Polyvalent Snake Antivenoms: Production Strategy and Their Therapeutic Benefits
Toxins, 2023 Snake envenomation remains an important yet neglected medical problem in many countries, with around five million people affected, and over a hundred thousand deaths annually. Plasma-derived antivenoms are the main therapeutic agent available. Monovalent
Kavi Ratanabanangkoon
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Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2022 Snake venoms have been fervently studied for decades for two reasons: 1) high death rate due to snake bites; 2) numerous components of snake venoms prove useful in medicine and treatment of diverse pathologies. Snake venom phospholipases A2 are among the
L. V. Galebskaya +3 more
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Frontiers in Pharmacology, 2021 Human envenoming by Australian brown snakes (Pseudonaja spp.) may result in potentially life-threatening hypotension and subsequent cardiovascular collapse.
Nhi Thuc Vuong +2 more
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Snake Venom: A Promising Source of Neurotoxins Targeting Voltage-Gated Potassium Channels
Toxins, 2023 The venom derived from various sources of snakes represents a vast collection of predominantly protein-based toxins that exhibit a wide range of biological actions, including but not limited to inflammation, pain, cytotoxicity, cardiotoxicity, and ...
Altaf K. AlShammari +2 more
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Tissue Localization and Extracellular Matrix Degradation by PI, PII and PIII Snake Venom Metalloproteinases: Clues on the Mechanisms of Venom-Induced Hemorrhage [PDF]
, 2015 20 páginas, 4 figuras, 3 tablas y 7 tablas en material suplementario.Snake venom hemorrhagic metalloproteinases (SVMPs) of the PI, PII and PIII classes were compared in terms of tissue localization and their ability to hydrolyze basement membrane ...
A Osaka +52 more
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Histopathological analysis and in situ localisation of Australian tiger snake venom in two clinically envenomed domestic animals [PDF]
, 2011 Objective: To assess histopathological changes in clinically envenomed tiger snake patients and identify tissue specific localisation of venom toxins using immunohistochemistry.
Balmer, L. +5 more
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Biochemical comparison of venoms from young Colombian Crotalus durissus cumanensis and their parents
Journal of Venomous Animals and Toxins including Tropical Diseases, 2010 Crotalus durissus cumanensis, a rattlesnake endemic to Colombia and Venezuela, is considered one of the most lethal snake species in Latin America. The aim of the present study was to compare the protein content and biological activity of the venom ...
N Céspedes +7 more
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Purification of a fragment obtained by autolysis of a PIIIb-SVMP from Bothrops alternatus venom [PDF]
, 2018 Snake Venom Metalloproteinases (SVMPs) represent 43.1% of the components in Bothrops alternatus venom and play an important role in envenomation. Disintegrins and disintegrin-like domains are released by proteolytic processing of PII and PIII classes of ...
Acosta, Ofelia Cristina +9 more
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Mass spectrometry in snake venom research
Acta Biologica Slovenica, 2022 Mass spectrometry allows rapid and reliable identification and characterisation of proteins and peptides in snake venoms. With the increasing availability of transcriptomic and genomic data, there is a growing database of protein sequences that is ...
Adrijana Leonardi
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Comparison of phylogeny, venom composition and neutralization by antivenom in diverse species of bothrops complex. [PDF]
PLoS Neglected Tropical Diseases, 2013 In Latin America, Bothrops snakes account for most snake bites in humans, and the recommended treatment is administration of multispecific Bothrops antivenom (SAB--soro antibotrópico).
Leijiane F Sousa +11 more
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