Vaccinia Virus: From Crude Smallpox Vaccines to Elaborate Viral Vector Vaccine Design [PDF]
Biomedicines, 2021 Various vaccinia virus (VACV) strains were applied during the smallpox vaccination campaign to eradicate the variola virus worldwide. After the eradication of smallpox, VACV gained popularity as a viral vector thanks to increasing innovations in genetic ...
Onur Kaynarcalidan +2 more
doaj +3 more sources
Global perspectives on smallpox vaccine against monkeypox: a comprehensive meta-analysis and systematic review of effectiveness, protection, safety and cross-immunogenicity [PDF]
Emerging Microbes and InfectionsA large outbreak of monkeypox occurred in 2022, and most people lack immunity to orthopoxvirus. Smallpox vaccination is essential for preventing further smallpox outbreaks.
Hao Liu +7 more
doaj +3 more sources
Use of JYNNEOS (Smallpox and Monkeypox Vaccine, Live, Nonreplicating) for Preexposure Vaccination of Persons at Risk for Occupational Exposure to Orthopoxviruses: Recommendations of the Advisory Committee on Immunization Practices — United States, 2022 [PDF]
MMWR. Morbidity and mortality weekly report, 2022 Certain laboratorians and health care personnel can be exposed to orthopoxviruses through occupational activities. Because orthopoxvirus infections resulting from occupational exposures can be serious, the Advisory Committee on Immunization Practices ...
Agam K. Rao +10 more
openalex +2 more sources
BMC Microbiology, 2021 Background Anthrax and smallpox are high-risk infectious diseases, and considered as potential agents for bioterrorism. To develop an effective countermeasure for these diseases, we constructed a bivalent vaccine against both anthrax and smallpox by ...
Deok Bum Park +9 more
doaj +2 more sources
Genome Biology, 2020 According to a recent article published in Genome Biology, Duggan and coworkers sequenced and partially assembled five genomes of smallpox vaccines from the nineteenth century.
Annika Brinkmann +4 more
doaj +2 more sources
The origins and genomic diversity of American Civil War Era smallpox vaccine strains
Genome Biology, 2020 Vaccination has transformed public health, most notably including the eradication of smallpox. Despite its profound historical importance, little is known of the origins and diversity of the viruses used in smallpox vaccination.
Ana T. Duggan +21 more
doaj +2 more sources
Immunogenicity and safety of three consecutive production lots of the non replicating smallpox vaccine MVA: A randomised, double blind, placebo controlled phase III trial [PDF]
PLoS ONE, 2018 BackgroundModified Vaccinia Ankara (MVA) is a live, viral vaccine under advanced development as a non-replicating smallpox vaccine. A randomised, double-blind, placebo-controlled phase III clinical trial was conducted to demonstrate the humoral ...
Chaplin, Paul +12 more
core +4 more sources
Japanese journal of infectious diseases (Print), 2016 Monkeypox virus (MPXV) causes human monkeypox (human MPX), which is a similar disease to smallpox in humans. A previous study showed that a single vaccination of monkeys with LC16m8, a highly attenuated smallpox vaccine, protected them from MPX from 4-5 ...
Itoe Iizuka +10 more
openalex +3 more sources
Journal of the European Academy of Dermatology and Venereology, 2016 Ulf Darsow +6 more
openalex +2 more sources
Impaired innate, humoral, and cellular immunity despite a take in smallpox vaccine recipients
Vaccine, 2016 Richard B. Kennedy +7 more
openalex +3 more sources