Results 131 to 140 of about 2,026 (156)
Some of the next articles are maybe not open access.
SMYD3-NY, a novel SMYD3 mRNA transcript variant, may have a role in human spermatogenesis.
Annals of clinical and laboratory science, 2006Identification of genes specifically expressed in adult and fetal testis is important to further our understanding of testis development and function. In this study, a novel SMYD3 transcript variant, termed SMYD3-NY (GenBank Accession No. AY186742), was identified by hybridization of adult and fetal human testis cDNA probes with a human cDNA microarray.
Zuomin, Zhou +7 more
openaire +1 more source
Determining the Roles of Smyd3 and Wdr74 In Vivo
2011Preimplantation is a short yet critical time period for the embryo that includes dramatic changes in gene expression and developmental potential. During early cleavage, a combination of maternal and zygotic factors program the embryonic genome. These dynamic events result in critical differentiation steps including the first lineage specification (ICM ...
openaire +2 more sources
SMYD3 promoter Hypomethylation is Associated with the Risk of Colorectal Cancer
Future Oncology, 2018SMYD3 encodes histone lysine methyltransferase. The goal of our study was to investigate the association between SMYD3 methylation and colorectal cancer (CRC).SMYD3 methylation was measured by quantitative methylation-specific PCR method in 117 pairs of CRC tumor and para-tumor tissues.Significantly lower SMYD3 methylation was observed in CRC tumor ...
Bin, Li +11 more
openaire +2 more sources
SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells
Nature Cell Biology, 2004Colorectal and hepatocellular carcinomas are some of the leading causes of cancer deaths worldwide, but the mechanisms that underly these malignancies are not fully understood. Here we report the identification of SMYD3, a gene that is over-expressed in the majority of colorectal carcinomas and hepatocellular carcinomas.
Ryuji, Hamamoto +7 more
openaire +2 more sources
Journal of Molecular Biology, 2011
The SmyD family represents a new class of chromatin regulators that is important in heart and skeletal muscle development. However, the critical questions regarding how they are regulated posttranslationally remain largely unknown. We previously suggested that the histone methyltransferase activity of SmyD1, a vital myogenic regulator, appears to be ...
Nualpun, Sirinupong +3 more
openaire +2 more sources
The SmyD family represents a new class of chromatin regulators that is important in heart and skeletal muscle development. However, the critical questions regarding how they are regulated posttranslationally remain largely unknown. We previously suggested that the histone methyltransferase activity of SmyD1, a vital myogenic regulator, appears to be ...
Nualpun, Sirinupong +3 more
openaire +2 more sources
Small-molecule Inhibitors of Lysine Methyltransferases SMYD2 and SMYD3: Current Trends
Future Medicinal Chemistry, 2019Lysine methyltransferases SMYD2 and SMYD3 are involved in the epigenetic regulation of cell differentiation and functioning. Overexpression and deregulation of these enzymes have been correlated to the insurgence and progression of different tumors, making them promising molecular targets in cancer therapy even if their role in tumors is not yet fully ...
Fabini E. +4 more
openaire +2 more sources