Microstructural analysis of skeletal muscle force generation during aging. [PDF]
, 2020 Human aging results in a progressive decline in the active force generation capability of skeletal muscle. While many factors related to the changes of morphological and structural properties in muscle fibers and the extracellular matrix (ECM) have been ...
Basava, Ramya R +7 more
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MicroRNAs in pulmonary arterial remodeling [PDF]
, 2013 Pulmonary arterial remodeling is a presently irreversible pathologic hallmark of pulmonary arterial hypertension (PAH). This complex disease involves pathogenic dysregulation of all cell types within the small pulmonary arteries contributing to vascular ...
A Courboulin +137 more
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Frontiers in Physiology, 2023 Exposure to hypoxia, due to high altitude or chronic lung disease, leads to structural changes in the pulmonary vascular wall, including hyperplasia and migration of pulmonary arterial smooth muscle cells (PASMCs).
Julie M. Lade +6 more
doaj +1 more source
Tensin1 expression and function in chronic obstructive pulmonary disease [PDF]
, 2019 open access articleChronic obstructive pulmonary disease (COPD) constitutes a major cause of morbidity and mortality. Genome wide association studies have shown significant associations between airflow obstruction or COPD with a non-synonymous SNP in ...
Amrani, Y. +7 more
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Specialized mouse embryonic stem cells for studying vascular development. [PDF]
, 2014 Vascular progenitor cells are desirable in a variety of therapeutic strategies; however, the lineage commitment of endothelial and smooth muscle cell from a common progenitor is not well-understood.
Burns, Andrew B +5 more
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Ablation of smooth muscle myosin heavy chain SM2 increases smooth muscle contractility and results in postnatal death in mice [PDF]
, 2008 The smooth muscle myosin heavy chains (SMHC) are motor proteins powering smooth muscle contraction. Alternate splicing of SHMC gene at the C-terminus produces SM1, and SM2 myosin isoforms; SM2 (200 kDa) contains a unique 9-amino-acid sequence at the ...
Aikawa +22 more
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Caveolin-3 promotes a vascular smooth muscle contractile phenotype
Frontiers in Cardiovascular Medicine, 2015 Epidemiological studies have demonstrated the importance of cardiovascular diseases in Western countries. Among the cell types associated with a dysfunctional vasculature, smooth muscle cells are believed to play an essential role in the development of ...
Jorge L. Gutierrez-Pajares +8 more
doaj +1 more source
Development and Application of a Functional Human Esophageal Mucosa Explant Platform to Eosinophilic Esophagitis. [PDF]
, 2019 There is an increasing prevalence of esophageal diseases but intact human tissue platforms to study esophageal function, disease mechanisms, and the interactions between cell types in situ are lacking.
Aceves, Seema S +12 more
core +3 more sources
Regulation of human airway smooth muscle cell migration and relevance to asthma
Respiratory Research, 2017 Airway remodelling is an important feature of asthma pathogenesis. A key structural change inherent in airway remodelling is increased airway smooth muscle mass.
Brittany Salter +4 more
doaj +1 more source
Identification of a rhythmic firing pattern in the enteric nervous system that generates rhythmic electrical activity in smooth muscle [PDF]
, 2018 The enteric nervous system (ENS) contains millions of neurons essential for organization of motor behavior of the intestine. It is well established that the large intestine requires ENS activity to drive propulsive motor behaviors.
Brookes, Simon J +10 more
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