Results 21 to 30 of about 12,144 (240)

Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes

eLife, 2021
A long-standing mystery in vertebrate Hedgehog signaling is how Patched 1 (PTCH1), the receptor for Hedgehog ligands, inhibits the activity of Smoothened, the protein that transmits the signal across the membrane. We previously proposed (Kinnebrew et al.,
Maia Kinnebrew, Giovanni Luchetti, Ria Sircar, Sara Frigui, Lucrezia Vittoria Viti, Tomoki Naito, Francis Beckert, Yasunori Saheki, Christian Siebold, Arun Radhakrishnan, Rajat Rohatgi   +10 more
doaj   +1 more source

In silico studies on smoothened human receptor and its antagonists in search of anticancer effects [PDF]

Journal of the Serbian Chemical Society, 2020
Lately, the cancers related with abnormal hedgehog (Hh) signalling pathway are targeted by smoothened (SMO) receptor inhibitors that are rapidly developing.
Borota Ana, Avram Sorin, Curpan Ramona, Bora Alina, Varga Daniela, Halip Liliana, Crisan Luminita   +6 more
doaj   +1 more source

Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation. [PDF]

PLoS ONE, 2016
The seven-transmembrane receptor Smoothened (Smo) activates all Hedgehog (Hh) signaling by translocation into the primary cilia (PC), but how this is regulated is not well understood.
Bomi Jung, Daniela Padula, Ingo Burtscher, Cedric Landerer, Dominik Lutter, Fabian Theis, Ana C Messias, Arie Geerlof, Michael Sattler, Elisabeth Kremmer, Karsten Boldt, Marius Ueffing, Heiko Lickert   +12 more
doaj   +1 more source

Smoothened receptor signaling regulates the developmental shift of GABA polarity in rat somatosensory cortex. [PDF]

J Cell Sci, 2020
ABSTRACT Sonic Hedgehog (Shh) and its patched-smoothened receptor complex control a variety of functions in the developing central nervous system (CNS) such as neural cell proliferation and differentiation. Recently, Shh signaling components have been found to be expressed at the synaptic level in the postnatal brain,
Delmotte Q, Hamze M, Medina I, Buhler E, Zhang J, Belgacem YH, Porcher C.   +6 more
europepmc   +5 more sources

A broadly conserved g-protein-coupled receptor kinase phosphorylation mechanism controls Drosophila smoothened activity. [PDF]

PLoS Genetics, 2014
Hedgehog (Hh) signaling is essential for normal growth, patterning, and homeostasis of many tissues in diverse organisms, and is misregulated in a variety of diseases including cancer.
Dominic Maier, Shuofei Cheng, Denis Faubert, David R Hipfner   +3 more
doaj   +1 more source

Sonic hedgehog pathway for the treatment of inflammatory diseases: implications and opportunities for future research

Journal for ImmunoTherapy of Cancer, 2022
The Sonic hedgehog (Shh) signaling pathway is an essential pathway in the human body that plays an important role in embryogenesis and tissue homeostasis.
Paolo Antonio Ascierto, Marco Palla, Luigi Scarpato, Rossella Di Trolio   +3 more
doaj   +1 more source

CFP1 governs uterine epigenetic landscapes to intervene in progesterone responses for uterine physiology and suppression of endometriosis

Nature Communications, 2023
Progesterone (P4) is required for the preparation of the endometrium for a successful pregnancy. P4 resistance is a leading cause of the pathogenesis of endometrial disorders like endometriosis, often leading to infertility; however, the underlying ...
Seung Chel Yang, Mira Park, Kwon-Ho Hong, Hyeonwoo La, Chanhyeok Park, Peike Wang, Gaizhen Li, Qionghua Chen, Youngsok Choi, Francesco J. DeMayo, John P. Lydon, David G. Skalnik, Hyunjung J. Lim, Seok-Ho Hong, So Hee Park, Yeon Sun Kim, Hye-Ryun Kim, Haengseok Song   +17 more
doaj   +1 more source

A Smoothened receptor agonist is neuroprotective and promotes regeneration after ischemic brain injury. [PDF]

Cell Death Dis, 2014
AbstractIschemic stroke occurs as a result of blood supply interruption to the brain causing tissue degeneration, patient disabilities or death. Currently, treatment of ischemic stroke is limited to thrombolytic therapy with a narrow time window of administration.
Chechneva OV, Mayrhofer F, Daugherty DJ, Krishnamurty RG, Bannerman P, Pleasure DE, Deng W.   +6 more
europepmc   +6 more sources

Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. [PDF]

PLoS ONE, 2009
Activation of Hedgehog (Hh) signaling requires the transmembrane protein Smoothened (Smo), a member of the G-protein coupled receptor superfamily. In mammals, Smo translocates to the primary cilium upon binding of Hh ligands to their receptor, Patched ...
Christopher W Wilson, Miao-Hsueh Chen, Pao-Tien Chuang   +2 more
doaj   +1 more source

Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover.

PLoS Biology, 2013
Hedgehog signaling plays conserved roles in controlling embryonic development; its dysregulation has been implicated in many human diseases including cancers.
Shoujun Huang, Zhao Zhang, Chunxia Zhang, Xiangdong Lv, Xiudeng Zheng, Zhenping Chen, Liwei Sun, Hailong Wang, Yuanxiang Zhu, Jing Zhang, Shuyan Yang, Yi Lu, Qinmiao Sun, Yi Tao, Feng Liu, Yun Zhao, Dahua Chen   +16 more
doaj   +1 more source