Results 31 to 40 of about 12,144 (240)
Sonic Hedgehog activation is implicated in diosgenin-induced megakaryocytic differentiation of human erythroleukemia cells. [PDF]
PLoS ONE, 2014 Differentiation therapy is a means to treat cancer and is induced by different agents with low toxicity and more specificity than traditional ones. Diosgenin, a plant steroid, is able to induce megakaryocytic differentiation or apoptosis in human HEL ...
Lamia Ghezali +4 more
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PLoS ONE, 2013 The importance of microRNAs in development is now widely accepted. However, identifying the specific targets of individual microRNAs and understanding their biological significance remains a major challenge.
Ami Ketley +5 more
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Frontiers in Cell and Developmental Biology, 2021 G protein-coupled receptors (GPCRs) are the largest family of membrane receptors in animals and humans, which transmit various signals from the extracellular environment into cells.
Yan-Li Li +7 more
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Smoothened Signaling in Vertebrates Is Facilitated by a G Protein-coupled Receptor Kinase [PDF]
Molecular Biology of the Cell, 2008 Smoothened, a heptahelical membrane protein, functions as the transducer of Hedgehog signaling. The kinases that modulate Smoothened have been thoroughly analyzed in flies. However, little is known about how phosphorylation affects Smoothened in vertebrates, mainly, because the residues, where Smoothened is phosphorylated are not conserved from ...
Philipp, Melanie +6 more
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Drug Delivery Systems for Hedgehog Inhibitors in the Treatment of SHH-Medulloblastoma
Frontiers in Chemistry, 2021 Medulloblastoma (MB) is a highly aggressive pediatric tumor of the cerebellum. Hyperactivation of the Hedgehog (HH) pathway is observed in about 30% of all MB diagnoses, thereby bringing out its pharmacological blockade as a promising therapeutic ...
Miriam Caimano +5 more
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Cholesterol and Hedgehog Signaling: Mutual Regulation and Beyond
Frontiers in Cell and Developmental Biology, 2022 The Hedgehog (HH) signaling is one of the key agents that govern the precisely regulated developmental processes of multicellular organisms in vertebrates and invertebrates.
Shouying Xu, Chao Tang
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Hedgehog Signaling Regulates the Ciliary Transport of Odorant Receptors in Drosophila
Cell Reports, 2016 Hedgehog (Hh) signaling is a key regulatory pathway during development and also has a functional role in mature neurons. Here, we show that Hh signaling regulates the odor response in adult Drosophila olfactory sensory neurons (OSNs). We demonstrate that
Gonzalo M. Sanchez +7 more
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Nature Communications, 2023 The class Frizzled of G protein-coupled receptors (GPCRs), consisting of ten Frizzled (FZD1-10) paralogs and Smoothened, remains one of the most enigmatic GPCR families.
Lukas Grätz +8 more
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Smoothened (SMO) receptor mutations dictate resistance to vismodegib in basal cell carcinoma [PDF]
Molecular Oncology, 2014 Abstract Basal cell carcinomas (BCCs) and a subset of medulloblastomas are characterized by loss‐of‐function mutations in the tumor suppressor gene, PTCH1. PTCH1 normally functions by repressing the activity of the Smoothened (SMO) receptor.
PRICL, SABRINA +9 more
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PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail. [PDF]
PLoS Biology, 2016 In Hedgehog (Hh) signaling, binding of Hh to the Patched-Interference Hh (Ptc-Ihog) receptor complex relieves Ptc inhibition on Smoothened (Smo). A longstanding question is how Ptc inhibits Smo and how such inhibition is relieved by Hh stimulation.
Kai Jiang +7 more
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