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Genetic Alterations of SMYD4 in Solid Tumors Using Integrative Multi-Platform Analysis. [PDF]
Int J Mol SciOlivera Santana BL +3 more
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Smyd3-associated regulatory pathways in cancer
Seminars in Cancer Biology, 2017SMYD3 is a member of the SET and MYND-domain family of methyl-transferases, the increased expression of which correlates with poor prognosis in various types of cancer. In liver and colon tumors, SMYD3 is localized in the nucleus, where it interacts with RNA Pol II and H3K4me3 and functions as a selective transcriptional amplifier of oncogenes and ...
Pantelis Hatzis +2 more
exaly +3 more sources
Histone methyltransferase Smyd3 is a new regulator for vascular senescence [PDF]
Aging Cell, 2020 AbstractEndothelial cell senescence is one of the main risk factors contributing to vascular diseases. As increasing number of “epigenetic drugs” entering clinical trials, understanding the mechanism of epigenetic regulation in vascular aging has significant implications in finding targets to cure vascular diseases.
Ting Ni, Yi Zhun Zhu, Xiao-Li Tian
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SMYD3: An Oncogenic Driver Targeting Epigenetic Regulation and Signaling Pathways [PDF]
Cancers, 2020 SMYD3 is a member of the SMYD lysine methylase family and plays an important role in the methylation of various histone and non-histone targets. Aberrant SMYD3 expression contributes to carcinogenesis and SMYD3 upregulation was proposed as a prognostic marker in various solid cancers.
Giuseppina Caretti +2 more
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The role of NeuroD1 in the upregulation of SMYD3 by HBx.
Journal of Clinical Oncology, 2012183 Background: SET and MYND Domain-Containing Protein 3 (SMYD3) is frequently overexpressed in hepatocellular carcinoma (HCC) exhibiting increased malignant phenotypes. It has also been known that the hepatitis B virus x protein (HBx) is strongly associated with HCC development and progression.
Junyao Xu +3 more
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Overexpression of SMYD3 was associated with increased STAT3 activation in gastric cancer
Medical Oncology, 2014This study aimed to investigate mRNA and protein expressions of SET and MYND domain-containing protein 3 (SMYD3), STAT3, and phosphorylated STAT3 (pSTAT3) in gastric cancer (GC). This study was also conducted to explore the correlations between these proteins and biological behaviors of GC.
Han Liang, Xue-Gang Luo, Jingyu Deng
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Overexpression of the SMYD3 Promotes Proliferation, Migration, and Invasion of Pancreatic Cancer
Digestive Diseases and Sciences, 2019The Suvar, Enhancer of zeste, and Trithorax (SET), myeloid-Nervy-DEAF-1 (MYND) domain-containing protein 3 (SMYD3), was reported to be upregulated in various tumors. However, its role in pancreatic cancer progression remains unclear.To explore the role of SMYD3 in the pancreatic cancer.The expressions of SMYD3, caspase-3, and matrix metallopeptidase-2 (
Cheng-Lin, Zhu, Qiang, Huang
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