Results 41 to 50 of about 920,258 (356)

MicroRNAs in pulmonary arterial remodeling [PDF]

, 2013
Pulmonary arterial remodeling is a presently irreversible pathologic hallmark of pulmonary arterial hypertension (PAH). This complex disease involves pathogenic dysregulation of all cell types within the small pulmonary arteries contributing to vascular ...
A Courboulin, A Eulalio, A Ishisaki, A Jelaska, A Kos, A Sacconi, A Tanzer, A Zampetaki, A Zampetaki, AE Frost, AJ Tijsen, AM Walker, Andrew H. Baker, AR Kuhn, AS Flynt, AY Rangrez, AY Yu, B Wojciak-Stothard, BD Adams, BN Davis, BN Davis-Dusenbery, C Atkinson, C Li, C Sweeney, CA Klattenhoff, CD Cool, CL Bockmeyer, D Cifuentes, D Loffler, DB Badesch, DF Liao, DM Patrick, DP Bartel, E Hergenreider, E Mathe, E Rooij Van, ED Michelakis, FE Wang, G Lagna, G Meister, G Simonneau, G Song, GK Owens, H Beppu, H Kang, H Takahashi, H Tazawa, H Valadi, HY Chiang, J Brennecke, J Kim, J Liu, J Niu, J Ryan, J Sarkar, J Skog, J-S Yang, JD Arroyo, Jennifer S. Grant, JH Newman, JM Boucher, JR Thomson, K Abe, K Rakesh, K Wang, KA O’Donnell, KB Lane, KD Taganov, Kevin White, KN Cowan, KR Cordes, KR Stenmark, KR Stenmark, L Elia, L Guo, L He, L He, L Long, L Tu, LA Brennan, LR Frumkin, M Afrakhte, M Brock, M Das, M Deo, M Humbert, M Humbert, M Humbert, M Izikki, M Rabinovitch, M Trabucchi, M Xin, Margaret R. MacLean, MC Chan, MC Chan, MD Moen, MJ Goumans, MM Hoeper, N Liu, N Raver-Shapira, N Volk, NW Morrell, O Platoshyn, P Caruso, P Fasanaro, P Sklepkiewicz, R Kulshreshtha, R Kumarswamy, R Paulin, RD Machado, RJ Dekker, RM O’Connell, S Bonnet, S Chakravarthy, S Jalali, S Mizuno, S Sakamoto, S Sakao, S Yang, SA Moschos, SS Pullamsetti, T Boettger, T Thum, TC Chang, TX Lu, U Bruning, VN Parikh, W Shi, WB Li, X Huang, X Ji, X Long, X Yang, Y Cheng, Y Cheng, Y Ling, Y Liu, YL Jiang   +137 more
core   +2 more sources

Hypoxia enhances interactions between Na+/H+ exchanger isoform 1 and actin filaments via ezrin in pulmonary vascular smooth muscle

Frontiers in Physiology, 2023
Exposure to hypoxia, due to high altitude or chronic lung disease, leads to structural changes in the pulmonary vascular wall, including hyperplasia and migration of pulmonary arterial smooth muscle cells (PASMCs).
Julie M. Lade, Manuella R. Andrade, Clark Undem, Jasmine Walker, Haiyang Jiang, Xin Yun, Larissa A. Shimoda   +6 more
doaj   +1 more source

Tensin1 expression and function in chronic obstructive pulmonary disease [PDF]

, 2019
open access articleChronic obstructive pulmonary disease (COPD) constitutes a major cause of morbidity and mortality. Genome wide association studies have shown significant associations between airflow obstruction or COPD with a non-synonymous SNP in ...
Amrani, Y., Bradding, Peter, Brightling, C. E., Clark, K., Gooptu, B., Roach, K.M., Smallwood, Dawn T., Stylianou, P.   +7 more
core   +1 more source

