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SMYD3-NY, a novel SMYD3 mRNA transcript variant, may have a role in human spermatogenesis.
Annals of clinical and laboratory science, 2006Identification of genes specifically expressed in adult and fetal testis is important to further our understanding of testis development and function. In this study, a novel SMYD3 transcript variant, termed SMYD3-NY (GenBank Accession No. AY186742), was identified by hybridization of adult and fetal human testis cDNA probes with a human cDNA microarray.
Zuomin, Zhou +7 more
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Determining the Roles of Smyd3 and Wdr74 In Vivo
2011Preimplantation is a short yet critical time period for the embryo that includes dramatic changes in gene expression and developmental potential. During early cleavage, a combination of maternal and zygotic factors program the embryonic genome. These dynamic events result in critical differentiation steps including the first lineage specification (ICM ...
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Simultaneous expression of SMYD3 and EGFP in NIH3T3 cells
2010 International Conference on Bioinformatics and Biomedical Technology, 2010SET and MYND domain-containing protein 3 (SMYD3) is a novel histone methyltransferase involved in human carcinogenesis. To establish the transgenic cell model of SMYD3 for the further studies on the characteristics and functions of SMYD3, in the present study, the human SMYD3 gene was subcloned into pIRES2-EGFP eukaryotic expressing vector.
null Xue-Gang Luo +4 more
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SMYD3 promoter Hypomethylation is Associated with the Risk of Colorectal Cancer
Future Oncology, 2018SMYD3 encodes histone lysine methyltransferase. The goal of our study was to investigate the association between SMYD3 methylation and colorectal cancer (CRC).SMYD3 methylation was measured by quantitative methylation-specific PCR method in 117 pairs of CRC tumor and para-tumor tissues.Significantly lower SMYD3 methylation was observed in CRC tumor ...
Bin, Li +11 more
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SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells
Nature Cell Biology, 2004Colorectal and hepatocellular carcinomas are some of the leading causes of cancer deaths worldwide, but the mechanisms that underly these malignancies are not fully understood. Here we report the identification of SMYD3, a gene that is over-expressed in the majority of colorectal carcinomas and hepatocellular carcinomas.
Ryuji, Hamamoto +7 more
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