Results 31 to 40 of about 7,174 (182)

Snake venoms and hemostasis [PDF]

Journal of Thrombosis and Haemostasis, 2005
Snake venoms are complex mixtures of biologically active proteins and peptides. Many of them affect hemostasis by activating or inhibiting coagulant factors or platelets, or by disrupting endothelium. Based on sequence, these snake venom components have been classified into various families, such as serine proteases, metalloproteinases, C-type lectins,
Lu, Q, Clemetson, JM, Clemetson, Kenneth John   +2 more
openaire   +4 more sources

Profiling the Murine Acute Phase and Inflammatory Responses to African Snake Venom: An Approach to Inform Acute Snakebite Pathology

Toxins, 2022
Snake envenoming causes rapid systemic and local effects that often result in fatal or long-term disability outcomes. It seems likely that acute phase and inflammatory responses contribute to these haemorrhagic, coagulopathic, neurotoxic, nephrotoxic and
Jaffer Alsolaiss, Chloe A. Evans, George O. Oluoch, Nicholas R. Casewell, Robert A. Harrison   +4 more
doaj   +1 more source

Hybridization between Crotalus aquilus and Crotalus polystictus Species: A Comparison of Their Venom Toxicity and Enzymatic Activities

Biology, 2022
Hybridization is defined as the interbreeding of individuals from two populations distinguishable by one or more heritable characteristics. Snake hybridization represents an interesting opportunity to analyze variability and how genetics affect the venom
Octavio Roldán-Padrón, Martha Sandra Cruz-Pérez, José Luis Castro-Guillén, José Alejandro García-Arredondo, Elizabeth Mendiola-Olaya, Carlos Saldaña-Gutiérrez, Patricia Herrera-Paniagua, Alejandro Blanco-Labra, Teresa García-Gasca   +8 more
doaj   +1 more source

Elapid Snake Venom Analyses Show the Specificity of the Peptide Composition at the Level of Genera Naja and Notechis

Toxins, 2014
Elapid snake venom is a highly valuable, but till now mainly unexplored, source of pharmacologically important peptides. We analyzed the peptide fractions with molecular masses up to 10 kDa of two elapid snake venoms—that of the African cobra, N.
Aisha Munawar, Maria Trusch, Dessislava Georgieva, Diana Hildebrand, Marcel Kwiatkowski, Henning Behnken, Sönke Harder, Raghuvir Arni, Patrick Spencer, Hartmut Schlüter, Christian Betzel   +10 more
doaj   +1 more source

Cytotoxicity and morphological analysis of cell death induced by Bothrops venoms from the northeast of Argentina

Journal of Venomous Animals and Toxins including Tropical Diseases, 2009
Bothrops snake venoms have been proved toxic to a variety of cell types, in both in vivo and in vitro models. Studies on the pharmacological actions of Bothrops venoms from Argentina are relatively scarce and the direct action of the crude venoms has not
S Bustillo, H Lucero, LC Leiva, O Acosta, EB Kier Joffé, JO Gorodner   +5 more
doaj   +1 more source

Chemically Regulated STING‐Activating Prodrugs of Deoxyribose Cyclic Dinucleotides Elicit Robust Immune Activation and Durable Antitumor Immunity

Angewandte Chemie International Edition, EarlyView.
All three diastereoisomers of an esterase‐sensitive phosphotriester dCDN prodrug demonstrate improved activity. The (Rp,Rp) diastereoisomer shows the highest activity with an EC50 of 1.7 nM in STING activation and displays the most pronounced antitumor activity via intravenous administration, significantly suppressing tumor proliferation, extending the
Zhiqiang Xie, Huimin Liu, Yuchen Yang, Xiaohan Sun, Jingwen Wang, Tianxiang Liu, Baifan Wang, Wenrui Qiu, Yiwen Sun, Yuting Bai, Yao Zhang, Dejun Ma, Rong Xiang, Shibo Li, Zhen Xi   +14 more
wiley   +1 more source

Evaluation of Antifungal Activity of Naja pallida and Naja mossambica Venoms against Three Candida Species

Toxins, 2020
In contrast to comprehensively investigated antibacterial activity of snake venoms, namely crude venoms and their selected components, little is known about antifungal properties of elapid snake venoms. In the present study, the proteome of two venoms of
Ewelina Kuna, Aleksandra Bocian, Konrad K. Hus, Vladimir Petrilla, Monika Petrillova, Jaroslav Legath, Anna Lewinska, Maciej Wnuk   +7 more
doaj   +1 more source

Snake Venom Metalloproteinases [PDF]

, 2017
UCR::Vicerrectoría de Docencia::Salud::Facultad de ...
openaire   +1 more source

Much more than their fangs: Macroscopic anatomy of the brain of Bothrops moojeni Hoge 1966 (Squamata, Serpentes, Viperidae)

The Anatomical Record, EarlyView.
Abstract Neuroanatomical research has progressed considerably in several vertebrate lineages, yet studies of reptilian brain morphology remain markedly underdeveloped. Here we provide the first description of macroscopic brain anatomy and its ontogeny in the viperid Bothrops moojeni, based on a sample of seven individuals.
Paula Araújo, Júlio César Costa de Souza, Angele Martins   +2 more
wiley   +1 more source

High throughput screening and identification of coagulopathic snake venom proteins and peptides using nanofractionation and proteomics approaches.

PLoS Neglected Tropical Diseases, 2020
Snakebite is a neglected tropical disease that results in a variety of systemic and local pathologies in envenomed victims and is responsible for around 138,000 deaths every year.
Julien Slagboom, Marija Mladić, Chunfang Xie, Taline D Kazandjian, Freek Vonk, Govert W Somsen, Nicholas R Casewell, Jeroen Kool   +7 more
doaj   +1 more source