Results 11 to 20 of about 15,243 (207)

Systematic mapping of small nucleolar RNA interactions in human cells [PDF]

RNA Biology
Altered expression of box C/D small nucleolar RNAs (snoRNAs) is implicated in human diseases, including cancer. Box C/D snoRNAs canonically direct site-specific, 2’-O-methylation but the extent to which they participate in other functions remains unclear.
Hywel Dunn-Davies, Tatiana Dudnakova, Jean-Louis Langhendries, Nicholas Watkins, Denis L.J. Lafontaine, David Tollervey   +5 more
doaj   +2 more sources

snoRNAs Offer Novel Insight and Promising Perspectives for Lung Cancer Understanding and Management [PDF]

Cells, 2020
Small nucleolar RNAs (snoRNAs) are non-coding RNAs localized in the nucleolus, where they participate in the cleavage and chemical modification of ribosomal RNAs.
Nour-El-Houda Mourksi, Chloé Morin, Tanguy Fenouil, Jean-Jacques Diaz, Virginie Marcel   +4 more
doaj   +2 more sources

Annotation of snoRNA abundance across human tissues reveals complex snoRNA-host gene relationships [PDF]

Genome Biology, 2021
Background Small nucleolar RNAs (snoRNAs) are mid-size non-coding RNAs required for ribosomal RNA modification, implying a ubiquitous tissue distribution linked to ribosome synthesis.
Étienne Fafard-Couture, Danny Bergeron, Sonia Couture, Sherif Abou-Elela, Michelle S. Scott   +4 more
doaj   +4 more sources

RNase III cleavage sites spread across splice junctions enforce sequential snoRNA processing [PDF]

EMBO Reports
Small nucleolar RNAs (snoRNAs) are a class of eukaryotic non-coding RNA molecules whose precursor transcripts are capped and polyadenylated. However, these end modifications are detrimental to snoRNA function and must be removed, a process typically ...
Valérie Migeot, Yves Mary, Etienne Fafard-Couture, Pierre Lombard, François Bachand, Michelle S Scott, Carlo Yague-Sanz   +6 more
doaj   +2 more sources

CGSDA: inferring snoRNA-disease associations via ChebNetII and GatedGCN [PDF]

Frontiers in Genetics
IntroductionRecent biomedical studies have highlighted the pivotal role of non-coding RNAs (ncRNAs) in gene regulatory networks, where they influence gene expression, cellular function, and the onset and progression of various diseases.
Yongfu Zou, Yusong Lu, Shanghui Lu, Zhanliang Wei, Le Li, Shuilin Liao, Ting Zeng, Yi Zhang, Rui Miao   +8 more
doaj   +2 more sources

Mapping snoRNA-target RNA interactions in an RNA-binding protein-dependent manner with chimeric eCLIP [PDF]

Genome Biology
Background Small nucleolar RNAs (snoRNAs) are non-coding RNAs that function in ribosome and spliceosome biogenesis, primarily by guiding modifying enzymes to specific sites on ribosomal RNA (rRNA) and spliceosomal RNA (snRNA).
Zhuoyi Song, Bongmin Bae, Simon Schnabl, Fei Yuan, Thareendra De Zoysa, Maureen V. Akinyi, Charlotte A. Le Roux, Karine Choquet, Amanda J. Whipple, Eric L. Van Nostrand   +9 more
doaj   +2 more sources

Genome-wide analysis of chicken snoRNAs provides unique implications for the evolution of vertebrate snoRNAs [PDF]

BMC Genomics, 2009
Background Small nucleolar RNAs (snoRNAs) represent one of the largest groups of functionally diverse trans-acting non-protein-coding (npc) RNAs currently known in eukaryotic cells.
Guan Dao-Gang, Zhou Hui, Yang Jian-Hua, Shao Peng, Qu Liang-Hu   +4 more
doaj   +3 more sources

Accurate identification of snoRNA targets using variational graph autoencoder to advance the redevelopment of traditional medicines [PDF]

Frontiers in Pharmacology
Existing studies indicate that dysregulation or abnormal expression of small nucleolar RNA (snoRNA) is closely associated with various diseases, including lung cancer.
Zhina Wang, Zhina Wang, Yangyuan Chen, Hongming Ma, Hongming Ma, Hong Gao, Hong Gao, Yangbin Zhu, Hongwu Wang, Nan Zhang, Nan Zhang   +10 more
doaj   +2 more sources

Small nucleolar RNA SNORD13H suppresses tumor progression via FBL-dependent 2′-O-methylation in hepatocellular carcinoma [PDF]

Frontiers in Genetics
IntroductionSmall nucleolar RNA (snoRNA) mediates RNA modifications, including 2′-O-methylation (Nm) and pseudouridine (Ψ), which has been proven to impact tumor progression.
Minglu Zhang, Minglu Zhang, Minglu Zhang, Minglu Zhang, Jianbo He, Jianbo He, Jianbo He, Jianbo He, Rao Fu, Rao Fu, Rao Fu, Rao Fu, Guojian Bao, Guojian Bao, Guojian Bao, Yijun Lu, Yijun Lu, Yijun Lu, Zechuan Zhang, Zechuan Zhang, Zechuan Zhang, Jiawu Yan, Jiawu Yan, Jiawu Yan, Jialu Ding, Jialu Ding, Jialu Ding, Fei Yang, Fei Yang, Fei Yang, Fei Yang, Beicheng Sun, Beicheng Sun, Beicheng Sun, Beicheng Sun   +34 more
doaj   +2 more sources

GL4SDA: Predicting snoRNA-disease associations using GNNs and LLM embeddings [PDF]

Computational and Structural Biotechnology Journal
Small nucleolar RNAs (snoRNAs) play essential roles in various cellular processes, and their associations with diseases are increasingly recognized.
Massimo La Rosa, Antonino Fiannaca, Isabella Mendolia, Laura La Paglia, Alfonso Urso   +4 more
doaj   +2 more sources