Results 41 to 50 of about 4,972 (128)

Binding of the heterogeneous ribonucleoprotein K (hnRNP K) to the Epstein-Barr virus nuclear antigen 2 (EBNA2) enhances viral LMP2A expression. [PDF]

PLoS ONE, 2012
The Epstein-Barr Virus (EBV) -encoded EBNA2 protein, which is essential for the in vitro transformation of B-lymphocytes, interferes with cellular processes by binding to proteins via conserved sequence motifs.
Henrik Gross, Christine Hennard, Ilias Masouris, Christian Cassel, Stephanie Barth, Ute Stober-Grässer, Alfredo Mamiani, Bodo Moritz, Dirk Ostareck, Antje Ostareck-Lederer, Nils Neuenkirchen, Utz Fischer, Wen Deng, Heinrich Leonhardt, Elfriede Noessner, Elisabeth Kremmer, Friedrich A Grässer   +16 more
doaj   +1 more source

The Survival of Motor Neuron Protein Acts as a Molecular Chaperone for mRNP Assembly

Cell Reports, 2017
Spinal muscular atrophy (SMA) is a motor neuron disease caused by reduced levels of the survival of motor neuron (SMN) protein. SMN is part of a multiprotein complex that facilitates the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs).
Paul G. Donlin-Asp, Claudia Fallini, Jazmin Campos, Ching-Chieh Chou, Megan E. Merritt, Han C. Phan, Gary J. Bassell, Wilfried Rossoll   +7 more
doaj   +1 more source

The Ribosome Cooperates with the Assembly Chaperone pICln to Initiate Formation of snRNPs

Cell Reports, 2016
The formation of macromolecular complexes within the crowded environment of cells often requires aid from assembly chaperones. PRMT5 and SMN complexes mediate this task for the assembly of the common core of pre-mRNA processing small nuclear ...
Elham Paknia, Ashwin Chari, Holger Stark, Utz Fischer   +3 more
doaj   +1 more source

Schizophrenia gene networks and pathways and their applications for novel candidate gene selection. [PDF]

PLoS ONE, 2010
Schizophrenia (SZ) is a heritable, complex mental disorder. We have seen limited success in finding causal genes for schizophrenia from numerous conventional studies.
Jingchun Sun, Peilin Jia, Ayman H Fanous, Edwin van den Oord, Xiangning Chen, Brien P Riley, Richard L Amdur, Kenneth S Kendler, Zhongming Zhao   +8 more
doaj   +1 more source

Composition of the Survival Motor Neuron (SMN) Complex in Drosophila melanogaster

G3: Genes, Genomes, Genetics, 2019
Spinal Muscular Atrophy (SMA) is caused by homozygous mutations in the human survival motor neuron 1 (SMN1) gene. SMN protein has a well-characterized role in the biogenesis of small nuclear ribonucleoproteins (snRNPs), core components of the spliceosome.
A. Gregory Matera, Amanda C. Raimer, Casey A. Schmidt, Jo A. Kelly, Gaith N. Droby, David Baillat, Sara ten Have, Angus I. Lamond, Eric J. Wagner, Kelsey M. Gray   +9 more
doaj   +1 more source

The Cajal body protein p80-coilin forms a complex with the adenovirus L4-22K protein and facilitates the nuclear export of adenovirus mRNA

mBio, 2023
Cajal bodies (CBs) are major sub-nuclear structures in most eucaryotic cells. In human adenovirus 5 (Ad5) infection, CBs are reorganized into microfoci in the late phase of infection.
Laura White, Bilgi Erbay, G. Eric Blair
doaj   +1 more source

Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes.

The Journal of biological chemistry, 2005
The survival of motor neurons (SMN) complex mediates the assembly of small nuclear ribonucleoproteins (snRNPs) involved in splicing and histone RNA processing. A crucial step in this process is the binding of Sm proteins onto the SMN protein. For Sm B/B', D1, and D3, efficient binding to SMN depends on symmetrical dimethyl arginine (sDMA) modifications
Azzouz, T., Pillai, R., Däpp, C., Chari, A., Meister, G., Kambach, C., Fischer, U., Schümperli, D.   +7 more
openaire   +4 more sources

The Small-Molecule Flunarizine in Spinal Muscular Atrophy Patient Fibroblasts Impacts on the Gemin Components of the SMN Complex and TDP43, an RNA-Binding Protein Relevant to Motor Neuron Diseases

Frontiers in Molecular Biosciences, 2020
The motor neurodegenerative disease spinal muscular atrophy (SMA) is caused by alterations of the survival motor neuron 1 (SMN1) gene involved in RNA metabolism. Although the disease mechanisms are not completely elucidated, SMN protein deficiency leads to abnormal small nuclear ribonucleoproteins (snRNPs) assembly responsible for widespread splicing ...
Sapaly, Delphine, Delers, Perrine, Coridon, Jennifer, Salman, Badih, Letourneur, Franck, Dumont, Florent, Lefebvre, Suzie   +6 more
openaire   +3 more sources

GEMINs: Potential Therapeutic Targets for Spinal Muscular Atrophy?

Frontiers in Neuroscience, 2014
The motor neuron degenerative disease spinal muscular atrophy (SMA) remains one of the most frequently inherited causes of infant mortality. Afflicted patients loose the survival motor neuron 1 (SMN1) gene but retain one or more copies of SMN2, a ...
Rebecca eBorg, Ruben J Cauchi
doaj   +1 more source

Accurate prediction of peptide binding sites on protein surfaces. [PDF]

PLoS Computational Biology, 2009
Many important protein-protein interactions are mediated by the binding of a short peptide stretch in one protein to a large globular segment in another.
Evangelia Petsalaki, Alexander Stark, Eduardo García-Urdiales, Robert B Russell, Robert B Russell   +4 more
doaj   +1 more source