Results 81 to 90 of about 2,251 (162)
CellsMembers of the LGD/CC2D1 protein family contain repeats of the family-defining DM14 domains. Via this domain, they interact with members of the CHMP family, which are essential for the ESCRT machinery-mediated formation of intraluminal vesicles during ...
Thomas Breuer +3 more
doaj +1 more source
Detection and validation of single feature polymorphisms using RNA expression data from a rice genome array [PDF]
, 2009 BackgroundA large number of genetic variations have been identified in rice. Such variations must in many cases control phenotypic differences in abiotic stress tolerance and other traits.
Abdelbagi M Ismail +8 more
core +3 more sources
Nanomedicine Approaches for Autophagy Modulation in Cancer Therapy
Small Science, Volume 5, Issue 6, June 2025.Autophagy modulation holds promise for enhancing cancer treatment, yet clinical translation remains challenging. This review explores nanomedicine‐based strategies to improve autophagy‐targeting drugs, highlighting their synergy with chemotherapy, immunotherapy, phototherapy, and gene therapy. It also discusses nanoparticle design and clinical progress,
Sohaib Mahri +11 more
wiley +1 more source
A non-canonical ESCRT pathway, including histidine domain phosphotyrosine phosphatase (HD-PTP), is used for down-regulation of virally ubiquitinated MHC class I. [PDF]
, 2015 The Kaposi's sarcoma-associated herpes virus (KSHV) K3 viral gene product effectively down-regulates cell surface MHC class I. K3 is an E3 ubiquitin ligase that promotes Lys(63)-linked polyubiquitination of MHC class I, providing the signal for clathrin ...
Boname, Jessica M +7 more
core +2 more sources
RNA‐Based Biopesticides: Pioneering Precision Solutions for Sustainable Aquaculture in China
Animal Research and One Health, Volume 3, Issue 2, Page 165-176, May 2025.The Chinese dragon represents RNA biopesticides, which effectively counteract bacterial, viral, and parasitic threats, safeguarding aquatic life. This method is precise, focusing solely on harmful agents and sparing beneficial aquaculture species. Its innovative nature protects aquatic environments while reducing ecological footprint.
Yiran Huang +7 more
wiley +1 more source
Aspergillus nidulans ambient pH signaling does not require endocytosis
, 2015 9 p.-6 fig.-1 tab.Aspergillus nidulans (Pal) ambient pH signaling takes place in cortical structures containing components of the ESCRT pathway, which are hijacked by the alkaline pH-activated, ubiquitin-modified version of the arrestin-like protein PalF
Arst, HN +3 more
core +1 more source
A noncomplementation screen for quantitative trait alleles in Saccharomyces cerevisiae [PDF]
, 2012 Both linkage and linkage disequilibrium mapping provide well-defined approaches to mapping quantitative trait alleles. However, alleles of small effect are particularly difficult to refine to individual genes and causative mutations.
Fay, Justin C +4 more
core +2 more sources
Pest Management Science, Volume 81, Issue 2, Page 1026-1036, February 2025.RNAi based pest control is species‐specific and eco‐friendly but the optimal target genes have remained unclear. By a genome‐wide screen in the red flour beetle we identified the best target processes and showed transferability to other pests. The presented 34 superior target genes will guide applications in other species.
Benjamin Buer +11 more
wiley +1 more source
Characterisation of adipocyte-derived extracellular vesicles released pre- and post-adipogenesis [PDF]
, 2015 Extracellular vesicles (EVs) are submicron vesicles released from many cell types, including adipocytes. EVs are implicated in the pathogenesis of obesity-driven cardiovascular disease, although the characteristics of adipocyte-derived EVs are not well ...
Clayton, Aled +8 more
core +2 more sources
Advanced Science, Volume 11, Issue 35, September 18, 2024.Otilonium bromide (OTB) demonstrates efficacy against Candida albicans by targeting Sec31, thereby impeding vesicle transport and ergosterol localization, ultimately inducing cytotoxic autophagy. C. albicans exhibits susceptibility to OTB because it does not act as a substrate of drug pumps.
Cheng Zhen +7 more
wiley +1 more source