Pharmacological targeting of smoothened receptor cysteine-rich domain by Budesonide promotes in vitro myelination [PDF]
Frontiers in Molecular NeuroscienceBackgroundThe myelin sheath ensures efficient nerve impulse transmission along the axons. Remyelination is a spontaneous process that restores axonal insulation, promoting neuroprotection and recovery after myelin damage.
Antonella Damiana Recchia +12 more
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Sonic hedgehog signaling by the Patched–Smoothened receptor complex [PDF]
Current Biology, 1999 The Hedgehog (Hh) family of secreted proteins is involved in a number of developmental processes as well as in cancer. Genetic and biochemical data suggest that the Sonic hedgehog (Shh) receptor is composed of at least two proteins: the tumor suppressor protein Patched (Ptc) and the seven-transmembrane protein Smoothened (Smo).Using a biochemical assay
Frédéric De Sauvage +2 more
exaly +3 more sources
A structurally guided dissection-then-evolution strategy for ligand optimization of smoothened receptor. [PDF]
Medchemcomm, 2017 We present herein a novel dissection-then-evolution strategy for ligand optimization.
Ye L +12 more
europepmc +4 more sources
Regulation of Smoothened by Drosophila G-protein-coupled receptor kinases
Developmental Biology, 2010 The Hedgehog (Hh) signaling pathway plays a conserved and essential role in regulating development and homeostasis of numerous tissues. Cytoplasmic signaling is initiated by Smoothened (Smo), a G-protein-coupled receptor (GPCR) family member, whose levels and activity are regulated by the Hh receptor Patched (Ptc). In response to Hh binding to Ptc, Ptc-
David Hipfner
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Effect of the sonic hedgehog receptor smoothened on the survival and function of dopaminergic neurons [PDF]
Experimental Neurology, 2016 To determine the influence of the sonic hedgehog (shh) pathway and its receptor smoothened (smo), on the survival and functionality of dopaminergic (DA) neurons.During early development, shh induces the differentiation of DA neurons. However, it is unknown whether shh signaling is required in the maturation or maintenance of DA neurons during later ...
Barry Hoffer, Yu Luo, Jonathan Pace
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Stability study of the human G-protein coupled receptor, Smoothened
Biochimica Et Biophysica Acta - Biomembranes, 2010 Smoothened is a member of the G-protein coupled receptor (GPCR) family responsible for the transduction of the Hedgehog signal to the intracellular effectors of the Hedgehog signaling pathway. Aberrant regulation of this receptor is implicated in many cancers but also in neurodegenerative disorders.
Isabelle Mus-Veteau +2 more
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Smoothened Signaling in Vertebrates Is Facilitated by a G Protein-coupled Receptor Kinase [PDF]
Molecular Biology of the Cell, 2008 Smoothened, a heptahelical membrane protein, functions as the transducer of Hedgehog signaling. The kinases that modulate Smoothened have been thoroughly analyzed in flies. However, little is known about how phosphorylation affects Smoothened in vertebrates, mainly, because the residues, where Smoothened is phosphorylated are not conserved from ...
Lawrence Barak +2 more
exaly +4 more sources
Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling
eLife, 2016 Cholesterol is necessary for the function of many G-protein coupled receptors (GPCRs). We find that cholesterol is not just necessary but also sufficient to activate signaling by the Hedgehog (Hh) pathway, a prominent cell-cell communication system in ...
Giovanni Luchetti +8 more
doaj +4 more sources
Hedgehog signalling controls sinoatrial node development and atrioventricular cushion formation
Open Biology, 2021 Smoothened is a key receptor of the hedgehog pathway, but the roles of Smoothened in cardiac development remain incompletely understood. In this study, we found that the conditional knockout of Smoothened from the mesoderm impaired the development of the
Chaohui Zhang +14 more
doaj +1 more source
Identification of Novel Smoothened Ligands Using Structure-Based Docking. [PDF]
PLoS ONE, 2016 The seven transmembrane protein Smoothened is required for Hedgehog signaling during embryonic development and adult tissue homeostasis. Inappropriate activation of the Hedgehog signalling pathway leads to cancers such as basal cell carcinoma and ...
Celine Lacroix +6 more
doaj +1 more source