Results 171 to 180 of about 15,713 (203)

Degradation of alpha-synuclein/SNCA mRNA by RNautophagy

Neurochemistry International
α-Synuclein is a neuronal protein and main component of Lewy bodies, the pathological hallmark of Lewy body diseases such as Parkinson's disease and dementia with Lewy bodies. While the accumulation of α-synuclein in neurons is implicated in the pathogenesis of these disorders, the mechanisms underlying α-synuclein mRNA degradation remain poorly ...
Chihana Kabuta, Fumihiko Hakuno, Naoyuki Kataoka, Shin-Ichiro Takahashi, Tomohiro Kabuta   +4 more
openaire   +2 more sources

Genetic variants and animal models in SNCA and Parkinson disease

Ageing Research Reviews, 2014
Parkinson disease (PD; MIM 168600) is the second most common progressive neurodegenerative disorder characterized by a variety of motor and non-motor features. To date, at least 20 loci and 15 disease-causing genes for parkinsonism have been identified. Among them, the α-synuclein (SNCA) gene was associated with PARK1/PARK4.
Hao, Deng, Lamei, Yuan
openaire   +2 more sources

SNCA polymorphisms, smoking, and sporadic Parkinson’s disease in Japanese

Parkinsonism & Related Disorders, 2012
Several case-control studies and genome-wide association studies have examined the relationships between single nucleotide polymorphisms (SNPs) in the SNCA gene and Parkinson's disease (PD), and have provided inconsistent results. We investigated the relationships between SNPs rs356229, rs356219, rs356220, rs7684318, and rs2736990 and the risk of ...
Yoshihiro, Miyake, Keiko, Tanaka, Wakaba, Fukushima, Chikako, Kiyohara, Satoshi, Sasaki, Yoshio, Tsuboi, Tatsuo, Yamada, Tomoko, Oeda, Hiroyuki, Shimada, Nobutoshi, Kawamura, Nobutaka, Sakae, Hidenao, Fukuyama, Yoshio, Hirota, Masaki, Nagai   +13 more
openaire   +2 more sources

Association of Alcohol Craving With α‐Synuclein (SNCA)

Alcoholism: Clinical and Experimental Research, 2007
Background: Studies have found that genomic variation in the gene SNCA, which encodes the protein α‐synuclein, may contribute to the variation in alcohol consumption in an inbred rat model of alcohol preference. Studies in humans have provided support for an association between SNCA and craving for alcohol.Methods: To examine the role of this gene in
Tatiana, Foroud, Leah Flury, Wetherill, Tiebing, Liang, Danielle M, Dick, Victor, Hesselbrock, John, Kramer, John, Nurnberger, Marc, Schuckit, Lucinda, Carr, Bernice, Porjesz, Xiaoling, Xuei, Howard J, Edenberg   +11 more
openaire   +2 more sources

Expanding the clinical phenotype of SNCA duplication carriers

Movement Disorders, 2009
AbstractSNCA duplication is a recognized cause of familial Parkinson's disease (PD). We aimed to explore the genetic and clinical variability in the disease manifestation. Molecular characterization was performed using real‐time PCR, SNP arrays, and haplotype analysis.
Kenya, Nishioka, Owen A, Ross, Kenji, Ishii, Jennifer M, Kachergus, Kiichi, Ishiwata, Mayumi, Kitagawa, Satoshi, Kono, Tomokazu, Obi, Koichi, Mizoguchi, Yuichi, Inoue, Hisamasa, Imai, Masashi, Takanashi, Yoshikuni, Mizuno, Matthew J, Farrer, Nobutaka, Hattori   +14 more
openaire   +2 more sources

α‐Synuclein antisense transcript SNCA‐AS1 regulates synapses‐ and aging‐related genes suggesting its implication in Parkinson's disease

Aging Cell, 2021
Cristina Cereda, Manuela TERESA Raimondi, Bianca Barzaghini   +2 more
exaly  

OLIGONUCLEOTIDES FOR SNCA MODULATION

2021
KHVOROVA ANASTASIA, FERGUSON CHANTAL, DAVIS SARAH, MONOPOLI KATHRYN   +3 more
openaire   +2 more sources

α-synuclein (SNCA)

Science-Business eXchange, 2014
openaire   +1 more source

SNCA

2011
openaire   +1 more source

SNCA

2008
openaire   +1 more source