Results 71 to 80 of about 10,248 (218)

Shortcomings in snake bite management in rural Cameroon: a case report

BMC Research Notes, 2017
Background Snake bites are an important public health problem in developing countries with most bites occurring in rural areas. Severe envenomation often occurs in children and following bites to the face.
Frank-Leonel Tianyi, Christian Akem Dimala, Vitalis Fambombi Feteh   +2 more
doaj   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Neutralizing Effects of Small Molecule Inhibitors and Metal Chelators on Coagulopathic Viperinae Snake Venom Toxins

Biomedicines, 2020
Animal-derived antivenoms are the only specific therapies currently available for the treatment of snake envenoming, but these products have a number of limitations associated with their efficacy, safety and affordability for use in tropical snakebite ...
Chunfang Xie, Laura-Oana Albulescu, Mátyás A. Bittenbinder, Govert W. Somsen, Freek J. Vonk, Nicholas R. Casewell, Jeroen Kool   +6 more
doaj   +1 more source

Retrieving Your Concepts: Iris Murdoch on Original Sin

European Journal of Philosophy, EarlyView.
Abstract In The Sovereignty of Good, Iris Murdoch argues that our moral thinking will be impoverished until it possesses a secular conception of original sin. Such a notion would need to remove unacceptable Christian baggage while retaining a genuine claim to be a descendant of the original Christian concept.
Samuel Filby
wiley   +1 more source

Phospholipase A(2) Inhibitors from Snake Blood (sbPLIs)

, 2017
Several snake species have been naturally provided with protein inhibitors with the primary aim of self-protection against the eventual presence of venom toxins in their circulating blood.
Rahmy, T. R., Fortes-Dias, Consuelo L., Gopalakrishnakone, P., Mukherjee, A. K., Campos, Patricia Cota, Inagaki, H., Vogel, C. W., Fontes, Marcos Roberto M. [UNESP], Fernandes, Carlos Alexandre H. [UNESP]   +8 more
core   +1 more source

Cross neutralization of Afro-Asian cobra and Asian krait venoms by a Thai polyvalent snake antivenom (Neuro Polyvalent Snake Antivenom). [PDF]

PLoS Neglected Tropical Diseases, 2012
BACKGROUND: Snake envenomation is a serious public health threat in the rural areas of Asian and African countries. To date, the only proven treatment for snake envenomation is antivenom therapy.
Poh Kuan Leong, Si Mui Sim, Shin Yee Fung, Khomvilai Sumana, Visith Sitprija, Nget Hong Tan   +5 more
doaj   +1 more source

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

The effect of a serum containing acetyl hexapeptide‐8, dipeptide diaminobutyroyl benzylamide diacetate and gluconolactone on skin biomarkers, wrinkles and skin texture: Ex vivo and clinical studies

International Journal of Cosmetic Science, EarlyView.
The novel serum demonstrates significant anti‐skin aging effects, effectively improving static and dynamic wrinkles and skin texture. Therefore, this formulation holds promise as a safe and effective product in the field of anti‐wrinkle skincare products.
Mingjie Zhu, Xiaofeng He, Zailing Zhu, Stephen Lynch, Hequn Wang, Xiaoyin Zhou, Yidong Tu, Andrew Steel, Kung Chi Hsu, Yueqing Niu, Anna Cho, Mutsue Hashimoto, Xi Yan, Maggie Su, Wenna Wang   +14 more
wiley   +1 more source

Convergent Total Synthesis of 16β‐Hydroxylpseudobufarenogin

Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.
We present a novel convergent strategy that integrates Pd/Ag‐promoted Suzuki–Miyaura coupling with Ir‐catalyzed radical‐relay cyclization, enabling the first total synthesis of 16β‐hydroxylpseudobufarenogin. This approach is broadly applicable to the total synthesis of various oxygenated bufadienolides by simply modifying the fragment structures ...
Wataru Shigematsu, Yo Matsumoto, Koichi Hagiwara, Masayuki Inoue   +3 more
wiley   +2 more sources

Erythrocyte ‘Feierzeit’ reaction: Novel filamentous and vesicular response to n‐butyl acetate

Journal of Microscopy, EarlyView.
Abstract Human erythrocytes (red blood cells; RBCs) undergo spontaneous disassembly after several hours of exposure to n‐butyl acetate (nBA). Images of the morphological changes were captured in time‐lapse sequences using differential interference contrast (DIC) light microscopy.
Philip W. Kuchel
wiley   +1 more source