Animal cell cytokinesis: the role of dynamic changes in the plasma membrane proteome and lipidome [PDF]
, 2016 In animal cells, cytokinesis is characterised by the formation of the mitotic spindle that signals the assembly of an actomyosin ring between the spindle poles.
Gould, Gwyn W.
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ESCRT-III drives the final stages of CUPS maturation for unconventional protein secretion
eLife, 2016 The unconventional secretory pathway exports proteins that bypass the endoplasmic reticulum. In Saccharomyces cerevisiae, conditions that trigger Acb1 secretion via this pathway generate a Grh1 containing compartment composed of vesicles and tubules ...
Amy J Curwin +7 more
doaj +1 more source
Amino acid substitution equivalent to human chorea-acanthocytosis I2771R in yeast Vps13 protein affects its binding to phosphatidylinositol 3-phosphate [PDF]
, 2017 The rare human disorder chorea-acanthocytosis (ChAc) is caused by mutations in hVPS13A gene. The hVps13A protein interacts with actin and regulates the level of phosphatidylinositol 4-phosphate (PI4P) in the membranes of neuronal cells.
Ayscough, K.R. +6 more
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ESCRT function in cytokinesis : location, dynamics and regulation by mitotic kinases [PDF]
, 2014 Mammalian cytokinesis proceeds by constriction of an actomyosin ring and furrow ingression, resulting in the formation of the midbody bridge connecting two daughter cells. At the centre of the midbody resides the Flemming body, a dense proteinaceous ring
Bhutta, Musab S. +2 more
core +1 more source
Structure of cellular ESCRT-III spirals and their relationship to HIV budding [PDF]
, 2014 The ESCRT machinery along with the AAA+ ATPase Vps4 drive membrane scission for trafficking into multivesicular bodies in the endocytic pathway and for the topologically related processes of viral budding and cytokinesis, but how they accomplish this ...
Adell +70 more
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The vacuolar-sorting protein Snf7 is required for export of virulence determinants in members of the Cryptococcus neoformans complex. [PDF]
Scientific Reports, 2014 Fungal pathogenesis requires a number of extracellularly released virulence factors. Recent studies demonstrating that most fungal extracellular molecules lack secretory tags suggest that unconventional secretion mechanisms and fungal virulence are strictly connected.
Rodrigo M. da C. Godinho +8 more
openaire +2 more sources
Frontiers in Physiology, 2020 Whitefly Bemisia tabaci is a global invasive pest that causes substantial losses to agricultural crops worldwide either by direct feeding or vectoring numerous plant viruses.
Ramandeep Kaur +4 more
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BMC Biology, 2021 Background Comparing a parasitic lineage to its free-living relatives is a powerful way to understand how that evolutionary transition to parasitism occurred.
Shweta V. Pipaliya +8 more
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Journal of Cell Science, 2020 ABSTRACT The ESCRT-III protein complex executes reverse-topology membrane scission. The scission mechanism is unclear but is linked to remodeling of ESCRT-III complexes at the membrane surface. At endosomes, ESCRT-III mediates the budding of intralumenal vesicles (ILVs).
Dalton Buysse +4 more
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Mutational Analysis of Candida albicans SNF7 Reveals Genetically Separable Rim101 and ESCRT Functions and Demonstrates Divergence in bro1-Domain Protein Interactions [PDF]
Genetics, 2010 Abstract The opportunistic pathogen Candida albicans can grow over a wide pH range, which is associated with its ability to colonize and infect distinct host niches. C. albicans growth in neutral-alkaline environments requires proteolytic activation of the transcription factor Rim101.
Julie M, Wolf, Dana A, Davis
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