Results 31 to 40 of about 442,180 (329)
Ribosomal RNA: Small nucleolar RNAs make their mark [PDF]
Current Biology, 1996 Small nucleolar RNAs direct the location of certain methylations in ribosomal RNA by direct base pairing; although evolutionarily conserved, the physiological significance of these modifications remains unclear.
Brenda A. Peculis, Stephen M. Mount
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In vivo analysis of NHPX reveals a novel nucleolar localization pathway involving a transient accumulation in splicing speckles [PDF]
, 2002 The NHPX protein is a nucleolar factor that binds directly to a conserved RNA target sequence found in nucleolar box C/D snoRNAs and in U4 snRNA. Using enhanced yellow fluorescent protein (EYFP)– and enhanced cyan fluorescent protein–NHPX fusions, we ...
Lamond, Angus I., Leung, Anthony K. L.
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Nucleolar Localization of HIV-1 Rev Is Required, Yet Insufficient for Production of Infectious Viral Particles. [PDF]
, 2018 Combination antiretroviral therapy fails in complete suppression of HIV-1 due to drug resistance and persistent latency. Novel therapeutic intervention requires knowledge of intracellular pathways responsible for viral replication, specifically those ...
Arizala, Jerlisa Ann C +5 more
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Small RNA signatures of the anterior cruciate ligament from patients with knee joint osteoarthritis
Frontiers in Molecular Biosciences, 2023 Introduction: The anterior cruciate ligament (ACL) is susceptible to degeneration, resulting in joint pain, reduced mobility, and osteoarthritis development.
Yalda A. Kharaz +6 more
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Mapping targets for small nucleolar RNAs in yeast [PDF]
Wellcome Open Research, 2018 Background: Recent analyses implicate changes in the expression of the box C/D class of small nucleolar RNAs (snoRNAs) in several human diseases. Methods: Here we report the identification of potential novel RNA targets for box C/D snoRNAs in budding yeast, using the approach of UV crosslinking and sequencing of hybrids (CLASH) with the snoRNP proteins
Tatiana Dudnakova +3 more
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40S ribosome biogenesis co-factors are essential for gametophyte and embryo development [PDF]
, 2013 Ribosome biogenesis is well described in Saccharomyces cerevisiae. In contrast only very little information is available on this pathway in plants. This study presents the characterization of five putative protein co-factors of ribosome biogenesis in ...
Bohnsack, Markus T. +6 more
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Biology and applications of small nucleolar RNAs
Cellular and Molecular Life Sciences, 2011 Small nucleolar RNAs (snoRNAs) constitute a group of non-coding RNAs principally involved in posttranscriptional modification of ubiquitously expressed ribosomal and small nuclear RNAs. However, a number of tissue-specific snoRNAs have recently been identified that apparently do not target conventional substrates and are presumed to guide processing of
Tomaž Bratkovič, Boris Rogelj
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Cell, 2002 Small nucleolar RNAs represent an abundant, evolutionarily ancient group of noncoding RNAs which possess impressively diverse functions ranging from 2'-O-methylation and pseudouridylation of various classes of RNAs, through nucleolytic processing of rRNAs to the synthesis of telomeric DNA.
Tamás Kiss, Tamás Kiss
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Post-transcriptional Regulation of the U3 Small Nucleolar RNA [PDF]
Journal of Biological Chemistry, 2008 A high copy shuttle vector was used to express a "tagged" U3 small nucleolar RNA (snoRNA) gene in Schizosaccharomyces pombe to examine regulatory responses to a high gene dosage. RNA analyses utilizing reverse transcription-PCR amplification and restriction fragment length polymorphism indicated that the tagged gene was both proportionally and highly ...
Sadegh Nabavi +2 more
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Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration
Acta Neuropathologica Communications, 2017 An intronic GGGGCC expansion in C9orf72 is the most common known cause of both frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). The repeat expansion leads to the generation of sense and antisense repeat RNA aggregates and
Sarah Mizielinska +9 more
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