Results 81 to 90 of about 15,264 (232)
Engineering the Rod of Asclepius – A Biochemical Investigation of Snake Venom Components and their Application as Potential Cancer Treatments [PDF]
, 2019 In the wild, venom is crucial to many snakes’ success as predators. While antivenin research focuses on combatting venoms’ abilities to disrupt physiological processes, new studies are attempting to manipulate these same abilities into anticancer ...
Pena, Noel
core +1 more source
Role of accelerated segment switch in exons to alter targeting (ASSET) in the molecular evolution of snake venom proteins [PDF]
, 2009 BACKGROUND: Snake venom toxins evolve more rapidly than other proteins through accelerated changes in the protein coding regions. Previously we have shown that accelerated segment switch in exons to alter targeting (ASSET) might play an important role in
Robin Doley +2 more
core +2 more sources
VIEW, EarlyView.Cancer‐associated fibroblasts exert intricate mechanisms in the progression and metastasis of renal cell carcinoma. Existing studies have validated the relevant mechanisms of three signaling pathways, which hold promising potential as novel therapeutic targets.
Ruiqiang Sun +4 more
wiley +1 more source
Transcriptomic basis for an antiserum against Micrurus corallinus (coral snake) venom [PDF]
, 2009 Background Micrurus corallinus (coral snake) is a tropical forest snake belonging to the family Elapidae. Its venom shows a high neurotoxicity associated with pre- and post-synaptic toxins, causing diaphragm paralysis, which may result in death. In spite
Luciana I Leão +2 more
core +2 more sources
‘I, Me, Myself’: Selfhood and Melancholy in the Journals of Gertrude Savile (1697–1758)
Journal for Eighteenth-Century Studies, EarlyView.Abstract This article examines the journals of Gertrude Savile from 1727 in light of recent scholarship on early modern and eighteenth‐century melancholy. The concept had myriad associations with medicine, physiology, the imagination, and feeling, but questions remain about how melancholy during this period was considered by those outside the narrow ...
Daniel Beaumont
wiley +1 more source
Colubrid Venom Composition: An -Omics Perspective
Toxins, 2016 Snake venoms have been subjected to increasingly sensitive analyses for well over 100 years, but most research has been restricted to front-fanged snakes, which actually represent a relatively small proportion of extant species of advanced snakes ...
Inácio L. M. Junqueira-de-Azevedo +3 more
doaj +1 more source
Antiviral activity of animal venom peptides and related compounds [PDF]
, 2017 Viruses exhibit rapid mutational capacity to trick and infect host cells, sometimes assisted through virus-coded peptides that counteract host cellular immune defense.
Mata, Élida Cleyse Gomes da Mata +3 more
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Nanofibrous Snake Venom Hemostat [PDF]
ACS Biomaterials Science & Engineering, 2015 Controlling perioperative bleeding is of critical importance to minimize hemorrhaging and fatality. Patients on anticoagulant therapy such as heparin have diminished clotting potential and are at risk for hemorrhaging. Here we describe a self-assembling nanofibrous peptide hydrogel (termed SLac) that on its own can act as a physical barrier to blood ...
Kumar, Vivek A. +3 more
openaire +3 more sources
Cancer pain: current practice and emerging targets
British Journal of Pharmacology, EarlyView.Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye +5 more
wiley +1 more source
Factors underlying the natural resistance of animals against snake venoms
Memorias do Instituto Oswaldo Cruz, 1989 The existence of mammals and reptilia with a natural resistance to snake venoms is known since a long time. This fact has been subjected to the study by several research workers.
H. Moussatché, J. Perales
doaj +1 more source