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Global perspectives on smallpox vaccine against monkeypox: a comprehensive meta-analysis and systematic review of effectiveness, protection, safety and cross-immunogenicity [PDF]

Emerging Microbes and Infections
A large outbreak of monkeypox occurred in 2022, and most people lack immunity to orthopoxvirus. Smallpox vaccination is essential for preventing further smallpox outbreaks.
Hao Liu, Wenjing Wang, Yang Zhang, Fuchun Wang, Junyi Duan, Tao Huang, Xiaojie Huang, Tong Zhang   +7 more
doaj   +3 more sources

Vaccinia Virus: From Crude Smallpox Vaccines to Elaborate Viral Vector Vaccine Design [PDF]

Biomedicines, 2021
Various vaccinia virus (VACV) strains were applied during the smallpox vaccination campaign to eradicate the variola virus worldwide. After the eradication of smallpox, VACV gained popularity as a viral vector thanks to increasing innovations in genetic ...
Onur Kaynarcalidan, Sara Moreno Mascaraque, Ingo Drexler   +2 more
doaj   +3 more sources

The origins and genomic diversity of American Civil War Era smallpox vaccine strains [PDF]

Genome Biology, 2020
Vaccination has transformed public health, most notably including the eradication of smallpox. Despite its profound historical importance, little is known of the origins and diversity of the viruses used in smallpox vaccination.
Ana T. Duggan, Jennifer Klunk, Ashleigh F. Porter, Anna N. Dhody, Robert Hicks, Geoffrey L. Smith, Margaret Humphreys, Andrea M. McCollum, Whitni B. Davidson, Kimberly Wilkins, Yu Li, Amanda Burke, Hanna Polasky, Lowell Flanders, Debi Poinar, Amogelang R. Raphenya, Tammy T. Y. Lau, Brian Alcock, Andrew G. McArthur, G. Brian Golding, Edward C. Holmes, Hendrik N. Poinar   +21 more
doaj   +3 more sources

Re-assembly of nineteenth-century smallpox vaccine genomes reveals the contemporaneous use of horsepox and horsepox-related viruses in the USA [PDF]

Genome Biology, 2020
According to a recent article published in Genome Biology, Duggan and coworkers sequenced and partially assembled five genomes of smallpox vaccines from the nineteenth century.
Annika Brinkmann, Aline R. V. Souza, José Esparza, Andreas Nitsche, Clarissa R. Damaso   +4 more
doaj   +3 more sources

Possible Mpox Protection from Smallpox Vaccine-Generated Antibodies among Older Adults. [PDF]

Emerg Infect Dis, 2023
Smallpox vaccination may confer cross-protection to mpox. We evaluated vaccinia virus antibodies in 162 persons ≥50 years of age in Spain; 68.5% had detectable antibodies. Highest coverage (78%) was among persons 71–80 years of age.
Sanz-Muñoz I, Sánchez-dePrada L, Sánchez-Martínez J, Rojo-Rello S, Domínguez-Gil M, Hernán-García C, Fernández-Espinilla V, de Lejarazu-Leonardo RO, Castrodeza-Sanz J, Eiros JM.   +9 more
europepmc   +2 more sources

An open-label, non-randomized study investigating the safety and efficacy of smallpox vaccine, LC16, as post-exposure prophylaxis for mpox. [PDF]

Hum Vaccin Immunother, 2023
Mpox is an acute exanthematous disease caused by the monkeypox virus. Since May 2022, it has spread as a community-acquired infection, mainly in Europe and the United States, and urgent measures to prevent this infection were also required in Japan.
Tomita N, Terada-Hirashima J, Uemura Y, Shimizu Y, Iwasaki H, Yano R, Suzuki T, Saito S, Okumura N, Sugiura W, Ohmagari N, Ujiie M.   +11 more
europepmc   +2 more sources

Safety and Efficacy of Post-Eradication Smallpox Vaccine as an Mpox Vaccine: A Systematic Review with Meta-Analysis. [PDF]

Int J Environ Res Public Health, 2023
According to the World Health Organization, 83,339 laboratory-confirmed cases, including 72 deaths, of mpox (formerly known as monkeypox), have been reported from 110 locations globally as of 20 December 2022, making the disease a public health concern ...
Malone SM, Mitra AK, Onumah NA, Brown A, Jones LM, Tresvant D, Brown CS, Onyia AU, Iseguede FO.   +8 more
europepmc   +2 more sources

Monkeypox in Patient Immunized with ACAM2000 Smallpox Vaccine During 2022 Outbreak. [PDF]

Emerg Infect Dis, 2022
We report a case of monkeypox in the United States in a patient who had been vaccinated with ACAM2000 smallpox vaccine 8 years earlier. Despite his vaccination status, he still contracted disease.
Turner M, Mandia J, Keltner C, Haynes R, Faestel P, Mease L.   +5 more
europepmc   +2 more sources

Mpox outbreak in the Netherlands, 2022: public health response, characteristics of the first 1,000 cases and protection of the first-generation smallpox vaccine. [PDF]

Euro Surveill, 2023
In early May 2022, a global outbreak of mpox started among persons without travel history to regions known to be enzootic for monkeypox virus (MPXV). On 8 August 2022, the Netherlands reported its 1,000th mpox case, representing a cumulative incidence of
van Ewijk CE, Miura F, van Rijckevorsel G, de Vries HJ, Welkers MR, van den Berg OE, Friesema IH, van den Berg PR, Dalhuisen T, Wallinga J, Brandwagt D, van Cleef BA, Vennema H, Voordouw B, Koopmans M, van der Eijk AA, Swaan CM, Te Wierik MJ, Leenstra T, Op de Coul E, Franz E, Dutch Mpox Response Team, Members of the Dutch Mpox Response Team.   +22 more
europepmc   +2 more sources

Evaluating immunogenicity of pathogen-derived T-cell epitopes to design a peptide-based smallpox vaccine. [PDF]

Sci Rep, 2022
Despite the eradication in 1980, developing safe and effective smallpox vaccines remains an active area of research due to the recent outbreaks and the public health concern that smallpox viruses could be used as bioterrorism weapons.
Quach HQ, Ovsyannikova IG, Poland GA, Kennedy RB.   +3 more
europepmc   +2 more sources