Results 101 to 110 of about 150,506 (397)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Ykt6 mediates autophagosome-vacuole fusion
Molecular & Cellular Oncology, 2018 Studying the mechanism of autophagosome-vacuole fusion has proven difficult in live yeast cells. Developing a novel in vitro fusion assay, we identified Ykt6 as the missing R-SNARE (Soluble N-ethylmaleimide sensitive factor attachment protein receptor ...
Levent Bas +2 more
doaj +1 more source
Non-canonical role of the SNARE protein Ykt6 in autophagosome-lysosome fusion
PLoS Genetics, 2018 The autophagosomal SNARE Syntaxin17 (Syx17) forms a complex with Snap29 and Vamp7/8 to promote autophagosome-lysosome fusion via multiple interactions with the tethering complex HOPS.
Szabolcs Takáts +7 more
semanticscholar +1 more source
Clathrin Heavy Chain subunits coordinate endo- and exocytic traffic and affect stomatal movement [PDF]
, 2017 The current model for vesicular traffic to and from the plasma membrane is accepted but the molecular requirements for this coordination are not well defined.
Blatt, Michael R. +4 more
core +2 more sources
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Amyloid-β Oligomers May Impair SNARE-Mediated Exocytosis by Direct Binding to Syntaxin 1a
Cell Reports, 2015 Alzheimer’s disease (AD) is closely associated with synaptic dysfunction, and thus current treatments often aim to stimulate neurotransmission to improve cognitive impairment.
Yoosoo Yang +7 more
doaj +1 more source
Trans-SNARE complex dynamics and number determine nascent fusion pore properties
Nature, 2018 The fusion pore is the first crucial intermediate formed during exocytosis, yet little is known about the mechanisms that determine the size and kinetic properties of these transient structures.
Huan Bao +9 more
semanticscholar +1 more source
PASSIVE TORQUE SIMULATION OF SMALL ANGULAR CONTACT BEARING AT HIGH SPEED [PDF]
, 2017 Description of common ball bearing torque models was presented and adopted to the complex thermo-mechanical model of the high speed spindle. Ball bearing passive torque was measured on the own high-speed spindle design.
Kekula J., Smolík J., Sulitka M.
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source