Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes
eLife, 2021 A long-standing mystery in vertebrate Hedgehog signaling is how Patched 1 (PTCH1), the receptor for Hedgehog ligands, inhibits the activity of Smoothened, the protein that transmits the signal across the membrane. We previously proposed (Kinnebrew et al.,
Maia Kinnebrew +10 more
doaj +1 more source
In silico studies on smoothened human receptor and its antagonists in search of anticancer effects [PDF]
Journal of the Serbian Chemical Society, 2020 Lately, the cancers related with abnormal hedgehog (Hh) signalling pathway are targeted by smoothened (SMO) receptor inhibitors that are rapidly developing.
Borota Ana +6 more
doaj +1 more source
Smoothened (SMO) receptor mutations dictate resistance to vismodegib in basal cell carcinoma [PDF]
Molecular Oncology, 2014 Abstract Basal cell carcinomas (BCCs) and a subset of medulloblastomas are characterized by loss‐of‐function mutations in the tumor suppressor gene, PTCH1. PTCH1 normally functions by repressing the activity of the Smoothened (SMO) receptor.
PRICL, SABRINA +9 more
openaire +4 more sources
Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation. [PDF]
PLoS ONE, 2016 The seven-transmembrane receptor Smoothened (Smo) activates all Hedgehog (Hh) signaling by translocation into the primary cilia (PC), but how this is regulated is not well understood.
Bomi Jung +12 more
doaj +1 more source
A broadly conserved g-protein-coupled receptor kinase phosphorylation mechanism controls Drosophila smoothened activity. [PDF]
PLoS Genetics, 2014 Hedgehog (Hh) signaling is essential for normal growth, patterning, and homeostasis of many tissues in diverse organisms, and is misregulated in a variety of diseases including cancer.
Dominic Maier +3 more
doaj +1 more source
Journal for ImmunoTherapy of Cancer, 2022 The Sonic hedgehog (Shh) signaling pathway is an essential pathway in the human body that plays an important role in embryogenesis and tissue homeostasis.
Paolo Antonio Ascierto +3 more
doaj +1 more source
Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling. [PDF]
, 2013 Smoothened (Smo) is a member of the Frizzled (FzD) class of G-protein-coupled receptors (GPCRs), and functions as the key transducer in the Hedgehog (Hh) signalling pathway.
Bao, Ju +8 more
core +1 more source
Hedgehog signaling pathway and its targets for treatment in basal cell carcinoma [PDF]
, 2012 Basal cell carcinoma (BCC) of the skin is the most common type of cancer, and accounts for up to 40% of all cancers in the United States with a growing incidence rate in the last decades in all developed countries.
CUCCHI, DANILO +3 more
core +3 more sources
The Many Hats of Sonic Hedgehog Signaling in Nervous System Development and Disease. [PDF]
, 2016 Sonic hedgehog (Shh) signaling occurs concurrently with the many processes that constitute nervous system development. Although Shh is mostly known for its proliferative and morphogenic action through its effects on neural stem cells and progenitors, it ...
Belgacem, Yesser H +4 more
core +5 more sources
Nature Communications, 2023 Progesterone (P4) is required for the preparation of the endometrium for a successful pregnancy. P4 resistance is a leading cause of the pathogenesis of endometrial disorders like endometriosis, often leading to infertility; however, the underlying ...
Seung Chel Yang +17 more
doaj +1 more source