Results 101 to 110 of about 3,236 (202)

Fed and fasted state gastro-intestinal in vitro lipolysis: In vitro in vivo relations of a conventional tablet, a SNEDDS and a solidified SNEDDS

European Journal of Pharmaceutical Sciences, 2014
The present study aims at evaluating the ability of a gastro-intestinal in vitro lipolysis model to predict the performance of two lipid formulations and a conventional tablet containing a poorly soluble drug, cinnarizine, in dogs, both in the fasted and fed state. A self-nano-emulsifying drug delivery system (SNEDDS) was either dosed in a hard gelatin
Christophersen, Philip Carsten B, Christiansen, Martin Lau, Holm, Rene, Kristensen, Jakob, Jacobsen, Jette, Abrahamsson, Bertil, Müllertz, Anette   +6 more
openaire   +3 more sources

Development of self-nanoemulsifying tablet (SNET) for bioavailability enhancement of sertraline

Brazilian Journal of Pharmaceutical Sciences, 2018
The purpose of the study was to combine the advantages of self-nanoemulsifying drug delivery systems and tablets as a conventional dosage form. Self-nanoemulsifying drug delivery system (SNEDDS) was prepared to enhance the solubility and thus oral ...
Mohammad Akhlaquer Rahman, Mohammad Mujahid   +1 more
doaj   +1 more source

THE DISSOLUTION AND DIFFUSION OF FUROSEMIDE ON SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) [PDF]

, 2017
Furosemide a diuretic exhibits low solubility in water and low bioavailability. The purpose of this study was to determine the effect SNEDDS formation to dissolution and diffusion of furosemide.
Martien, Ronny, Sugiyanto, Sugiyanto, wahyuningsih, iis -, Yuswanto, Ag.   +3 more
core   +2 more sources

Design and optimization of candesartan loaded self-nanoemulsifying drug delivery system for improving its dissolution rate and pharmacodynamic potential

Drug Delivery, 2020
During the last decades, much attention has been focused on SNEDDS approach to resolve concerns of BCS II class drugs with accentuation on upgrading the solubility and bioavailability. The present hypothesis confirms the theory that SNEDDS can reduce the
Ravinder Verma, Deepak Kaushik
doaj   +1 more source

Development of a new self-nanoemulsifying Narcissus tazetta L. oil delivery system and study of its anti-breast and anti-pancreas cancers activities in vitro

Food Hydrocolloids for Health
Administration of natural oil extracts suffers from low oral bioavailability and anti-proliferative activity. Self-nanoemulsifying drug delivery systems (SNEDDSs) are novel formulations to improvement of the efficacy of poorly water-soluble compounds. In
R. Nazari-Vanani, S.R. Rasouli Nasrabadi, S.A. Dastgheib, H. Heli   +3 more
doaj   +1 more source

Formulasi dan Aktivitas Antibakteri Gel Hand Sanitizer Ekstrak Air Daun Sirih Merah [PDF]

, 2016
Latar Belakang: Tuntutan zaman mengharuskan manusia untuk menjaga kesehatannya agar terhindar dari penyakit. Salah satunya dengan menggunakan pembersih tangan. Hand sanitizer hadir sebagai solusi dari permasalahan tersebut.
Milala, Alasen Sembiring, Umami, Tri Wahyu Riza, Wahjudi, Mariana   +2 more
core  

Formulasi Sediaan Nanoemulgel Ekstrak Kayu Secang (Caesalpinia sappan L.) Serta Uji Stabilitas Fisiknya [PDF]

, 2018
Sappan wood (Caesalpinia sappan L.) has potential antibacterial activity (P. acne), lipase inhibitors, and antioxidants which are indispensable for acne therapy.
, Erindyah RW., Ph.D., Apt, Rahman, Afzalur   +1 more
core  

Optimization of Naringenin Self-Nano Emulsifying Drug Delivery System (SNEDDS) Formula with D-optimal Mixture Design Method [PDF]

This study aimed to optimize and formulate the poorly water-soluble naringenin in the Self-Nano Emulsifying Drug Delivery System (SNEDDS) using D-optimal mixture design. D-optimal mixture design was used to optimize SNEDDS loading naringenin by selecting
Ikasari, Endang Diyah, Kuncahyo, Ilham, Yudanti, Gendis Purno   +2 more
core   +1 more source

Cell-penetrating self-nanoemulsifying drug delivery systems (SNEDDS) for oral gene delivery

Expert Opinion on Drug Delivery, 2016
Objective: The aim of study was to investigate whether cell-penetrating peptides could amplify cellular uptake of plasmid DNA (pDNA) loaded self-nanoemulsifying drug delivery systems (SNEDDS) by mucosal epithelial cells, thereby enhancing transfection efficiency.
Arshad, Mahmood, Felix, Prüfert, Nuri Ari, Efiana, Muhammad Imtiaz, Ashraf, Martin, Hermann, Shah, Hussain, Andreas, Bernkop-Schnürch   +6 more
openaire   +2 more sources

Pengaruh Perbedaan Perbandingan Kosnsentrasi Surfaktan dan Kosurfaktan 45:5, 40:10, 35:15 terhadap Stabilitas Fisik Self- Nanoemulsifying Drug Delivery Systems (Snedds) Atenolol dengan Fase Minyak Zaitun (Olive Oil) [PDF]

, 2020
ABSTRAK-Penelitian ini membahas tentang bagaimana cara meningkatkan kelarutan serta bioavailabilitas atenolol di dalam tubuh dengan memperkecil ukuran partikel atenolol menjadi bentuk nano (SNEDDS).
Aurellia Saputra, Endang Wahyu Fitriani
core   +1 more source