Human snoRNA-93 is processed into a microRNA-like RNA that promotes breast cancer cell invasion
npj Breast Cancer, 2017 RNA: Small nucleolar-derived RNA contributes to tumor invasiveness A short microRNA-like fragment excised from a small nucleolar RNA (called a snoRNA-derived RNA or sdRNA) contributes to the invasiveness of breast cancer cells.
Dillon G. Patterson +23 more
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Cell Reports, 2017 Non-coding RNA biogenesis in higher eukaryotes has not been fully characterized. Here, we studied the Drosophila melanogaster Rexo5 (CG8368) protein, a metazoan-specific member of the DEDDh 3′-5′ single-stranded RNA exonucleases, by genetic, biochemical,
Stefanie Gerstberger +8 more
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Dual Requirement for Yeast hnRNP Nab2p in mRNA poly(A) Tail Length Control and Nuclear Export [PDF]
, 2002 Recent studies of mRNA export factors have provided additional evidence for a mechanistic link between mRNA 3′‐end formation and nuclear export. Here, we identify Nab2p as a nuclear poly(A)‐binding protein required for both poly(A) tail length control ...
Anderson, James T. +8 more
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Identification of additional regulatory RNPs that impact rRNA and U6 snRNA methylation
Biology Open, 2018 Ribosomes can be heterogeneous, and the major contributor to ribosome heterogeneity is variation in rRNA modification. There are two major types of rRNA modification, pseudouridylation and ribose methylation.
Marilyn F. Burke +2 more
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Loss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis
Nature Communications, 2021 Lipid induced stress contributes to metabolic diseases. Here the authors identify small nucleolar RNA 73 (SNORA73) in a screen for genes that protect against lipotoxicity and show that deficiency of SNORA73 reprograms oxidative metabolism and protects ...
Arthur C. Sletten +13 more
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Characterization of nuclear polyadenylated RNA-binding proteins in Saccharomyces cerevisiae. [PDF]
, 1994 To study the functions of heterogeneous nuclear ribonucleoproteins (hnRNPs), we have characterized nuclear polyadenylated RNA-binding (Nab) proteins from Saccharomyces cerevisiae.
Datar, KV +4 more
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Diverse human extracellular RNAs are widely detected in human plasma
Nature Communications, 2016 Extracellular miRNAs are present in a variety of bodily fluids. Here, Freedman et al. analysed plasma-derived RNA by RNA-seq from 40 people followed by targeted RT-qPCR in an additional 2,763 people, and report over 1,000 extracellular RNAs including ...
Jane E. Freedman +19 more
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Molecular determinants that govern scaRNA processing by Drosha/DGCR8
Biology Open, 2020 The Cajal body (CB) is a subnuclear domain that participates in the biogenesis of many different types of ribonucleoproteins (RNPs), including small nuclear RNPs (snRNPs), small Cajal body-specific RNPs (scaRNPs) and telomerase.
Douglas M. McLaurin +3 more
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LncRNA SNHG1: role in tumorigenesis of multiple human cancers
Cancer Cell International, 2023 Small nucleolar RNA host gene 1 (SNHG1) is an important member of the SNHG family. This family is composed of a group of host genes that can be processed into small nucleolar RNAs and play important biological functions.
Huang Zeng +4 more
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SnoRNA and lncSNHG: Advances of nucleolar small RNA host gene transcripts in anti-tumor immunity
Frontiers in Immunology, 2023 The small nucleolar RNA host genes (SNHGs) are a group of genes that can be transcript into long non-coding RNA SNHG (lncSNHG) and further processed into small nucleolar RNAs (snoRNAs).
Hao Xiao +9 more
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