Results 171 to 180 of about 1,407,145 (245)

Phage-encoded small RNA hijacks host replication machinery to support the phage lytic cycle. [PDF]

Mol Cell
Silverman A, Nashef R, Wasserman R, Noy T, Born S, Yao T, Geng Y, Rotbard H, Levkowitz A, Kaufman Y, Golding I, Melamed S.   +11 more
europepmc   +1 more source

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source

3'UTR-derived small RNA couples acid resistance to metabolic reprogramming of Salmonella within macrophages. [PDF]

Nucleic Acids Res
Kanda T, Liu F, Kooshapour H, Reichardt S, Wang M, Icyishaka P, Obana N, Westermann AJ, Chao Y, Miyakoshi M.   +9 more
europepmc   +1 more source

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

Caloric restriction modifies small RNA profiles and engages age-related molecular pathways in the CALERIE trial. [PDF]

iScience
Orenduff MC, Huffman KM, Belsky DW, Pieper CF, Kraus WE, Kraus VB, CALERIE™ Investigators.   +6 more
europepmc   +1 more source

Adult‐Onset Subacute Sclerosing Panencephalitis Presenting With Subacute Cognitive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We describe the case of a 41‐year‐old man diagnosed with adult‐onset subacute sclerosing panencephalitis (SSPE). The patient presented with subacute progressive cognitive deficits and a neuropsychological profile indicating predominant frontoparietal dysfunction. MRI showed only mild parietal‐predominant cerebral atrophy.
Dennis Yeow, Nicola McKern, Vincent Oxenham, Kate Ahmad, Omar Ahmad   +4 more
wiley   +1 more source

Defining RNA–Small Molecule Affinity Landscapes Enables Design of a Small Molecule Inhibitor of an Oncogenic Noncoding RNA

ACS Central Science, 2017
Sai Pradeep Velagapudi, Yiling Luo, Tuan Tran, Hafeez S. Haniff, Yoshio Nakai, Mohammad Fallahi, Gustavo J. Martinez, Jessica L. Childs-Disney, Matthew D. Disney   +8 more
doaj   +1 more source

Antagonism in Orthotospoviruses Is Reflected in Plant Small RNA Profile. [PDF]

Viruses
Islam MT, Zhao K, Johnson N, Axtell M, Rosa C.   +4 more
europepmc   +1 more source

Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa, Iago Pinal‐Fernandez, Pritikanta Paul, Michael P. Skolka, Margherita Milone, Min Shi, Mithun V. Shah, Maria Casal‐Dominguez, Katherine Pak, Andrew L. Mammen, Teerin Liewluck   +10 more
wiley   +1 more source

Small RNA-Seq Reveals the Effect of Formaldehyde Treatment on Chicken Embryo Liver microRNA Profiles. [PDF]

Int J Mol Sci
Teber S, Özdemir M, Sajid GA, Büyükkılıç Beyzi S, Kizilaslan M, Arzık Y, Yalçın S, White SN, Cinar MU.   +8 more
europepmc   +1 more source