Results 91 to 100 of about 55,518 (304)
JAMA: The Journal of the American Medical Association, 1906 This is one of a series of instruments designed for nose and throat work, the special feature of each being the "pistol grip" handle, which allows the operator an unobstructed view of the field of operation and an easy natural position which does not cramp the hand or fingers.
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Cryoimmunoelectron microscopic localization of synaptic proteins in nerve terminals and astrocytic cells [PDF]
, 2004 In the present study the cryo-immunogold technique was used and optimized for investigating the ultrastructure and immunolabeling of synaptic proteins. It is evidently a suitable method for the localization of membrane proteins since the antigens are not
Zhang, Lixia
core
, 2011 SNARE proteins play a critical role in intracellular membrane fusion by forming tight complexes that bring two membranes together and involve sequences called SNARE motifs.
Wei Li +3 more
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PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
SNARE regulators: matchmakers and matchbreakers [PDF]
, 2003 SNAREs (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptors) are membrane-associated proteins that participate in the fusion of internal membranes in eukaryotic cells.
Gerst, Jeffrey E.
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AN IMPROVED TONSIL SNARE [PDF]
Journal of the American Medical Association, 1911 The instrument and its various parts are so well shown in the illustrations that no further description is necessary. It is a more powerful instrument than the ordinary tonsil snare and does not get out of order like many others. It is simple in application, can be used a number of times without requiring a new wire, and, if properly adjusted, the wire
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ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
SNARE-like bacterial proteins inhibit endocytic SNARE-mediated membrane fusion.
, 2013 A- CtrIncA encodes a transmembrane domain (aa34–82), a N-terminal (N-ter: aa107–145) and a C-terminal (C-ter: aa210–272) SNARE-like motif. B- VAMP8 was reconstituted with and without CtrIncA into donor liposomes (coomassie gel), and incubated with t ...
Howard A. Shuman (51487) +7 more
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