SMYD3 Promotes Immune Evasion in Clear Cell Renal Cell Carcinoma via SREBP1‐Mediated Transactivation of CD47 [PDF]
Advanced ScienceCancer cell‐intrinsic features (e.g., genetic aberrations and dysregulation of signaling pathways) play pivotal roles in orchestrating the composition and functional state of the immune landscape, which in turn impact tumor progression and response to ...
Zhengfang Liu +14 more
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Lysine Methyltransferases SMYD2 and SMYD3: Emerging Targets in Kidney Diseases [PDF]
Kidney DiseasesBackground: The SET and MYND domain-containing (SMYD) protein family is a group of lysine methyltransferases with SET and MYND domains and plays a critical role in regulating gene expression through the methylation of histone and non-histone ...
Xinyu Du, Liyuan Yao, Shougang Zhuang
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Identifying novel SMYD3 interactors on the trail of cancer hallmarks
Computational and Structural Biotechnology Journal, 2022 SMYD3 overexpression in several human cancers highlights its crucial role in carcinogenesis. Nonetheless, SMYD3 specific activity in cancer development and progression is currently under debate. Taking advantage of a library of rare tripeptides, which we
Candida Fasano +6 more
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The Lysine Methylase SMYD3 Modulates Mesendodermal Commitment during Development [PDF]
Cells, 2021 SMYD3 (SET and MYND domain containing protein 3) is a methylase over-expressed in cancer cells and involved in oncogenesis. While several studies uncovered key functions for SMYD3 in cancer models, the SMYD3 role in physiological conditions has not been ...
Raffaella Fittipaldi +5 more
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Smyd3 is required for the development of cardiac and skeletal muscle in zebrafish.
PLoS ONE, 2011 Modifications of histone tails are involved in the regulation of a wide range of biological processes including cell cycle, cell survival, cell division, and cell differentiation.
Tomoaki Fujii +4 more
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ANKHD1 is required for SMYD3 to promote tumor metastasis in hepatocellular carcinoma [PDF]
Journal of Experimental & Clinical Cancer Research, 2019 Absract Background Tumor metastasis is the major reason for poor prognosis of hepatocellular carcinoma (HCC) patients after hepatic resection. SMYD3 has been demonstrated to promote liver tumor metastasis in mice.
Zhenyu Zhou +12 more
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SMYD3 promotes hepatocellular carcinoma progression by methylating S1PR1 promoters [PDF]
Cell Death and Disease, 2021 Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. SET and MYND domain-containing protein 3 (SMYD3) has been shown to promote the progression of various types of human cancers, including liver cancer; however, the detailed ...
Heyun Zhang +9 more
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Overexpression of SMYD3 Promotes Autosomal Dominant Polycystic Kidney Disease by Mediating Cell Proliferation and Genome Instability [PDF]
BiomedicinesAutosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disorder worldwide and progresses to end-stage renal disease (ESRD). However, its precise mechanism is not fully understood.
Ewud Agborbesong +6 more
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Macrophage-Derived Transcriptional Signatures Predict Prognosis and Drug Sensitivity in Thyroid Cancer: Integrative Analysis and Experimental Validation of SMYD3 [PDF]
ImmunoTargets and TherapySufang Xu, Xin Zhang, Jingru Sun, Man Qin, Huarong Du, Bing Luo Department of Medical Laboratory Center, Anhui No.2 Provincial People’s Hospital, Hefei, Anhui, People’s Republic of ChinaCorrespondence: Bing Luo, Department of Medical Laboratory Center ...
Xu S, Zhang X, Sun J, Qin M, Du H, Luo B
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Small molecule compound ZYZ-384 targets SMYD3 to alleviate aging [PDF]
Scientific ReportsSMYD3 is a chromatin modifier that facilitates the trimethylation of histone 3 lysine 4 (H3K4) to induce diverse biological activities. We have provided a brief demonstration of the anti-aging effect of ZYZ-384, a newly developed inhibitor targeting ...
Yang Liu +6 more
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