Results 51 to 60 of about 23,427,651 (311)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The complete linkage disequilibrium test: a test that points to causative mutations underlying quantitative traits

Genetics Selection Evolution, 2011
Background Genetically, SNP that are in complete linkage disequilibrium with the causative SNP cannot be distinguished from the causative SNP. The Complete Linkage Disequilibrium (CLD) test presented here tests whether a SNP is in complete LD with the ...
Uleberg Eivind, Meuwissen Theo HE
doaj   +1 more source

SNP-SNP interaction models identified by the GMDR method with adjustment for age, gender, and education.

, 2017
SNP-SNP interaction models identified by the GMDR method with adjustment for age, gender, and education.
Chung-Feng Kao (104445), Po-Hsiu Kuo (104448), Yu-Li Liu (175348), Shih-Jen Tsai (160992), Albert C. Yang (222158), Eugene Lin (759907), Cheng-Hung Yang (3772732)   +6 more
core   +1 more source

Genome wide SNP discovery, analysis and evaluation in mallard (Anas platyrhynchos) [PDF]

, 2011
Background Next generation sequencing technologies allow to obtain at low cost the genomic sequence information that currently lacks for most economically and ecologically important organisms. For the mallard duck genomic data is limited. The mallard is,
Kerstens Hindrik HD, Prins, Herbert HT, Robert HS Kraus, van Hooft, Pim, Kraus, R.H.S., Prins, Herbert H. T., Prins, H.H.T., Poel, J., Van Hooft Pim, Hooft, Pim Van, Li Ning, Jan J Van Der Poel, Johan Elmberg, Huang Yinhua, Prins Herbert HT, Elmberg, Johan, Vignal Alain, Martien AM Groenen, Crooijmans, Richard P. M. A., Elmberg Johan, Groenen, M.A.M., van Hooft, Pim,, Van Der Poel Jan J, Huang, Y., Kraus, Robert Hs, Pim Van Hooft, Vignal, Alain, Crooijmans, R.P.M.A., Yinhua Huang, Groenen, Martien A. M., Vignal, Alain,, Li, N., Crooijmans, R., Kerstens, H., Crooijmans, Richard P. M. A.,, Herbert HT Prins, Elmberg, J., Groenen, M., Kerstens, Hindrik HD, Elmberg, Johan,, Kraus, Robert, Groenen, Martien AM, Prins, Herbert H. T.,, Kraus Robert HS, Prins, H., Huang, Yinhua,, Groenen Martien AM, Poel, J.J., van der, Kersten, H.H.D., van der Poel, Jan J., Li, Ning, Kraus, Robert H. S.,, Kraus, Robert H. S., Huang, Yinhua, Hooft, W.F., van, Crooijmans, Richard PMA, Kerstens, Hindrik H. D.,, Kerstens, Hindrik H. D., Li, Ning,, Hooft, P., Hindrik HD Kerstens, Richard PMA Crooijmans, Vignal, A., Alain Vignal, Kraus, R., Groenen, Martien A. M.,, Ning Li, Crooijmans Richard PMA, van der Poel, Jan J.,   +68 more
core   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

SNPs ANALYSIS AS A TOOL IN MOLECULAR GENETICS DIAGNOSTICS

Majalah Kedokteran Andalas, 2015
AbstrakSingle Nucleotide Polymorphism (SNP) merupakan variasi genetik yang ditemukan pada lebih dari 1% populasi. Haplotipe, yang merupakan sekelompok SNP atau alel dalam satu kromosom, dapat di turunkan ke generasi selanjutnya dan dapat digunakan untuk ...
Dewi Rusnita
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

SNP-bis

, 2012
SNP ...
Scotti-Saintagne, Caroline, Audigeos, Delphine, Caroline Scotti-Saintagne (202715), Louise Brousseau (710194), Ivan Scotti (151281), Brousseau, Louise, Delphine Audigeos (3292611), Scotti, Ivan, Stéphane Traissac (3292614), Traissac, Stéphane   +9 more
core   +1 more source

Simultaneous Analysis of All SNPs in Genome-Wide and Re-Sequencing Association Studies [PDF]

, 2008
Testing one SNP at a time does not fully realise the potential of genome-wide association studies to identify multiple causal variants, which is a plausible scenario for many complex diseases.
Maria De Iorio, John C Whittaker, Balding, DJ, De Iorio Maria, Clive J. Hoggart, Hoggart, Clive J, Balding, David J, David J Balding, Clive J Hoggart, Whittaker, John C, Balding David J., De Iorio, Maria, John C. Whittaker, Whittaker John C., De Iorio, M, Whittaker, JC, Hoggart Clive J., Hoggart, CJ, David J. Balding   +18 more
core   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source