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Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling [PDF]

Nature Communications, 2013
Smoothened (Smo) is a member of the Frizzled (FzD) class of G-protein-coupled receptors (GPCRs), and functions as the key transducer in the Hedgehog (Hh) signalling pathway.
Ho-Jin Lee, Suresh Marada, Stacey K Ogden   +2 more
exaly   +3 more sources

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Structure of the human smoothened receptor bound to an antitumour agent

Nature, 2013
Huixian Wu, Vsevolod Katritch, Gye Won Han   +2 more
exaly  

Smoothened stimulation by membrane sterols drives Hedgehog pathway activity

Nature, 2019
Ishan Deshpande, Yunxiao Zhang, Betty Ha
exaly  

Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I

Nature, 2004
Jianhang Jia, Chao Tong, Bing Wang
exaly  

The mechanisms of Hedgehog signalling and its roles in development and disease

Nature Reviews Molecular Cell Biology, 2013
James Briscoe
exaly  

Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors

Cancers, 2016
Michael Chan, Hui-Wen Lo, Richard L Carpenter   +2 more
exaly  

Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling

Nature Chemical Biology, 2020
Xiaofeng Qi, Lucas Friedberg, Tao Long
exaly  

Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma

Science Translational Medicine, 2010
Silvia Buonamici, John E Monahan, Xu Wu
exaly  

Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs

Nature Communications, 2014
Huixian Wu, Gye Won Han, Xi-Ping Huang
exaly  

Vertebrate Smoothened functions at the primary cilium

Nature, 2005
Pia Aanstad, Didier Y R Stainier, Jeremy F Reiter   +2 more
exaly