Results 271 to 280 of about 18,652 (289)
An oxysterol ligand for Smoothened [PDF]
Nature Chemical Biology, 2012 20(S)-hydroxycholesterol, a naturally occurring oxysterol, activates the Hedgehog signaling pathway by directly binding an allosteric site on Smoothened.
Hayley J. Sharpe, Frederic J. de Sauvage
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The Path to Chemotaxis and Transcription Is Smoothened
Science Signaling, 2012Distinct outputs of Hedgehog signaling arise from different subcellular localization of the signal transducer Smoothened.
Yoko Inès Nozawa +2 more
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Smoothened antagonists for hair inhibition
Bioorganic & Medicinal Chemistry Letters, 2010A series of aminomethylpyrazoles were prepared and evaluated using cell-based Smoothened beta-lactamase reporter assay and Smoothened binding assay. Potent Smoothened antagonists 10k and 10l were found to inhibit hair growth in vivo in the C3H/HeN mouse hair growth model.
Smith Yvonne Dorothy +14 more
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Ripple formation and smoothening on insulating surfaces [PDF]
Journal of Physics: Condensed Matter, 2009 Ion bombardment of insulating surfaces such as Al(2)O(3) and SiO(2) produces ordered patterns of ripples. The ripple wavelength varies with ion energy, incidence angle and substrate temperature. A region of stability is also known to exist for near-normal incidence during Ar(+) ion bombardment, where initially rough surfaces are smoothened. A number of
Hua Zhou, Randall L. Headrick
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Targeting of Smoothened for therapeutic gain
Trends in Pharmacological Sciences, 2014The Smoothened (Smo) receptor is a key transducer of the Hedgehog (Hh) signaling pathway, which plays a critical role in tissue maintenance and repair. Recent studies have highlighted the therapeutic value of Smo antagonists for treating Hh-linked cancers.
Didier Rognan +3 more
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Smoothening of niobium by electropolishing
Journal of Applied Electrochemistry, 2013The effects of various electropolishing (EP) parameters such as duration, applied voltage, working temperature, mechanical prepolishing and acid volume ratio on the EP process, and surface smoothness of high purity niobium (Nb) were systematically investigated using electrochemical technique and optical profilometry. The electropolishing parameters had
N.W. Khun +2 more
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1990
The smoothening process, in the form needed in the construction of Neron models, is presented in Sections 3.1 to 3.4. After we have explained the main assertion, we discuss the technique of blowing-up which is basic for obtaining smoothenings. The actual proof of the existence of smoothenings is carried out in Sections 3.3 and 3.4.
Werner Lütkebohmert +2 more
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The smoothening process, in the form needed in the construction of Neron models, is presented in Sections 3.1 to 3.4. After we have explained the main assertion, we discuss the technique of blowing-up which is basic for obtaining smoothenings. The actual proof of the existence of smoothenings is carried out in Sections 3.3 and 3.4.
Werner Lütkebohmert +2 more
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The Role of Smoothened and Hh Signaling in Neovascularization [PDF]
, 2014 New vessel formation plays a key role not only in physiological processes such as embryonic development and wound repair but also during several pathological situations. In this respect, favoringneovascularization represents a promising therapeutic approach that would allow inducing tissue repair.
Soleti, Raffaella +2 more
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Overcoming the resistance mechanisms of Smoothened inhibitors
Drug Discovery Today, 2018Smoothened (Smo), the main transducer of the Hedgehog (Hh) signaling pathway, is a promising target for anticancer therapy. Although vismodegib and sonidegib have demonstrated effectiveness for the treatment of basal cell carcinoma (BCC), their clinical use has been associated with mutation-related drug resistance.
Chenglin Wang +3 more
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Smoothened Inhibitors in Cancer
2015Smoothened (Smo) inhibitors are under intense development for the treatment of cancers linked to abnormal Hedgehog (Hh) signaling. The first inhibitor (vismodegib) was introduced in clinics for basal cell carcinoma and medulloblastomas associated with activating mutations of Hh signaling. In contrast, disappointing data are reported for cancers related
Lucile Hoch, Martial Ruat
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