Results 71 to 80 of about 2,251 (162)

From Mitochondria to Immunity: The Emerging Roles of Mitochondria‐Derived Vesicles and Small Extracellular Vesicles in Cellular Communication and Disease

Journal of Extracellular Vesicles, Volume 14, Issue 11, November 2025.
ABSTRACT According to the endosymbiotic theory of mitochondrial origin, an α‐proteobacterium entered a prokaryotic cell and, through symbiosis, evolved into the mitochondria—the powerhouse of the cell. Like other bacteria, the α‐proteobacteria generate their own extracellular vesicles (EVs), a trait that was passed onto the mitochondria, enabling them ...
Rostyslav Horbay, Vasyl Syrvatka, Artem Bedzay, Mikaela van der Merwe, Dylan Burger, Shawn T. Beug   +5 more
wiley   +1 more source

Host ESCRT proteins are required for bromovirus RNA replication compartment assembly and function.

PLoS Pathogens, 2015
Positive-strand RNA viruses genome replication invariably is associated with vesicles or other rearranged cellular membranes. Brome mosaic virus (BMV) RNA replication occurs on perinuclear endoplasmic reticulum (ER) membranes in ~70 nm vesicular ...
Arturo Diaz, Jiantao Zhang, Abigail Ollwerther, Xiaofeng Wang, Paul Ahlquist   +4 more
doaj   +1 more source

Molecular Mechanisms of Extracellular Vesicle Biogenesis and Their Impact on the Design of Custom EVs

Advanced Healthcare Materials, Volume 14, Issue 23, September 8, 2025.
Extracellular vesicles (EVs) are pivotal mediators of intercellular communication and disease, yet the fundamental mechanisms controlling their biogenesis and cargo selection remain unclear. This limitation hinders their diagnostic utility and therapeutic development.
Luís Carvalho Ferraz, Paulo Pereira, João Vasco Ferreira   +2 more
wiley   +1 more source

Quantitative insertion-site sequencing (QIseq) for high throughput phenotyping of transposon mutants [PDF]

, 2016
Genetic screening using random transposon insertions has been a powerful tool for uncovering biology in prokaryotes, where whole-genome saturating screens have been performed in multiple organisms. In eukaryotes, such screens have proven more problematic,
Adams, John H., Bronner, Iraad F., Jiang, Rays H. Y., Otto, Thomas D., Quail, Michael A., Rayner, Julian C., Udenze, Kenneth, Wang, Chengqi, Zhang, Min   +8 more
core   +1 more source

The quest for the best target genes for RNAi‐mediated pest control

Insect Molecular Biology, Volume 34, Issue 4, Page 505-517, August 2025.
A major challenge for RNAi mediated pest control is the identification of the most effective RNAi target genes from the pool of ~37% of all genes that are essential. Effective RNAi target genes are predominantly highly conserved genes serving basic cellular functions such as protein degradation.
Doga Cedden, Gregor Bucher
wiley   +1 more source

Combinatory microarray and SuperSAGE analyses identify pairing-dependently transcribed genes in Schistosoma mansoni males, including Follistatin [PDF]

, 2013
Background: Schistosomiasis is a disease of world-wide importance and is caused by parasitic flatworms of the genus Schistosoma. These parasites exhibit a unique reproduction biology as the female’s sexual maturation depends on a constant pairing-contact
Beckmann, Svenja, Buro, Christin, Grevelding, Christoph G., Hahnel, Steffen, Kitajima, Joao P., Leutner, Silke, Oliveira, Katia C., Rotter, Bjoern, Verjovski-Almeida, Sergio, Winter, Peter   +9 more
core   +3 more sources

Environmental factors affecting RNAi efficacy: Temperature but not plant cultivar influences Colorado potato beetle's response to insecticidal dsRNA

Insect Molecular Biology, Volume 34, Issue 4, Page 581-592, August 2025.
Colorado potato beetle's RNA interference (RNAi) response was enhanced when insecticidal dsactin was consumed at high temperatures. The enhanced RNAi outcomes at high temperatures were not a function of dose or the expression of core RNAi genes. The potato cultivar consumed by Colorado potato beetle larvae did not affect RNAi outcomes, but larvae did ...
Mike Darrington, Jason Solocinski, Sophia K. Zhou, Melise C. Lecheta, Subba Reddy Palli, Yolanda H. Chen, Nicholas M. Teets   +6 more
wiley   +1 more source

Stability of ESCRT III Snf7 Polymer Influenced by: Bro1 and Vps2/Vps24 [PDF]

, 2016
The endosomal sorting complexes required for transport (ESCRT) are protein complexes that remodel cellular membranes. The ESCRT III membrane machinery has been implicated in regulating membrane bound receptor proteins through the multi-vesicular body ...
Coody, Troy K, III
core   +2 more sources

Identification and characterization of PlAlix, the Alix homologue from the Mediterranean sea urchin Paracentrotus lividus. [PDF]

, 2013
The sea urchin provides a relatively simple and tractable system for analyzing the early stages of embryo development. Here, we use the sea urchin species, Paracentrotus lividus, to investigate the role of Alix in key stages of embryogenesis, namely the ...
Anello, L, Bongiovanni, A, Di Bernardo, M., D’Azzo, A, MORICI, Giovanni, Romancino, D   +5 more
core   +1 more source

RNAi technology development for weed control: all smoke and no fire?

Pest Management Science, Volume 81, Issue 7, Page 3430-3436, July 2025.
Despite the potential of Spray‐Induced Gene Silencing in weed management several critical points such as molecular target, weed species of interest as well as delivery techniques need to be addressed. Abstract RNA interference (RNAi) technology, specifically Spray‐Induced Gene Silencing (SIGS), holds potential as an innovative approach for selective ...
Silvia Panozzo, Andrea Milani, Serena Bordignon, Laura Scarabel, Serena Varotto   +4 more
wiley   +1 more source