Results 281 to 289 of about 18,652 (289)

A Partner for Smoothened in Cilia

Science Signaling, 2012
A protein implicated in inherited ciliopathies recruits Smoothened to a ciliary microdomain and is required for Hedgehog signaling.
openaire   +2 more sources

Vertebrate Smoothened functions at the primary cilium

Nature, 2005
The unanticipated involvement of several intraflagellar transport proteins in the mammalian Hedgehog (Hh) pathway has hinted at a functional connection between cilia and Hh signal transduction. Here we show that mammalian Smoothened (Smo), a seven-transmembrane protein essential for Hh signalling, is expressed on the primary cilium.
Jeremy F. Reiter, Pia Aanstad, Kevin C. Corbit, Didier Y.R. Stainier, Andrew R. Norman, Veena Singla   +5 more
openaire   +3 more sources

Regulation of the oncoprotein Smoothened by small molecules

Nature Chemical Biology, 2015
The Hedgehog pathway is critical for animal development and has been implicated in multiple human malignancies. Despite great interest in targeting the pathway pharmacologically, many of the principles underlying the signal transduction cascade remain poorly understood.
Hayley J. Sharpe, Rami N. Hannoush, Weiru Wang, Frederic J. de Sauvage   +3 more
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Resource smoothening in repetitive projects

Computers & Industrial Engineering, 1998
Abstract To manage construction projects properly, it is necessary to establish a project plan for resources utilization. This management function, usually, is carried out in two steps: resource allocation and resource usage smoothening. In this paper, a linear programming model for a single resource allocation and smoothening in repetitive ...
I. E. Korish, M. Aly Barakat, S. M. Hafez, M. H. Elwany   +3 more
openaire   +2 more sources

Quantum smoothening of `classical anomaly' [PDF]

Letters in Mathematical Physics, 1997
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
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Smoothening of thin film surfaces

Proceedings KORUS 2000. The 4th Korea-Russia International Symposium On Science and Technology, 2002
Surface morphologies of thin dielectric films are studied with atomic force microscopy. It is shown that the deposition temperature greatly affects the structure and the surface roughness of the films. Films deposited at room temperature are found to be amorphous and smooth. Films grown at 200/spl deg/C are amorphous, but also contain single inclusions
A. Panin, A. Shugurov
openaire   +2 more sources

Distribution of Smoothened at hippocampal mossy fiber synapses

NeuroReport, 2007
The seven-transmembrane receptor Smoothened is essential for hedgehog signal transduction. In adulthood, the highest density of Smoothened mRNA is found in the granule cell layer of the dentate gyrus. There, Smoothened expression is regulated by the synaptic activity involving the glutamatergic transmission.
Masdeu, Christelle, Bernard, Véronique, Faure, Hélène, Traiffort, Elisabeth, Ruat, Martial   +4 more
openaire   +3 more sources

[Structure of the Smoothened receptor].

Medecine sciences : M/S, 2014
The Smoothened (Smo) receptor is a major component involved in signal transduction of the Hedgehog (Hh) morphogens both during embryogenesis and in the adult. Smo antagonists represent a promi-sing alternative for the treatment of cancers linked to abnormal Hh signalling.
Martial, Ruat, Lucile, Hoch, Hélène, Faure, Didier, Rognan   +3 more
openaire   +1 more source

ACTIVATION OF SMOOTHENED IN THE MURINE UTERUS

Biology of Reproduction, 2007
Jae Wook Jeong, Sophia Y. Tsai, John P. Lydon, Heather L. Franco, Francesco J. DeMayo, Kevin Lee, Lisa D. White   +6 more
openaire   +2 more sources