Results 41 to 50 of about 2,833,163 (320)

Smooth Muscle Enriched Long Noncoding RNA (SMILR) Regulates Cell Proliferation

Circulation, 2016
Background— Phenotypic switching of vascular smooth muscle cells from a contractile to a synthetic state is implicated in diverse vascular pathologies, including atherogenesis, plaque stabilization, and neointimal hyperplasia.
M. Ballantyne, Karine Pinel, R. Dakin, A. Vesey, L. Diver, R. Mackenzie, R. García, P. Welsh, N. Sattar, G. Hamilton, N. Joshi, M. Dweck, J. Miano, M. McBride, D. Newby, R. Mcdonald, A. Baker   +16 more
semanticscholar   +1 more source

Vascular Smooth Muscle Cells.

Arteriosclerosis, Thrombosis and Vascular Biology, 2016
Decades of work have shown that vascular smooth muscle cell (SMC) phenotypes are controlled by cues received from the local environment.1–3 When nestled into a cage of cross-linked collagen and elastin of its own making,4 medial SMCs exhibit a fully ...
M. Majesky
semanticscholar   +1 more source

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

Smooth Muscle-Targeted Overexpression of Peroxisome Proliferator Activated Receptor-γ Disrupts Vascular Wall Structure and Function. [PDF]

PLoS ONE, 2015
Activation of the nuclear hormone receptor, PPARγ, with pharmacological agonists promotes a contractile vascular smooth muscle cell phenotype and reduces oxidative stress and cell proliferation, particularly under pathological conditions including ...
Jennifer M Kleinhenz, Tamara C Murphy, Anastassia P Pokutta-Paskaleva, Rudolph L Gleason, Alicia N Lyle, W Robert Taylor, Mitsi A Blount, Juan Cheng, Qinglin Yang, Roy L Sutliff, C Michael Hart   +10 more
doaj   +1 more source

Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.

Journal of Clinical Investigation, 1989
Endothelium-derived relaxing factor has been recently identified as nitric oxide. The purpose of this study was to determine if vasodilator drugs that generate nitric oxide inhibit vascular smooth muscle mitogenesis and proliferation in culture.
U. Garg, A. Hassid
semanticscholar   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

The Myogenic Response in Isolated Rat Cerebrovascular Arteries: Smooth Muscle Cell Model [PDF]

Medical Engineering & Physics, 25(8):691-709, 2003, 2013
Previous models of the cerebrovascular smooth muscle cell have not addressed the interaction between the electrical, chemical and mechanical components of cell function during the development of active tension. These models are primarily electrical, biochemical or mechanical in their orientation, and do not permit a full exploration of how the smooth ...
arxiv   +1 more source

Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells

Nature Cell Biology, 2015
The use of human pluripotent stem cells for in vitro disease modelling and clinical applications requires protocols that convert these cells into relevant adult cell types. Here, we report the rapid and efficient differentiation of human pluripotent stem
Christoph Patsch, Ludivine Challet-Meylan, E. Thoma, E. Urich, Tobias Heckel, J. O’Sullivan, Stephanie Grainger, Friedrich G. Kapp, Lin Sun, K. Christensen, Yulei Xia, Mary H. C. Florido, Wei He, W. Pan, M. Prummer, C. Warren, R. Jakob‐Roetne, U. Certa, R. Jagasia, P. Freskgård, Isaac Adatto, D. Kling, P. Huang, L. Zon, E. Chaikof, Robert E. Gerszten, M. Graf, R. Iacone, Chad A. Cowan   +28 more
semanticscholar   +1 more source

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

The Anatomic Features of Müller’s Muscle: A Histology Study in Chinese

Plastic and Reconstructive Surgery, Global Open, 2021
Background:. The purpose of this article is to clarify the character of Müller’s muscle in Chinese specimens. Methods:. Ten upper eyelids of 10 formalin-fixed Chinese cadavers (9 elderly people, from 68 to 86 years of age; 1 male child, 10 years old ...
Minchen Zhang, BS, Rong Zhou, BS, Jun Wu, PhD, Lulu Chen, PhD, Zijian Ren, PhD, Weicheng Gao, MD   +5 more
doaj   +1 more source