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Selection of a Minimal Number of Significant Porcine SNPs by an Information Gain and Genetic Algorithm Hybrid Model [PDF]
Malaysian Journal of Computer Science, SI2, 79--95 (2019), 2019 A panel of large number of common Single Nucleotide Polymorphisms (SNPs) distributed across an entire porcine genome has been widely used to represent genetic variability of pig. With the advent of SNP-array technology, a genome-wide genetic profile of a specimen can be easily observed.
arxiv +1 more source
Investigations into the molecular effects of single nucleotide polymorphism [PDF]
, 2000 Objectives: DNA sequences are very rich in short repeats and their pattern can be altered by point mutations. We wanted to investigate the effect of single nucleotide polymorphism (SNP) on the pattern of short DNA repeats and its biological consequences.
Lohrer, Horst D., Tangen, Uwe
core +1 more source
BioTechniquesGenomic duplications are important sources of structural change and gene innovation. In humans, the most recent and highly identical sequences (>90% homology, >1 kb long) are known as segmental duplications (SDs). Single-nucleotide variants or single-nucleotide polymorphisms within SDs have not been systematically assessed due to limitations around ...
Shapour Jalilzadeh +3 more
openaire +3 more sources
Estimating Effects and Making Predictions from Genome-Wide Marker Data [PDF]
, 2009 In genome-wide association studies (GWAS), hundreds of thousands of genetic markers (SNPs) are tested for association with a trait or phenotype. Reported effects tend to be larger in magnitude than the true effects of these markers, the so-called ...
Goddard, Michael E. +3 more
core +1 more source
High Prevalence of Clostridioides difficile Ribotype 176 in the University Hospital in Kosice
Pathogens, 2023 Dysbiosis of the gut microbiota, caused by antibiotics, plays a key role in the establishment of Clostridioides difficile CD). Toxin-producing strains are involved in the pathogenesis of Clostridioides difficile infection (CDI), one of the most common ...
Katarina Curova +9 more
doaj +1 more source
Nature Reviews Microbiology, 2011 This month's Genome Watch highlights new perspectives on polygenic adaptation and its consequences for fitness in microbial populations.
openaire +3 more sources
Testing SNPs and sets of SNPs for importance in association studies [PDF]
Biostatistics, 2010 A major goal of genetic association studies concerned with single nucleotide polymorphisms (SNPs) is the detection of SNPs exhibiting an impact on the risk of developing a disease. Typically, this problem is approached by testing each of the SNPs individually.
Ingo Ruczinski +2 more
openaire +3 more sources
Joint analysis of SNP and gene expression data in genetic association studies of complex diseases [PDF]
Annals of Applied Statistics 2014, Vol. 8, No. 1, 352-376, 2014 Genetic association studies have been a popular approach for assessing the association between common Single Nucleotide Polymorphisms (SNPs) and complex diseases. However, other genomic data involved in the mechanism from SNPs to disease, for example, gene expressions, are usually neglected in these association studies.
arxiv +1 more source
Forensic SNP genotyping using nanopore MinION sequencing [PDF]
, 2017 One of the latest developments in next generation sequencing is the Oxford Nanopore Technologies' (ONT) MinION nanopore sequencer. We studied the applicability of this system to perform forensic genotyping of the forensic female DNA standard 9947 A using
Cornelis, Senne +4 more
core +2 more sources
Genome-wide SNP typing of ancient DNA: Determination of hair and eye color of Bronze Age humans from their skeletal remains. [PDF]
, 2020 Objective A genome-wide high-throughput single nucleotide polymorphism (SNP) typing method was tested with respect of the applicability to ancient and degraded DNA. The results were compared to mini-sequencing data achieved through single base extension (
Dörk, T. +5 more
core +2 more sources