Results 11 to 20 of about 14,870 (188)

Children and Snakebite: Snake Venom Effects on Adult and Paediatric Plasma

open access: yesToxins, 2023
Snakebite is a globally neglected tropical disease, with coagulation disturbances being the primary pathology of many deadly snake venoms. Age-related differences in human plasma have been abundantly reported, yet the effect that these differences pose ...
Christina N. Zdenek   +5 more
doaj   +1 more source

Monitoring Snake Venom-Induced Extracellular Matrix Degradation and Identifying Proteolytically Active Venom Toxins Using Fluorescently Labeled Substrates

open access: yesBiology, 2023
Snakebite envenoming is an important public health issue with devastating consequences and annual mortality rates that range between 81,000 and 138,000.
Mátyás A. Bittenbinder   +8 more
doaj   +1 more source

Application of an Extracellular Matrix-Mimicking Fluorescent Polymer for the Detection of Proteolytic Venom Toxins

open access: yesToxins, 2023
The cytotoxicity caused by snake venoms is a serious medical problem that greatly contributes to the morbidity observed in snakebite patients. The cytotoxic components found in snake venoms belong to a variety of toxin classes and may cause cytotoxic ...
Eric Wachtel   +8 more
doaj   +1 more source

Polyvalent Snake Antivenoms: Production Strategy and Their Therapeutic Benefits

open access: yesToxins, 2023
Snake envenomation remains an important yet neglected medical problem in many countries, with around five million people affected, and over a hundred thousand deaths annually. Plasma-derived antivenoms are the main therapeutic agent available. Monovalent
Kavi Ratanabanangkoon
doaj   +1 more source

Viperidae snake venom phospholipase A2 . Biochemical targets for the action of protein in the human blood circulatory system. Part 1 (review of literature)

open access: yesУчёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2022
Snake venoms have been fervently studied for decades for two reasons: 1) high death rate due to snake bites; 2) numerous components of snake venoms prove useful in medicine and treatment of diverse pathologies. Snake venom phospholipases A2 are among the
L. V. Galebskaya   +3 more
doaj   +1 more source

Role of Phospholipases A2 in Vascular Relaxation and Sympatholytic Effects of Five Australian Brown Snake, Pseudonaja spp., Venoms in Rat Isolated Tissues

open access: yesFrontiers in Pharmacology, 2021
Human envenoming by Australian brown snakes (Pseudonaja spp.) may result in potentially life-threatening hypotension and subsequent cardiovascular collapse.
Nhi Thuc Vuong   +2 more
doaj   +1 more source

Snake Venoms in Cancer Therapy: Past, Present and Future

open access: yesToxins, 2018
Cancer is one of the leading causes of morbidity and mortality worldwide, and the discovery of new drugs for cancer therapy is one of the most important objectives for the pharmaceutical industry.
Li Li, Jianzhong Huang, Yao Lin
doaj   +1 more source

Snake Venom: A Promising Source of Neurotoxins Targeting Voltage-Gated Potassium Channels

open access: yesToxins, 2023
The venom derived from various sources of snakes represents a vast collection of predominantly protein-based toxins that exhibit a wide range of biological actions, including but not limited to inflammation, pain, cytotoxicity, cardiotoxicity, and ...
Altaf K. AlShammari   +2 more
doaj   +1 more source

Snake Venoms in Drug Discovery: Valuable Therapeutic Tools for Life Saving

open access: yesToxins, 2019
Animal venoms are used as defense mechanisms or to immobilize and digest prey. In fact, venoms are complex mixtures of enzymatic and non-enzymatic components with specific pathophysiological functions.
Tarek Mohamed Abd El-Aziz   +2 more
doaj   +1 more source

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