Results 81 to 90 of about 29,293 (286)
The Specificity of Vesicle Trafficking: Coat Proteins and SNAREs [PDF]
The Plant Cell, 1999 Proteins that are destined for the secretory system usually begin their journey at the endoplasmic reticulum (ER), where proteins are translocated across the ER membrane into the lumen, before being selectively removed from the ER and packaged as cargo into transport vesicles bound for the stacks ...
A A, Sanderfoot, N V, Raikhel
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
SNARE proteins and ‘membrane rafts’
The Journal of Physiology, 2007 The original ‘lipid raft’ hypothesis proposed that lipid‐platforms/rafts form in the exoplasmic plasmalemmal leaflet by tight clustering of sphingolipids and cholesterol. Their physical state, presumably similar to liquid‐ordered phases in model membranes, would confer detergent resistance to rafts and enriched proteins therein.
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SNARE Complex–Associated Proteins and Alcohol [PDF]
Alcoholism: Clinical and Experimental Research, 2019 Alcohol addiction causes major health problems throughout the world, causing numerous deaths and incurring a huge economic burden to society. To develop an intervention for alcohol addiction, it is necessary to identify molecular target(s) of alcohol and associated molecular mechanisms of alcohol action.
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eLife, 2014 Secretory and endolysosomal fusion events are driven by SNAREs and cofactors, including Sec17/α-SNAP, Sec18/NSF, and Sec1/Munc18 (SM) proteins. SMs are essential for fusion in vivo, but the basis of this requirement is enigmatic.
Braden T Lobingier +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Decoding the Interactions of SM Proteins with SNAREs [PDF]
The Scientific World JOURNAL, 2005 The success and efficiency of fusion of transport vesicles to target membranes depend upon sets of proteins that are functionally and evolutionarily conserved. The solubleN-ethylmaleimide-sensitive fusion (NSF)-attachment protein receptor (SNARE) family and the Sec1/Munc18 family, also termed SM proteins, are central players in this process.
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Regulation of Growth Cone Extension by SNARE Proteins [PDF]
Journal of Histochemistry & Cytochemistry, 2003 Recent studies have suggested that the soluble N-ethylmaleimide-sensitive factor attached protein (SNAP) receptor (SNARE)-mediated membrane fusion system is involved in vesicle fusion with the surface plasma membrane, which leads to neurite elongation.
Kazushi, Kimura +2 more
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Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways [PDF]
, 2007 Rab family guanosine triphosphatases (GTPases) together with their regulators define specific pathways of membrane traffic within eukaryotic cells. In this study, we have investigated which Rab GTPase-activating proteins (GAPs) can interfere with the ...
Evelyn Fuchs +18 more
core +1 more source