Development and Application of a Functional Human Esophageal Mucosa Explant Platform to Eosinophilic Esophagitis. [PDF]

, 2019
There is an increasing prevalence of esophageal diseases but intact human tissue platforms to study esophageal function, disease mechanisms, and the interactions between cell types in situ are lacking.
Aceves, Seema S, Adejumobi, Dolapo, Akuthota, Praveen, Dohil, Ranjan, Duong, Loan D, Jones, Stacie M, Kurten, Richard C, Levy, Rebecca, Newbury, Robert O, Rawson, Renee, Rothenberg, Marc E, Shoda, Tetsuo, Wright, Benjamin L   +12 more
core   +3 more sources

Regulation of human airway smooth muscle cell migration and relevance to asthma

Respiratory Research, 2017
Airway remodelling is an important feature of asthma pathogenesis. A key structural change inherent in airway remodelling is increased airway smooth muscle mass.
Brittany Salter, Cara Pray, Katherine Radford, James G. Martin, Parameswaran Nair   +4 more
doaj   +1 more source

Specialized mouse embryonic stem cells for studying vascular development. [PDF]

, 2014
Vascular progenitor cells are desirable in a variety of therapeutic strategies; however, the lineage commitment of endothelial and smooth muscle cell from a common progenitor is not well-understood.
Burns, Andrew B, Fan, Yuhong, Glaser, Drew E, Hatano, Rachel, McCloskey, Kara E, Medrzycki, Magdalena   +5 more
core   +1 more source

Caveolin-3 promotes a vascular smooth muscle contractile phenotype

Frontiers in Cardiovascular Medicine, 2015
Epidemiological studies have demonstrated the importance of cardiovascular diseases in Western countries. Among the cell types associated with a dysfunctional vasculature, smooth muscle cells are believed to play an essential role in the development of ...
Jorge L. Gutierrez-Pajares, Jeannette eIturrieta, Vipin eDulam, Yu eWang, Yu eWang, Stephanos ePavlides, Gabriella eMalacari, Michael P. Lisanti, Philippe G. Frank   +8 more
doaj   +1 more source

Generation of myogenic progenitor cell-derived smooth muscle cells for sphincter regeneration

Stem Cell Research & Therapy, 2020
Background Degeneration of smooth muscles in sphincters can cause debilitating diseases such as fecal incontinence. Skeletal muscle-derived cells have been effectively used in clinics for the regeneration of the skeletal muscle sphincters, such as the ...
Marco Thurner, Martin Deutsch, Katrin Janke, Franka Messner, Christina Kreutzer, Stanislav Beyl, Sébastien Couillard-Després, Steffen Hering, Jakob Troppmair, Rainer Marksteiner   +9 more
doaj   +1 more source

Ablation of smooth muscle myosin heavy chain SM2 increases smooth muscle contractility and results in postnatal death in mice [PDF]

, 2008
The smooth muscle myosin heavy chains (SMHC) are motor proteins powering smooth muscle contraction. Alternate splicing of SHMC gene at the C-terminus produces SM1, and SM2 myosin isoforms; SM2 (200 kDa) contains a unique 9-amino-acid sequence at the ...
Aikawa, Babij, Babu, Cher, Craig, G. J. Babu, Kelley, Lauzon, Loukianov, M. Chi, M. Periasamy, Miano, Morano, Murphy, Nagai, Nagai, Rovner, Rovner, S. Vedamoorthyrao, SOMLYO, Wang, Y. Zhou, Zhou   +22 more
core   +3 more sources

Masson Trichrome Stain Helps Differentiate Myofibroma from Smooth Muscle Lesions in the Head and Neck Region

Journal of the Formosan Medical Association, 2008
Myofibromas are well described in the head and neck region, but differentiating them from smooth muscle lesions is still difficult using smooth muscle immunohistochemical stains.
Julia Yu Fong Chang, Harvey P. Kessler
doaj   +1 more source