, L. Shi, L. Yang, Lavergne, M. Harndahl, Mallal, Martin, Melroy, Phillips, Pichler, Rudolph, S. Buus, S. Lu, S. Mallal, S. Southwood, Shastri, Shimizu, Sidney, Sidney, Tenzer, Udeshi, Y. A. Pompeu, Yang, Yang, Yewdell   +47 more
core   +4 more sources

Ribosomal RNA: Small nucleolar RNAs make their mark [PDF]

Current Biology, 1996
Small nucleolar RNAs direct the location of certain methylations in ribosomal RNA by direct base pairing; although evolutionarily conserved, the physiological significance of these modifications remains unclear.
Peculis, Brenda A., Mount, Stephen M.
openaire   +2 more sources

Glutamine deficiency in solid tumor cells confers resistance to ribosomal RNA synthesis inhibitors

Nature Communications, 2022
Small molecules that target RNA Polymerase I inhibit ribosome biogenesis to activate p53 through the nucleolar surveillance response pathway. Here, the authors show that p53 induction by ribosome stress is dependent on extracellular glutamine ...
Melvin Pan, Christiane Zorbas, Maki Sugaya, Kensuke Ishiguro, Miki Kato, Miyuki Nishida, Hai-Feng Zhang, Marco M. Candeias, Akimitsu Okamoto, Takamasa Ishikawa, Tomoyoshi Soga, Hiroyuki Aburatani, Juro Sakai, Yoshihiro Matsumura, Tsutomu Suzuki, Christopher G. Proud, Denis L. J. Lafontaine, Tsuyoshi Osawa   +17 more
doaj   +1 more source