Results 121 to 130 of about 49,437 (364)

Smoothened receptor signaling regulates the developmental shift of GABA polarity in rat somatosensory cortex

Journal of Cell Science, 2020
Sonic hedgehog (Shh) and its patched–smoothened receptor complex control a variety of functions in the developing central nervous system, such as neural cell proliferation and differentiation.
Quentin Delmotte, Mira Hamze, I. Medina, E. Buhler, Jinwei Zhang, Yesser H. Belgacem, C. Porcher   +6 more
semanticscholar   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Smoothened gene alterations in keratocystic odontogenic tumors [PDF]

Head & Face Medicine, 2014
It has been widely demonstrated that the hedgehog pathway is strongly associated with basal cell carcinoma of the skin (NBCCS). To assess potential DNA alterations related to keratocystic odontogenic tumors (KCOTs), we sequenced smoothened (SMO) genes in 12 sporadic KCOTs.Polymerase chain reaction (PCR), capillary electrophoresis and dideoxy chain ...
Li Tie-Jun, Hong Ying-Ying, Qu Jia-Fei, Chen Feng, Zhang Rui, Peng Li-Ying   +5 more
openaire   +3 more sources

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Overexpression of hedgehog signaling is associated with epidermal tumor formation in vitamin D receptor-null mice. [PDF]

, 2011
The vitamin D receptor (VDR) ligand, 1,25 dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), reduces proliferation and enhances differentiation, and thus has been investigated for a role in preventing or treating cancer.
Bikle, Daniel D, Elalieh, Hashem, Elias, Peter M, Teichert, Arnaud E, Welsh, JoEllen   +4 more
core   +3 more sources

CDK7 inhibition suppresses aberrant hedgehog pathway and overcomes resistance to smoothened antagonists

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance There have been FDA-approved anti-hedgehog drugs for treating hedgehog-driven cancers, which act by antagonizing the upstream component smoothened; however, resistance to smoothened inhibitor (SMOi) drugs have been described.
Fang Liu, Wenyan Jiang, Yi Sui, Wei Meng, Linjun Hou, Tiantian Li, Meng Li, Lei Zhang, Jialin Mo, Jiajia Wang, Yang Zhao, Liye Zhang, Jie Ma, Yujie Tang   +13 more
semanticscholar   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Smoothening cone points with Ricci flow [PDF]

Bulletin de la Société mathématique de France, 2015
We consider Ricci flow on a closed surface with cone points. The main result is: given a (nonsmooth) cone metric g_0 over a closed surface there is a smooth Ricci flow g(t) defined for (0,T], with curvature unbounded above, such that g(t) tends to g_0 as t tends to 0. This result means that Ricci flow provides a way for instantaneously smoothening cone
openaire   +3 more sources

The miR-30 microRNA family targets smoothened to regulate hedgehog signalling in zebrafish early muscle development.

PLoS ONE, 2013
The importance of microRNAs in development is now widely accepted. However, identifying the specific targets of individual microRNAs and understanding their biological significance remains a major challenge.
Ami Ketley, Anne Warren, Emily Holmes, Martin Gering, A Aziz Aboobaker, J David Brook   +5 more
doaj   +1 more source

E3 ligase Herc4 regulates Hedgehog signalling through promoting Smoothened degradation

Journal of Molecular Cell Biology, 2019
Hedgehog (Hh) signalling plays conserved roles in controlling embryonic development; its dysregulation causes many diseases including cancers. The G protein-coupled receptor Smoothened (Smo) is the key signal transducer of the Hh pathway, whose ...
Weirong Jiang, Xia Yao, Zhaoliang Shan, Wenting Li, Yuxue Gao, Qing Zhang   +5 more
semanticscholar   +1 more source