Results 71 to 80 of about 29,293 (286)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
, 2014 The soluble N-ethylmaleimide-sensitive factor attachment receptor (SNARE) proteins are small and abundant membrane-bound proteins, whose specific interactions mediate membrane fusion during cell fusion or cellular trafficking.
Jiang TJ +8 more
core +1 more source
BMC Genomics, 2009 Background Subcellular trafficking is a hallmark of eukaryotic cells. Because of their pivotal role in the process, a great deal of attention has been paid to the SNARE proteins.
Dacks Joel B +3 more
doaj +1 more source
Role of SNAREs in Unconventional Secretion—Focus on the VAMP7-Dependent Secretion
Frontiers in Cell and Developmental Biology, 2022 Intracellular membrane protein trafficking is crucial for both normal cellular physiology and cell-cell communication. The conventional secretory route follows transport from the Endoplasmic reticulum (ER) to the plasma membrane via the Golgi apparatus ...
Somya Vats, Thierry Galli, Thierry Galli
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Dilation of fusion pores by crowding of SNARE proteins. [PDF]
Elife, 2017 Hormones and neurotransmitters are released through fluctuating exocytotic fusion pores that can flicker open and shut multiple times. Cargo release and vesicle recycling depend on the fate of the pore, which may reseal or dilate irreversibly. Pore nucleation requires zippering between vesicle-associated v-SNAREs and target membrane t-SNAREs, but the ...
Wu Z +7 more
europepmc +6 more sources
SNAP-29: A general SNARE protein that inhibits SNARE disassembly and is implicated in synaptic transmission [PDF]
Proceedings of the National Academy of Sciences, 2001 Using the yeast two-hybrid system with syntaxin-1A as bait, we isolated soluble NSF attachment protein (SNAP)-29 from a human brain cDNA library. Synaptosomal fractionation and immunocytochemical staining of hippocampal neurons in culture showed that SNAP-29 is present at synapses and is predominantly associated with synaptic vesicles.
Q, Su +4 more
openaire +2 more sources
Molecular insights into the transport lectin function of ERGIC-53 [PDF]
, 2004 Secretion of proteins is an essential function of eukaryotic cells. The secretory proteins’ journey along the organelles of the exocytic pathway is initiated by the exit from the endoplasmic reticulum (ER), which defines a major rate-limiting step for ...
Appenzeller-Herzog, Christian
core +1 more source
Munc18-1-regulated stage-wise SNARE assembly underlying synaptic exocytosis
eLife, 2015 Synaptic-soluble N-ethylmaleimide-sensitive factor attachment receptor (SNARE) proteins couple their stage-wise folding/assembly to rapid exocytosis of neurotransmitters in a Munc18-1-dependent manner.
Lu Ma +6 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source