Differential Effects of Marimastat and Prinomastat on the Metalloprotease Activity of Various Snake Venoms [PDF]
ToxinsSnakebite envenoming is a neglected tropical disease, responsible for approximately 140,000 deaths globally each year. Vipers and elapid snakes represent the most significant snake families in medical contexts, exhibiting a variety of venom components ...
Mahtab Khatibi +6 more
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Snake Venoms in Drug Discovery: Valuable Therapeutic Tools for Life Saving
Toxins, 2019 Animal venoms are used as defense mechanisms or to immobilize and digest prey. In fact, venoms are complex mixtures of enzymatic and non-enzymatic components with specific pathophysiological functions.
Tarek Mohamed Abd El Aziz +1 more
exaly +4 more sources
Two-Dimensional Blue Native/SDS Polyacrylamide Gel Electrophoresis for Analysis of Brazilian Bothrops Snake Venoms [PDF]
Toxins, 2022 Viperidae snakes are the most important agents of snakebites in Brazil. The protein composition of snake venoms has been frequently analyzed by means of electrophoretic techniques, but the interaction of proteins in venoms has barely been addressed.
Natacha Ferreira de Oliveira +2 more
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Snake Venoms in Cancer Therapy: Past, Present and Future
Toxins, 2018 Cancer is one of the leading causes of morbidity and mortality worldwide, and the discovery of new drugs for cancer therapy is one of the most important objectives for the pharmaceutical industry.
Xiaolei Guo, Yao Lin
exaly +4 more sources
Antiprotozoal Effect of Snake Venoms and Their Fractions: A Systematic Review [PDF]
Pathogens, 2021 Background: Protozoal infection is a lingering public health issue of great concern, despite efforts to produce drugs and vaccines against it. Recent breakthrough research has discovered alternative antiprotozoal agents encompassing the use of snake ...
Zainab U. Abdullahi +3 more
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Children and Snakebite: Snake Venom Effects on Adult and Paediatric Plasma
Toxins, 2023 Snakebite is a globally neglected tropical disease, with coagulation disturbances being the primary pathology of many deadly snake venoms. Age-related differences in human plasma have been abundantly reported, yet the effect that these differences pose ...
Christina N. Zdenek +5 more
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Development of a high-throughput in vitro screening method for the assessment of cell-damaging activities of snake venoms. [PDF]
PLoS Neglected Tropical Diseases, 2023 Snakebite envenoming is a globally important public health issue that has devastating consequences on human health and well-being, with annual mortality rates between 81,000 and 138,000.
Matyas A Bittenbinder +8 more
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Snake Venom: A Promising Source of Neurotoxins Targeting Voltage-Gated Potassium Channels
Toxins, 2023 The venom derived from various sources of snakes represents a vast collection of predominantly protein-based toxins that exhibit a wide range of biological actions, including but not limited to inflammation, pain, cytotoxicity, cardiotoxicity, and ...
Altaf K. AlShammari +2 more
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Toxins, 2020 Snake venoms contain components selected to immobilize prey. The venoms from Elapidae mainly contain neurotoxins, which are critical for rapid prey paralysis, while the venoms from Viperidae and Colubridae may contain fewer neurotoxins but are likely to ...
Huiwen Tian +9 more
doaj +2 more sources
Applications of snake venoms in treatment of cancer
Asian Pacific Journal of Tropical Biomedicine, 2015 Snake venoms are folk medicines used since ages. The components of snake venoms have high specific affinity and actions on cells and cell components. Also snake venoms are largely cytotoxic to tumor cells than normal cells.
Vagish Kumar Laxman Shanbhag
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