Results 21 to 30 of about 2,656,785 (305)
Diphenolic Acid in Plastics Activates Smoothened Receptor
The FASEB Journal, 2016 Kirti Kandhwal +3 more
semanticscholar +2 more sources
Hedgehog signalling controls sinoatrial node development and atrioventricular cushion formation
Open Biology, 2021 Smoothened is a key receptor of the hedgehog pathway, but the roles of Smoothened in cardiac development remain incompletely understood. In this study, we found that the conditional knockout of Smoothened from the mesoderm impaired the development of the
Chaohui Zhang +14 more
doaj +1 more source
Identification of Novel Smoothened Ligands Using Structure-Based Docking. [PDF]
PLoS ONE, 2016 The seven transmembrane protein Smoothened is required for Hedgehog signaling during embryonic development and adult tissue homeostasis. Inappropriate activation of the Hedgehog signalling pathway leads to cancers such as basal cell carcinoma and ...
Celine Lacroix +6 more
doaj +1 more source
Chemistry, 2023 Natural products (NPs) are highly profitable pharmacological tools due to their chemical diversity and ability to modulate biological systems. Accessing new chemical entities while retaining the biological relevance of natural chemotypes is a fundamental
D. Quaglio +10 more
semanticscholar +1 more source
The hedgehog receptor patched is involved in cholesterol transport. [PDF]
PLoS ONE, 2011 Sonic hedgehog (Shh) signaling plays a crucial role in growth and patterning during embryonic development, and also in stem cell maintenance and tissue regeneration in adults. Aberrant Shh pathway activation is involved in the development of many tumors,
Michel Bidet +10 more
doaj +1 more source
Solubilization, purification, and ligand binding characterization of G protein-coupled receptor SMO in native membrane bilayer using styrene maleic acid copolymer [PDF]
PeerJ, 2022 Smoothened (SMO) protein is a member of the G protein-coupled receptor (GPCR) family that is involved in the Hedgehog (Hh) signaling pathway. It is a putative target for treating various cancers, including medulloblastoma and basal cell carcinoma (BCC ...
Lina Zhu +10 more
doaj +2 more sources
Sonic hedgehog signaling by the Patched–Smoothened receptor complex [PDF]
Current Biology, 1999 The Hedgehog (Hh) family of secreted proteins is involved in a number of developmental processes as well as in cancer. Genetic and biochemical data suggest that the Sonic hedgehog (Shh) receptor is composed of at least two proteins: the tumor suppressor protein Patched (Ptc) and the seven-transmembrane protein Smoothened (Smo).Using a biochemical assay
Murone, Maximilien +2 more
openaire +2 more sources
Residue 6.43 defines receptor function in class F GPCRs
Nature Communications, 2021 The class Frizzled of G protein-coupled receptors (GPCRs) consist of ten Frizzled (FZD1-10) subtypes and Smoothened (SMO). Here the Schulte laboratory demonstrates that FZDs differ substantially from SMO in receptor activation-associated conformational ...
Ainoleena Turku +4 more
doaj +1 more source
Role of the Drosophila non-visual ß-arrestin kurtz in hedgehog signalling. [PDF]
PLoS Genetics, 2011 The non-visual ß-arrestins are cytosolic proteins highly conserved across species that participate in a variety of signalling events, including plasma membrane receptor degradation, recycling, and signalling, and that can also act as scaffolding for ...
Cristina Molnar +5 more
doaj +1 more source