Results 41 to 50 of about 10,248 (218)

Proteomic Investigations of Two Pakistani Naja Snake Venoms Species Unravel the Venom Complexity, Posttranslational Modifications, and Presence of Extracellular Vesicles

, 2020
Latest advancement of omics technologies allows in-depth characterization of venom compositions. In the present work we present a proteomic study of two snake venoms of the genus Naja i.e., Naja naja (black cobra) and Naja oxiana (brown cobra) of ...
Zia Mughal, Syed Abid Ali, Aisha Manuwar, Andreas Böhmert, Anwar Ullah, Ahmed Akrem, Benjamin Dreyer, Hartmut Schlüter, Christian Betzel   +8 more
core   +1 more source

Elapid Snake Venom Analyses Show the Specificity of the Peptide Composition at the Level of Genera Naja and Notechis

Toxins, 2014
Elapid snake venom is a highly valuable, but till now mainly unexplored, source of pharmacologically important peptides. We analyzed the peptide fractions with molecular masses up to 10 kDa of two elapid snake venoms—that of the African cobra, N.
Aisha Munawar, Maria Trusch, Dessislava Georgieva, Diana Hildebrand, Marcel Kwiatkowski, Henning Behnken, Sönke Harder, Raghuvir Arni, Patrick Spencer, Hartmut Schlüter, Christian Betzel   +10 more
doaj   +1 more source

Screening Snake Venoms for Toxicity to Tetrahymena Pyriformis Revealed Anti-Protozoan Activity of Cobra Cytotoxins

, 2020
Snake venoms possess lethal activities against different organisms, ranging from bacteria to higher vertebrates. Several venoms were shown to be active against protozoa, however, data about the anti-protozoan activity of cobra and viper venoms are very ...
Vladislav Starkov, Elena Kruykova, Victor Tsetlin, Elena Cheremnykh, Olga Kuleshina, Yuri Utkin, Alexey Osipov, Leonid Kozlov, Rustam Ziganshin, Tatyana Andreeva   +9 more
core   +1 more source

Snake bite in South Asia: a review

, 2010
Snake bite is one of the most neglected public health issues in poor rural communities living in the tropics. Because of serious misreporting, the true worldwide burden of snake bite is not known.
Alirol, Emilie, Sharma Sanjib Kumar, Kuch, Ulrich, Sharma, Sanjib Kumar, Sanjib Kumar Sharma, Alirol Emilie, Bawaskar, Himmatrao Saluba, Emilie Alirol, François Chappuis, Kuch Ulrich, Ulrich Kuch, Himmatrao Saluba Bawaskar, Chappuis, François, Chappuis François, Bawaskar Himmatrao Saluba   +14 more
core   +1 more source

The Target Selects the Toxin: Specific Amino Acids in Snake-Prey Nicotinic Acetylcholine Receptors That Are Selectively Bound by King Cobra Venoms [PDF]

, 2022
Snake venom is an adaptive ecological trait that has evolved primarily as a form of prey subjugation. Thus, the selection pressure for toxin diversification is exerted by the prey’s physiological targets, with this pressure being particularly acute for ...
Uthpala Chandrasekara, Richard J. Harris, Harris, Richard J., Fry, Bryan G., Chandrasekara, Uthpala, Bryan G. Fry   +5 more
core   +1 more source

Protease activity profiling of snake venoms using high-throughput peptide screening [PDF]

, 2019
Snake venom metalloproteinases (SVMPs) and snake venom serine proteinases (SVSPs) are among the most abundant enzymes in many snake venoms, particularly among viperids. These proteinases are responsible for some of the clinical manifestations classically
Andreas Treschow, Andreas Laustsen, Rucavado Romero, Alexandra, Andreas Hougaard Laustsen, Rucavado, Alexandra, Laustsen, Andreas Hougaard, Christopher T. Workman, Escalante, Teresa, Alexandra Rucavado, Konstantinos Kalogeropoulos, José Gutiérrez, Kalogeropoulos, Konstantinos, Christopher Workman, Workman, Christopher T., Ulrich auf dem Keller, Keller, Ulrich auf dem, Treschow, Andreas Frederik, Andreas Frederik Treschow, José María Gutiérrez, Auf Dem Keller, Ulrich, Escalante Muñoz, Teresa, Teresa Escalante, Gutiérrez, José María   +22 more
core   +1 more source

Cytotoxicity and morphological analysis of cell death induced by Bothrops venoms from the northeast of Argentina

Journal of Venomous Animals and Toxins including Tropical Diseases, 2009
Bothrops snake venoms have been proved toxic to a variety of cell types, in both in vivo and in vitro models. Studies on the pharmacological actions of Bothrops venoms from Argentina are relatively scarce and the direct action of the crude venoms has not
S Bustillo, H Lucero, LC Leiva, O Acosta, EB Kier Joffé, JO Gorodner   +5 more
doaj   +1 more source

Varespladib (LY315920) and Methyl Varespladib (LY333013) Abrogate or Delay Lethality Induced by Presynaptically Acting Neurotoxic Snake Venoms

, 2020
The phospholipase A2 (PLA2) inhibitor Varespladib (LY315920) and its orally bioavailable prodrug, methyl-Varespladib (LY333013) inhibit PLA2 activity of a wide variety of snake venoms.
Bruno Lomonte, Williams, David J., Lewin, Matthew R., Matthew R. Lewin, José María Gutiérrez, Lomonte, Bruno, Gutiérrez, José María, David. J. Williams   +7 more
core   +1 more source

Snake a-Neurotoxins and the Nicotinic Acetylcholine Receptor

, 2016
α-Neurotoxins from snake venoms act on postsynaptic nicotinic acetylcholine receptors at the neuromuscular junction to produce clinically significant skeletal muscle paralysis following envenomation.
Nirthanan, Niru, Selvanayagam Nirthanan, Navin R. Niranjan, Awal, Wasim, Niranjan, Navin R., Wasim Awal   +5 more
core   +1 more source

Much more than their fangs: Macroscopic anatomy of the brain of Bothrops moojeni Hoge 1966 (Squamata, Serpentes, Viperidae)

The Anatomical Record, EarlyView.
Abstract Neuroanatomical research has progressed considerably in several vertebrate lineages, yet studies of reptilian brain morphology remain markedly underdeveloped. Here we provide the first description of macroscopic brain anatomy and its ontogeny in the viperid Bothrops moojeni, based on a sample of seven individuals.
Paula Araújo, Júlio César Costa de Souza, Angele Martins   +2 more
wiley   +1 more source