Results 41 to 50 of about 15,243 (207)

Generation of a mouse model with down-regulated U50 snoRNA (SNORD50) expression and its organ-specific phenotypic modulation. [PDF]

PLoS ONE, 2013
Box C/D-type small nucleolar RNAs (snoRNAs) are functional RNAs responsible for mediating 2'-O-ribose methylation of ribosomal RNAs (rRNAs) within the nucleolus.
Yuuichi Soeno, Kazuya Fujita, Tomoo Kudo, Masataka Asagiri, Shigeru Kakuta, Yuji Taya, Yoshihito Shimazu, Kaori Sato, Ritsuko Tanaka-Fujita, Sachiko Kubo, Yoichiro Iwakura, Yoshikazu Nakamura, Shigeo Mori, Takaaki Aoba   +13 more
doaj   +1 more source

Expression of MicroRNAs Is Dysregulated by HIV While Mycobacterium tuberculosis Drives Alterations of Small Nucleolar RNAs in HIV Positive Adults With Active Tuberculosis

Frontiers in Microbiology, 2022
HIV infection affects the course of tuberculosis (TB), and HIV and Mycobacterium tuberculosis (Mtb) synergize in disease progression through complex immunological interplay.
Oskar Olsson, Oskar Olsson, Fregenet Tesfaye, Fregenet Tesfaye, Rolf Søkilde, Jolanta Mazurek, Markos Abebe, Habtamu Yeba, Abraham Aseffa, Sten Skogmar, Sten Skogmar, Taye Tolera Balcha, Carlos Rovira, Per Björkman, Per Björkman, Marianne Jansson   +15 more
doaj   +1 more source

SnoRNA signatures in cartilage ageing and osteoarthritis [PDF]

Scientific Reports, 2020
Abstract Osteoarthritis presents as a change in the chondrocyte phenotype and an imbalance between anabolic and catabolic processes. Age affects its onset and progression. Small nucleolar RNAs (SnoRNAs) direct chemical modification of RNA substrates to fine-tune spliceosomal and rRNA function, accommodating changing requirements for ...
Peffers, Mandy J, Chabronova, Alzbeta, Balaskas, Panagiotis, Fang, Yongxiang, Dyer, Philip, Cremers, Andy, Emans, Pieter, Feczko, Peter, Caron, Marjolein, Welting, Tim JM   +9 more
openaire   +4 more sources

Stable lariats bearing a snoRNA (slb-snoRNA) in eukaryotic cells: A level of regulation for guide RNAs [PDF]

Proceedings of the National Academy of Sciences, 2021
Significance Small nucleolar (sno)RNAs generally guide ribosomal RNA and small nuclear RNA modifications, essential events for ribosome and spliceosome biogenesis and function. Most are processed in the nucleus from lariat intronic RNAs, which are unstable byproducts of splicing.
Talross, Gaëlle J. S., Deryusheva, Svetlana, Gall, Joseph G.   +2 more
openaire   +2 more sources

Long Noncoding RNAs with snoRNA Ends [PDF]

Molecular Cell, 2012
We describe the discovery of sno-lncRNAs, a class of nuclear-enriched intron-derived long noncoding RNAs (lncRNAs) that are processed on both ends by the snoRNA machinery. During exonucleolytic trimming, the sequences between the snoRNAs are not degraded, leading to the accumulation of lncRNAs flanked by snoRNA sequences but lacking 5' caps and 3' poly(
Yin, Qing-Fei, Yang, Li, Zhang, Yang, Xiang, Jian-Feng, Wu, Yue-Wei, Carmichael, Gordon G., Chen, Ling-Ling   +6 more
openaire   +2 more sources

Comparative analysis of eukaryotic U3 snoRNA [PDF]

RNA Biology, 2009
The U3 snoRNA is an exceptional box C/D snoRNA, which is involved in pre-rRNA processing without directing chemical modifications. We report here on a comprehensive computational survey resulting in U3 sequences for more than 90 additional eukaryotes. This extended data basis is used to improve the secondary structure models. The detailed investigation
Marz, Manja, Stadler, Peter F.
openaire   +3 more sources

Mapping targets for small nucleolar RNAs in yeast [version 2; referees: 5 approved]

Wellcome Open Research, 2018
Background: Recent analyses implicate changes in the expression of the box C/D class of small nucleolar RNAs (snoRNAs) in several human diseases. Methods: Here we report the identification of potential novel RNA targets for box C/D snoRNAs in budding ...
Tatiana Dudnakova, Hywel Dunn-Davies, Rosie Peters, David Tollervey   +3 more
doaj   +1 more source

A Human snoRNA with MicroRNA-Like Functions [PDF]

Molecular Cell, 2008
Small noncoding RNAs function in concert with Argonaute (Ago) proteins to regulate gene expression at the level of transcription, mRNA stability, or translation. Ago proteins bind small RNAs and form the core of silencing complexes. Here, we report the analysis of small RNAs associated with human Ago1 and Ago2 revealed by immunoprecipitation and deep ...
Ender, Christine, Krek, Azra, Friedlaender, Marc R., Beitzinger, Michaela, Weinmann, Lasse, Chen, Wei, Pfeffer, Sebastien, Rajewsky, Nikolaus, Meister, Gunter   +8 more
openaire   +7 more sources

Mapping targets for small nucleolar RNAs in yeast [version 1; referees: 3 approved]

Wellcome Open Research, 2018
Background: Recent analyses implicate changes in the expression of the box C/D class of small nucleolar RNAs (snoRNAs) in several human diseases. Methods: Here we report the identification of potential novel RNA targets for box C/D snoRNAs in budding ...
Tatiana Dudnakova, Hywel Dunn-Davies, Rosie Peters, David Tollervey   +3 more
doaj   +1 more source

Small but Mighty—The Emerging Role of snoRNAs in Hematological Malignancies

Non-Coding RNA, 2021
Over recent years, the long known class of small nucleolar RNAs (snoRNAs) have gained interest among the scientific community, especially in the clinical context.
Jaime Calvo Sánchez, Marcel Köhn
doaj   +1 more source