Results 31 to 40 of about 12,161 (240)
Nature Communications, 2023 Progesterone (P4) is required for the preparation of the endometrium for a successful pregnancy. P4 resistance is a leading cause of the pathogenesis of endometrial disorders like endometriosis, often leading to infertility; however, the underlying ...
Seung Chel Yang +17 more
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Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. [PDF]
PLoS ONE, 2009 Activation of Hedgehog (Hh) signaling requires the transmembrane protein Smoothened (Smo), a member of the G-protein coupled receptor superfamily. In mammals, Smo translocates to the primary cilium upon binding of Hh ligands to their receptor, Patched ...
Christopher W Wilson +2 more
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PLoS Biology, 2013 Hedgehog signaling plays conserved roles in controlling embryonic development; its dysregulation has been implicated in many human diseases including cancers.
Shoujun Huang +16 more
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PLoS ONE, 2013 The importance of microRNAs in development is now widely accepted. However, identifying the specific targets of individual microRNAs and understanding their biological significance remains a major challenge.
Ami Ketley +5 more
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Sonic Hedgehog activation is implicated in diosgenin-induced megakaryocytic differentiation of human erythroleukemia cells. [PDF]
PLoS ONE, 2014 Differentiation therapy is a means to treat cancer and is induced by different agents with low toxicity and more specificity than traditional ones. Diosgenin, a plant steroid, is able to induce megakaryocytic differentiation or apoptosis in human HEL ...
Lamia Ghezali +4 more
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Frontiers in Cell and Developmental Biology, 2021 G protein-coupled receptors (GPCRs) are the largest family of membrane receptors in animals and humans, which transmit various signals from the extracellular environment into cells.
Yan-Li Li +7 more
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Drug Delivery Systems for Hedgehog Inhibitors in the Treatment of SHH-Medulloblastoma
Frontiers in Chemistry, 2021 Medulloblastoma (MB) is a highly aggressive pediatric tumor of the cerebellum. Hyperactivation of the Hedgehog (HH) pathway is observed in about 30% of all MB diagnoses, thereby bringing out its pharmacological blockade as a promising therapeutic ...
Miriam Caimano +5 more
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Cholesterol and Hedgehog Signaling: Mutual Regulation and Beyond
Frontiers in Cell and Developmental Biology, 2022 The Hedgehog (HH) signaling is one of the key agents that govern the precisely regulated developmental processes of multicellular organisms in vertebrates and invertebrates.
Shouying Xu, Chao Tang
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Hedgehog Signaling Regulates the Ciliary Transport of Odorant Receptors in Drosophila
Cell Reports, 2016 Hedgehog (Hh) signaling is a key regulatory pathway during development and also has a functional role in mature neurons. Here, we show that Hh signaling regulates the odor response in adult Drosophila olfactory sensory neurons (OSNs). We demonstrate that
Gonzalo M. Sanchez +7 more
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Nature Communications, 2023 The class Frizzled of G protein-coupled receptors (GPCRs), consisting of ten Frizzled (FZD1-10) paralogs and Smoothened, remains one of the most enigmatic GPCR families.
Lukas Grätz +8 more
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