Results 31 to 40 of about 1,974 (156)
Canonical and Non-Canonical Functions of Histone H3K4 Methylation Modifiers in Cancer. [PDF]
Cancer SciHistone H3K4‐modifying enzymes regulate gene expression and cellular processes critical to cancer development. Beyond their canonical roles, these enzymes also exhibit non‐catalytic and non‐histone functions, offering new opportunities for therapeutic intervention. ABSTRACT Histone H3K4 modifications are altered in the regulation of gene expression and
Hoshii T.
europepmc +2 more sources
Temporal Nasal Epithelial Gene Expression Patterns in Healthy Individuals Infected With Rhinovirus-16, and Its Modulation by Carrot Rhamnogalacturonan-I. [PDF]
J Med VirolABSTRACT Innate immune and interferon‐induced responses to in vivo nasal infection with rhinovirus (RV)16 in healthy subjects are accelerated by low‐dose dietary supplementation with carrot‐derived pectic polysaccharide rhamnogalacturonan‐I (cRG‐I), together with reduced duration and severity of symptoms.
Mol J +8 more
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Computational and Structural Biotechnology Journal, 2023 SMDY3 is a histone-lysine N-methyltransferase involved in several oncogenic processes and is believed to play a major role in various cancer hallmarks. Recently, we identified ATM, BRCA2, CHK2, MTOR, BLM, MET, AMPK, and p130 as direct SMYD3 interactors ...
Candida Fasano +9 more
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EZH2 and SMYD3 expression in papillary thyroid cancer
Oncology Letters, 2021 Recent studies have revealed the significant role of SMYD3 and EZH2 genes in the development and aggressiveness of numerous types of malignant tumor. Therefore, the present study aimed to investigate the expression of SMYD3 and EZH2 in papillary thyroid cancer, and to determine the correlation between the expression of these genes and clinical ...
Sawicka-Gutaj, Nadia +6 more
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Cell Death and Disease, 2023 Protein lysine methyltransferase SET and MYND domain-containing 3 (SMYD3) is aberrantly expressed in various cancer settings. The mechanisms that SMYD3 activates the expression of critical pro-tumoral genes in an H3K4me3-dependent manner have been well ...
Yi Zeng +7 more
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Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3 [PDF]
ACS Medicinal Chemistry Letters, 2019 SMYD3 is a histone methyltransferase that regulates gene transcription, and its overexpression is associated with multiple human cancers. A novel class of tetrahydroacridine compounds which inhibit SMYD3 through a covalent mechanism of action is identified. Optimization of these irreversible inhibitors resulted in the discovery of 4-chloroquinolines, a
Chuhui Huang +34 more
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BMC Biology, 2022 Background SMYD3, a member of the SET and MYND domain-containing (SMYD) family, is a histone methyltransferase (HMT) and transcription factor that plays an important role in transcriptional regulation in human carcinogenesis.
Yang Yang +13 more
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Frontiers in Oncology, 2021 BackgroundImplantation metastasis is the main means of dissemination in ovarian cancer. Our previous studies showed that SET and MYND domain-containing protein 3 (SMYD3) expression was higher in ovarian cancer spheroids than in monolayers.
Yahui Jiang +4 more
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Cell Death and Disease, 2022 Genetic abnormalities in histone methyltransferases (HMTs) frequently occur in diffuse large B-cell lymphoma (DLBCL) and are related to its progression. SET and MYND domain containing 3 (SMYD3) is an HMT that is upregulated in various tumors and promotes
Tian Tian +7 more
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SMYD3 promotes the epithelial–mesenchymal transition in breast cancer [PDF]
Nucleic Acids Research, 2018 SMYD3 is a methylase previously linked to cancer cell invasion and migration. Here we show that SMYD3 favors TGF-induced epithelial– mesenchymal transition (EMT) in mammary epithelial cells, promoting mesenchymal and EMT transcription factors expression.
Claudio Fenizia +9 more
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