Results 31 to 40 of about 636,626 (282)

Monkeypox vaccine – Current status

Journal of Integrative Medicine and Research, 2023
From a long time ago, there have been intermittent outbreaks of the zoonotic disease monkeypox (mpox) throughout Africa. The first case of human mpox was documented in 1970 in rural Congo. Mpox was classified as a Public Health Emergency of International
Brig Ambika Mohanty, Aroop Mohanty
doaj   +1 more source

Low-Temperature Multiple Micro-Dispensing on Microneedles for Accurate Transcutaneous Smallpox Vaccination

Vaccines, 2022
Smallpox is an acute contagious disease caused by the variola virus. According to WHO guidelines, the smallpox vaccine is administrated by scarification into the epidermis using a bifurcated needle moistened with a vaccine solution.
Sang-Gu Yim, Yun-Ho Hwang, Seonyeong An, Keum-Yong Seong, Seo-Yeon Kim, Semin Kim, Hyeseon Lee, Kang-Oh Lee, Mi-Young Kim, Dokeun Kim, You-Jin Kim, Seung-Yun Yang   +11 more
doaj   +1 more source

Effect of prior immunisation with smallpox vaccine for protection against human Mpox: A systematic review

Reviews in Medical Virology, 2023
Monkeypox is an emerging threat to humans since a new outbreak in May 2022. It is hypothesised that increasing the immunologically naive population after the cessation of the smallpox vaccination campaign in the 1980s is one of the leading causes of it ...
Fahima Akter, Tahira Binte Hasan, Farhana Alam, Aurpy Das, Shanta Afrin, Sadia Maisha, A. Masud, Saif-Ur-Rahman Km   +7 more
semanticscholar   +1 more source

The two-dose MVA-BN mpox vaccine induces a nondurable and low avidity MPXV-specific antibody response

Journal of Virology
The 2022 global outbreak of clade IIb mpox was the first major outbreak of mpox outside of African nations. To control the outbreak, public health officials began vaccination campaigns using the third-generation orthopoxvirus vaccine modified vaccinia ...
Aaron L. Oom, Kesi K. Wilson, Miilani Yonatan, Stephanie Rettig, Heekoung Allison Youn, Michael Tuen, Yusra Shah, Ashley L. DuMont, Hayley M. Belli, Jane R. Zucker, Jennifer B. Rosen, Ramin Sedaghat Herati, Marie I. Samanovic, Ralf Duerr, Angelica C. Kottkamp, Mark J. Mulligan   +15 more
doaj   +2 more sources

Immunomodulator-based enhancement of anti smallpox immune responses. [PDF]

PLoS ONE, 2015
BACKGROUND:The current live vaccinia virus vaccine used in the prevention of smallpox is contraindicated for millions of immune-compromised individuals. Although vaccination with the current smallpox vaccine produces protective immunity, it might result ...
Osmarie Martínez, Eric Miranda, Maite Ramírez, Saritza Santos, Carlos Rivera, Luis Vázquez, Tomás Sánchez, Raymond L Tremblay, Eddy Ríos-Olivares, Miguel Otero   +9 more
doaj   +1 more source

Development of a Multi-Epitope Universal mRNA Vaccine Candidate for Monkeypox, Smallpox, and Vaccinia Viruses: Design and In Silico Analyses

Viruses, 2023
Notwithstanding the presence of a smallpox vaccine that is effective against monkeypox (mpox), developing a universal vaccine candidate against monkeypox virus (MPXV) is highly required as the mpox multi-country outbreak has increased global concern ...
N. Rcheulishvili, J. Mao, Dimitri Papukashvili, Shunping Feng, Cong Liu, Xidan Yang, Jihui Lin, Yunjiao He, Peng George Wang   +8 more
semanticscholar   +1 more source

Multi-epitope mRNA Vaccine Design that Exploits Variola Virus and Monkeypox Virus Proteins for Elicitation of Long-lasting Humoral and Cellular Protection Against Severe Disease

Journal of Medical Science, 2022
Human monkeypox represents a relatively underexplored infection that has received increased attention since the reported outbreak in May 2022. Due to its clinical similarities with human smallpox, this virus represents a potentially tremendous health ...
Dženan Kovačić, Adna Salihović
doaj   +1 more source

Prevention and Treatment of Monkeypox: A Systematic Review of Preclinical Studies

Viruses, 2022
The outbreak of monkeypox, coupled with the onslaught of the COVID-19 pandemic is a critical communicable disease. This study aimed to systematically identify and review research done on preclinical studies focusing on the potential monkeypox treatment ...
Nurizzati Sudarmaji, Nurolaini Kifli, Andi Hermansyah, Siang Fei Yeoh, Bey-Hing Goh, Long Chiau Ming   +5 more
doaj   +1 more source

Monkeypox Virus: Epidemiology, Virology, Diagnosis, Vaccine, and Therapeutics. [PDF]

MedComm (2020)
This review provides a comprehensive overview of the latest research advances in MPXV, with a focused analysis across five core dimensions: epidemiology, virology, diagnosis, vaccine, and therapeutics. The primary objective of this review is to advance the understanding of MPXV and facilitate the development of more effective diagnostic methods ...
Yan Y, Sun Y, Sun G, Niu C, Zhao X, Zhao M, Liu T, Zhang S, Zhai H, Liu A, Yu S, Pan S, Zhong W, Zhang Y, Li S.   +14 more
europepmc   +2 more sources

The role of research in viral disease eradication and elimination programs: Lessons for malaria eradication [PDF]

, 2011
By examining the role research has played in eradication or regional elimination initiatives for three viral diseases-smallpox, poliomyelitis, and measles-we derive nine cross-cutting lessons applicable to malaria eradication.
Breman, JG, de Quadros, CA, Dowdle, WR, Foege, WH, Henderson, DA, John, TJ, Levine, MM   +6 more
core   +1 more source